Email this article Cytokines in primary biliary cirrhosis (diagnostic and prognostic implications)
- Authors: Golovanova EV1, Ilchenko LY.1, Tsaregorodtseva ТM1, Serova TI1, Gudkova RB1
-
Affiliations:
- Issue: Vol 79, No 2 (2004)
- Pages: 8-11
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29737
- ID: 29737
Cite item
Full Text
Abstract
Aim. To study concentrations of serum pro- and anti-inflammatory cytokines (CK), CK correlations with clinicobiochemical activity, diagnostic and prognostic implications in primary biliary cirrhosis (PBC).
Material and methods. Enzyme immunoassay has been used to study content of IL-1B, IL-4, IL-6, IL-8, TNF-a, INF-y in peripheral blood of 96 women aged 26 to 82 years (mean age 56.2 ± 12.6 years) with PBC (kits "Protein Contour", "Cytokine", St-Petersburg). The control group consisted of 20 healthy women matched by age.
Results. PBC is associated with changes in serum CK content correlating with the disease activity and stage. Elevated levels of proinflammatory IL-6, TNF-a, INF-y and anti-inflammatory IL-4. Conclusion. Definition of the cytokine spectrum in PBC has made a prognostic significance as it allows judging about the disease activity, stage and prognosis.
Material and methods. Enzyme immunoassay has been used to study content of IL-1B, IL-4, IL-6, IL-8, TNF-a, INF-y in peripheral blood of 96 women aged 26 to 82 years (mean age 56.2 ± 12.6 years) with PBC (kits "Protein Contour", "Cytokine", St-Petersburg). The control group consisted of 20 healthy women matched by age.
Results. PBC is associated with changes in serum CK content correlating with the disease activity and stage. Elevated levels of proinflammatory IL-6, TNF-a, INF-y and anti-inflammatory IL-4. Conclusion. Definition of the cytokine spectrum in PBC has made a prognostic significance as it allows judging about the disease activity, stage and prognosis.
Keywords
References
- Кашкин К. П. Цитокины иммунной системы: основные свойства и иммунобиологическая активность. // Клин. лаб. диагн. - 1998; 11: 21-32.
- Luster A. D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. - 1998; 338 (7): 436-445.
- Аруин Л. И. Апоптоз при патологических процессах в органах пищеварения. Клин мед. - 2000; 1: 5-10.
- Ивашкин В. Т., Буеверов А. О. Аутоиммунные заболевания печени в практике клинициста. М.: М-Вести; 2001.
- Masumoto Т., Ninomiya Т., Akbar S. M. F. et al. Determination of the interleukin-2 receptor beta chain by peripheras blood mononuclear cells in patients with primary biliary cirrhosis. Hepatol. Res. 1997; 8 (3): 207-214.
- Mohamed-Ali V., Bultner K., Clarke D. et al. Beta-adrenergic regulation of proinflammatory cytokines in humans. Int. Obes. Relat. Metab. Disord. 2000; 24 (suppl. 2): 154-155.
- Nagano Т., Yamamoto K., Matsumoto S. et al. Cytokine profile in the liver of primary biliary cirrhosis. J. Clin. Immunol. 1999; 19 (6): 422-427.
- Yazmaci E., Kara I., Goral V. et al. Serum levels of interleukin-ip, interleukin-2 receptor, interleukin-6 and tumor necrosis factor-a levels in patient with chronic liver disease. // J. of Hepatol. Abstracts of the 36"' Annual Meeting of the European Association for the Study of the Liver. 2001; 34 (suppl. 1) P/C09/16.
- Neutnan M., Angulo P., Malkiewicz I. et al. Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis. J. Gastroenterol. Hepatol. 2002; 17 (2): 196-202.
- Itoh S., Matsuzaki Y., Kimura T. et al. Cytokine profile of liver-infiltrating CD4+ T-cells separated from murine primary biliary cirrhosis-like hepatic lesions induced by graft-versushost reaction. J. Gastroenterol. Hepatol. 2000; 15 (4): 443- 451.
- Jones D. E., Palmer J. M., Bennett K. et al. Investigation of a mechanism for accelerated breakdown of immune tolerance to the primary biliary cirrhosis-associated autoantigen, pyruvate dehydrogenase complex. Lab. Invest. 2002; 82 (2): 211-219.
- Shiina M., Kobayashl K., Mano Y. et al. Up-regulation of CDlla (LFA-1) expression on peripheral CD4+ T-cells in primary biliary cirrhosis. Dig. Dis. Sci. 2002; 47 (6): 1209-1215.
- Лейшнер У. Практическое руководство по заболеваниям желчных путей: Пер. с нем. М.: ГЭОТАР-МЕД.; 2001.
- Шерлок Ш., Дули Дж. Заболевания печени и желчных путей: Пер с англ. М.: ГЭОТАР Медицина; 1999.
- Голованова Е. В. Диагностическое и прогностическое значение антимитохондриальных антител и цитокинов при первичном билиарном циррозе: Автореф. дис. ... канд. мед. наук. М.; 2001.
Supplementary files
