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Cerebral perfusion in patients with arterial hypertension and chronic vascular pathology of the brain
- Authors: Geraskina LA1, Suslina ZA1, Fonyakin AV1, Sharypova ТN1
-
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- Issue: Vol 78, No 12 (2003)
- Pages: 32-35
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29701
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Abstract
Aim. To examine cerebral perfusion in patients with dyscirculatory encephalopathy and residual disorders of cerebral circulation in arterial hypertension.
Material and methods. Duplex scanning of extra- and intracranial arteries, computed tomography of
the head were performed in 26 hypertensive patients with chronic vascular pathology of the brain. Cerebral perfusion was studied by the evidence obtained at single-photon emission computed tomography.
Results. Impaired segmental perfusion of the brain, primarily of frontal and temporal location, was
detected in 88.5% patients. Occlusive lesions of extra- and intracranial arteries were accompanied by
significant deterioration of the perfusion while visualization of leukoaraosis was associated with high
perfusion in the anterior frontal compartments indirectly pointing to defects in autoregulation of cerebral circulation. It was found that different correlations exist between perfusion of various segments of
the brain and systemic arterial pressure. This is explained by functional and hemodynamic heterogenic^ of different brain regions.
Conclusion. Specific features of cerebral perfusion in patients with chronic forms of vascular brain pathology should be considered in planning antihypertensive therapy because of the risk of focal hypoxia
and even ischemia in an inadequate fall of arterial pressure.
Material and methods. Duplex scanning of extra- and intracranial arteries, computed tomography of
the head were performed in 26 hypertensive patients with chronic vascular pathology of the brain. Cerebral perfusion was studied by the evidence obtained at single-photon emission computed tomography.
Results. Impaired segmental perfusion of the brain, primarily of frontal and temporal location, was
detected in 88.5% patients. Occlusive lesions of extra- and intracranial arteries were accompanied by
significant deterioration of the perfusion while visualization of leukoaraosis was associated with high
perfusion in the anterior frontal compartments indirectly pointing to defects in autoregulation of cerebral circulation. It was found that different correlations exist between perfusion of various segments of
the brain and systemic arterial pressure. This is explained by functional and hemodynamic heterogenic^ of different brain regions.
Conclusion. Specific features of cerebral perfusion in patients with chronic forms of vascular brain pathology should be considered in planning antihypertensive therapy because of the risk of focal hypoxia
and even ischemia in an inadequate fall of arterial pressure.
References
- Верещагин Н. В., Моргунов В. А., Гулевская Т. С. Патология головного мозга при атеросклерозе и артериальной гипертонии. М.: Медицина; 1997.
- Strandgaard S., Paulson О. В. Cerebrovascular damage in hypertention. J. Cardiovasc. Risk 1995; 2 (1): 34-39.
- Fayard P. В., Brass M. L. Single photon emission computed tomography in cerebrovascular disease. Stroke 1991; 22: 950-954.
- Podreka I., Baumgartner C, Suess E. et al. Quantification of regional cerebral blood flow with IMP-SPECT. ibid. 1989; 20: 183-191.
- Podreka I., Suess E., Goldenberg G. et al. Initial experience with technetium-99m HM-PAO brain SPECT. J. Nucl. Med. 1987; 28: 1657-1666.
- Мартынов А. И., Николаева Н. В., Калантаров К. Д., Верткий А. Л. Оценка влияния вазоактивных препаратов на церебральную гемодинамику. Клин, вести. 1996; Янв. - март: 18-20.
- Rodriguez G., Arvigo ¥., Marenco S. et al. Regional cerebral blood flow in essential hypertention: data evaluation by mapping system. Stroke 1987; 18: 13-20.
- Nobili F., Rodriguez G., Marenco S. et al. Regional cerebral blood flow in chronic hypertension (a correlative study). Ibid. 1993; 24: 1148-1153.
- Михеев В. Э., Самойленко Л. Е., Толпынина С. Н. и др. ОЭКТ головного мозга с "Тс-НМРАО" у пациентов с гипертонической болезнью. В кн.: Тезисы докладов Международной конф. "Современные проблемы ядерной медицины и радиофармацевтики", 11 Съезда Российского о-ва ядерной медицины. Обнинск; 2000. 23.
- Fujii К., Sadoshima S., Okdda Y. et al. Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits. Stroke 1990; 21: 283-290.
- Ганнушкина И. В., Лебедева Н. В. Гипертоническая энцефалопатия. М.: Медицина; 1987.
- Kobayashi S., Okada К., Yamashita К. Incidence of silent lacunar lesion in normal adults and its relation to cerebral blood flow and risk factors. Stroke 1991; 22: 1379-1383.
- Oishi M., Mochizuki Y., Takasu T. Blood flow differences between leucoaraiosis with and without lacunar infarction. Can.J. Neurol. Sci. 1998; 25 (1): 70-75.
