The test for nitric oxide metabolites in the exhaled aircondensate as a method of assessing NO-reactivity of theairways in patients with bronchial asthma


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Abstract

Aim. To estimate airways NO-reactivity in response to their stimulation with fenoterol in different
clinical forms of bronchial asthma (BA).
Material and methods. The study included 73 patients with BA: mild disease was in 21, moderate in 24 and severe - in 28 patients. Severe BA patients were divided into two subgroups: with a stable
course (n - 15) and unstable course (n = 13). NO-producing function of the airways was estimated
by concentration of stable NO-metabolites (mNO)(N02, N03) in exhaled air condensate.
Results. Spontaneous NO-producing activity of the airways increases and reaches maximum in severe
unstable asthma. Fenoterol-stimulated NO-production was minimal in mild BA while the most significant augmentation of mNO was observed in unstable BA. Basal level of mNO and velocity parameters
of external respiration function correlated.
Conclusion. Estimation of NO-reactivity of the airways in the test with fenoterol with calculation of
the index of airways NO-reactivity provides additional information about respiratory system condition
in BA patients which may be used in clinical pulmonology.

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