Syndrome ofnon-thyroid pathology in patients with cardiovascular diseases (review)


  1. De Groot L. J. Dangerous dogmas in medicine: The nonthyroidal illness syndrome. J. Clin. Endocrinol. Metab. 1999; 84 (1): 151-164.
  2. Mclver В., Gorman С A. Euthyroid sick syndrome: an overview. Thyroid 1997; 7: 125-132.
  3. Hennemann G., Docter R., Krenning E. P. Causes and effects of the low T3 syndrome during caloric deprivation and non-thyroidal illness: an overview. Acta Med. Kaust. 1988; 15: 42-45.
  4. Chow С. С, Мак Т. W., Chan С, H, Соскгат С. S. Euthyroid sick syndrome in tuberculosis before and after treatment. Ann. Clin. Biochem. 1995; 32: 385-391.
  5. Cherem H. J., Nellen H. H., Barabejski F. G. et al. Thyroid function and abdominal surgery. A longitudinal study. Arch. Med. Res. 1992; 23: 143-147.
  6. Vardarli I., Schmidt R., Wdowinski J. M. et al. The hypothalamo-hypophyseal thyroid axis, plasma protein concentrations and the hypophyseogonadal axis in low T3 syndrome following acute myocardial infarction. Klin. Wschr. 1987; 65: 129-133.
  7. Eber В., Schumacher M., Langsteger W. et al. Changes in thyroid hormone parameters after acute myocardial infarction. Cardiology 1995; 86: 152-156.
  8. Holland F. W., Brown P. S., Weintraub B. D., Clark R. E. Cardiopulmonary bypass and thyroid function: a "euthyroid sick syndrome." Ann. Thorac. Surg. 1991; 52: 46-50.
  9. Vexiau P., Perez-Castiglioni P., Socle G. et al. The "euthyroid sick syndrome": incidence, risk factors and prognostic value soon after allogeneic bone marrow transplantation. Br. J. Haematol. 1993; 85: 778-782.
  10. Arem R., Wiener G. J., Kaplan S. G. et al. Reduced tissue thyroid hormone levels in fatal illness. Metabolism 1993; 42 (9): 1102-1108.
  11. Di Napoli M., Reda G., Zannoni G. et al. The euthyroid sick syndrome. Its incidence and clinical significance in an internal medicine department. Minerva Med. 1994; 85 (4): 161 - 165.
  12. Camacho P. M., Dwarkanathan A. A. Sick euthyroid syndrome. What to do when thyroid function tests are abnormal in critically ill patients. Postgrad. Med. 1999; 105 (4): 215-219.
  13. Chopra I. J., Hershman J. M., Pardridge W. M., Nicoloff J. T. Thyroid function in nonthyroidal illness. Ann. intern. Med. 1983; 98: 946-957.
  14. Umpierrez G. E. Euthyroid sick syndrome. South. Med. J. 2002; 95 (5): 506-513.
  15. Slag M. F., Morley J. E., Ebon M. K. et al. Hypothyroxinemia in critically ill patients as a predictor of high mortality. J. A. M. A. 1981; 245 (1): 43-45.
  16. Wartofsky L., Barman К D. Alterations in thyroid function in patients with systemic illnesses: the "euthyroid sick syndrome." Endocr. Rev. 1982; 3: 164-217.
  17. De Marinis L., Mancini A., Masala R. et al. Evaluation of pituitary-thyroid axis response to acute myocardial infarction. J. Endocrinol. Invest. 1985; 8: 507.
  18. Vaughan G. M., Mason A. D., McManus W. F., Pruitt B. A. Alterations of mental status and thyroid hormones after thermal injury. J. Clin. Endocrinol. Metab. 1985; 60: 1221.
  19. Maldonado L. S., Murata G. N.. Hershman J. M., BraunsteinG. D. Do thyroid function tests independently predict survival in the critically ill? Thyroid 1992; 2: 119.
  20. Becker K. L. Euthyroid sick syndrome. In: Becker K. L., ed. Principles and practice of endocrinology and metabolism. 2-nd ed. Philadelphia: Lippincott; 1995. 1786.
  21. Nicoloff J. Т., LoPresti J. Nonthyroidal illness. In: DeGroot L. J., ed. Endocrinology. Philadelphia; 1995; 665-673.
  22. Friberg L., Werner S., Eggertsen G., Ahnve S. Rapid down-regulation of thyroid hormones in acute myocardial infarction: is it cardioprotective in patients with angina? Arch. Intern. Med. 2002; 162(12): 1388-1394.
  23. Kimura Т., Kanda Т., Kotajlma N. et al. Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. Eur. J. Endocrinol. 2000; 143 (2): 179-184.
  24. Ohyama Т., Nakal A., Nagasaka A. et al. Change in serum thyroid hormone levels in patients with acute myocardial infarction. Nippon Naibunpi Gakkai Zasshi 1987; 63 (1): 19-25.
  25. Pavlou H. N., Kliridis P. A., Panagiotopoulos A. A. et al. Euthyroid sick syndrome in acute ischemic syndromes. Angiology 2002; 53 (6): 699-707.
  26. Friberg L., Drvota V., Bjelak A. H. et al. Association between increased levels of reverse triiodothyronine and mortality after acute myocardial infarction. Am. J. Med. 2001; 111 (9): 699- 703.
  27. Miguel Bayarri V., Borras Palle S., Murcia Llacer B. et al. Prevalence and prognosis significance of euthyroid sick syndrome in critical illness. Rev. Clin. Esp. 2001; 201 (10): 572- 574.
  28. Hamilton M. A., Stevenson L. W., Luu M., Walden J. A. Altered thyroid hormone metabolism in advanced heart failure. J.Am. Coll. Cardiol. 1990; 16 (1): 91-95.
  29. Shlmoyama N., Maeda Т., Inoue T. et al. Serum thyroid hormone levels correlate with cardiac function and ventricular tachyarrhythmia in patients with chronic heart failure. J. Car- diol. 1993; 23 (2): 205-213 .
  30. Opasich C, Pacini F., Ambrosino N. et al. Sick euthyroid syndrome in patients with moderate-tosevere chronic heart failure. Eur. Heart. J. 1996; 17 (12): 1860-1866 .
  31. Shanoudy H., Soliman А., Мое S. et al. Early manifestations of "sick euthyroid" syndrome in patients with compensated chronic heart failure. J. Card. Fail. 2001; 7 (2): 146-152.
  32. Savastano S., Cannavale V., Valentino R. et al. AlphaANP, AVP, and pituitary-thyroid axis in patients with congestive heart failure and acute respiratory failure. J. Endocrinol. In- vest. 1999; 22 (10): 766-771.
  33. Manowitz N. R., Mayor G. H., Klepper M. J., DeGroot L. J. Subclinical hypothyroidism and euthyroid sick syndrome in patients with moderate-to-severe congestive heart failure. Am.J. Ther. 1996 ; 3 (12): 797-801.
  34. Hamilton M. A., Stevenson L. W. Thyroid hormone abnormalities in heart failure: possibilities for therapy. Thyroid 1996; 6 (5): 527-529.
  35. Glinoer D. Comment on dangerous dogmas in Medicine. - The nonthyroidal illness syndrome. J. Clin. Endocrinol. Metab. 1999; 84 (6): 2262.
  36. Kobayashi K, Okada M., Ishiguro S. et al. Studies on nonthyroidal illness after heart surgery. Nippon Geka Gakkai Zasshi 1991; 92 (7): 852-861.
  37. Ho W. M., Wang Y. S., Tsou С. Т. et al. Thyroid function dur ing isoflurane anesthesia and valvular heart surgery. J. Cardiothorac. Anesth. 1989; 3 (5): 550-557.
  38. Thrush D. N., Austin D., Burdash N. Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? Chest 1995; 108 (6): 1541-1545.
  39. Novitzky D., Cooper D. K., Barton C. I. et al. Triiodothyronine as an inotropic agent after open heart surgery. J. Thorac. Cardiovasc.Surg. 1989; 98 (5, pt 2): 972-977.
  40. Novitzky D., Cooper D. K, Swanepoel A. Inotropic effect of triiodothyronine (T3) in low cardiac output following cardioplegic arrest and cardiopulmonary bypass: an initial experience in patients undergoing open heart surgery. Eur. J. Cardiothorac. Surg. 1989; 3 (2): 140-145.
  41. Klemperer J. D., Klein I., Gornez M. et al. Thyroid hormone treatment after coronary-artery bypass surgery. N. Engl. J. Med. 1995; 333 (23): 1522-1527.
  42. Bettendorf M., Schmidt K. G., Grulich-Henn J. et al. Triiodothyronine treatment in children after cardiac surgery: a doubleblind, randomised, placebo-controlled study. Lancet 2000; 356: 529-534.
  43. Bennett-Guerrero E., Jimenez J- L., White W. D. et al. Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass graft surgery. A randomized, double-blind placebo-controlled trial. J. A. M. A. 1996; 275: 687-692.
  44. Teiger E., Menasche P., Mansier P. et al. Triiodothyronine therapy in open-heart surgery: from hope to disappointment. Eur. Heart. J. 1993; 14: 629-633.
  45. Vavouranakis L, Sanoudos G, Manios A. et al. Triiodothyronine administration in coronary artery bypass surgery: effect on hemodynamics. J. Cardiovasc. Surg. 1994; 35: 383-389.
  46. Gomberg-Maitland M., Frishman W. H. Thyroid hormone and cardiovascular disease. Am. Heart. J. 1998; 135 (2): 187-196.
  47. Utiger R. D. Altered thyroid function in nonthyroidal illness and surgery - to treat or not to treat? Editorial. N. Engl. J. Med. 1995; 333 (23): 1562-1563 .
  48. Nademanee K, Singh B. N., Hendrickson J. A. et al. Pharma- cokinetic significance of serum reverse T3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapy. Circulation 1982; 66: 202-211.
  49. Rumolo R., Vitolo E., Tronci M. et al. Alterations in thyroid function induced by chronic administration of amiodarone. Drugs. Exp. Clin. Res. 1987; 13 (1): 29-35.
  50. Van den Berghe G., de Zegher F. Anterior pituitary function during critical illness and dopamine treatment. Crit. Care. Med.1996; 24: 1580-1590.
  51. Chopra I. J. Simultaneous measurement of free thyroxine and free 3,5,3'-triiodothyronine in undiluted serum by direct equilibrium dialysis/radioimmunoassay: evidence that free triiodothyronine and free thyroxine are normal in many patients with the low triiodothyronine syndrome. Thyroid 1998; 8: 249-257.
  52. Faglia G, Ferrari С, Beck-Peccoz Р- et al. Reduced plasma thyrotropin response to thyrotropin releasing hormone after dexamethasone administration in normal subjects. Horm. Metab. Res. 1973; 5: 289-292.
  53. Kaplan M. M., Utiger R. D. lodothyronine metabolism in liver and kidney homogenates from hyperthyroid and hypothyroid rats. Endocrinology 1978; 103: 156-161.
  54. Jaume J. C, Mendel С M., Frost P. H. et al. Extremely low doses of heparin release lipase activity into the plasma and can thereby cause artifactual elevations in the serum-free thyroxine concentration as measured by equilibrium dialysis. Thyroid 1996; 6: 79-83



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