Specific functional condition of the autonomic nervous system in patients with diabetes mellitus

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Aim. To evaluate prognostic significance of autonomic nervous system (ANS) dysfunction in patients
with diabetes mellitus (DM).
Material and methods. The examination covered 51 DM type 1 patients aged 18 to 43 years with DM
history from 6 months to 31 years. ANS function was assessed by spectral analysis of cardiac rhythm
with calculation of indices of rhythm "rigidity", centralization and activity of subcortical centers.
Results. DM progression and development of its late complications were accompanied with dissociation
of tonicity of the sympathetic and parasympathetic ANS components, augmentation of regulatory systems tension. Evidence was obtained for correlation of relative values of SW1 power with severity of
DM (r = 0.88) and its microvascular complications (r = 0.70). Decreased power of MW2(%) in the
tilt test predicts development of orthostatic hypotension.
Conclusion. Involvement in the regulation of the central contour of ANS management reflects adaptation failure and is prognostically significant.

About the authors

Т Е Chernyshova


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