Email this article Recurrence of gastropathies caused by administration of nonsteroid anti-inflammatory drugs
- Authors: Karateev AЕ1
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Affiliations:
- Issue: Vol 78, No 5 (2003)
- Pages: 74-78
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29398
- ID: 29398
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Abstract
Aim. To estimate frequency of ulcers and erosions associated with administration of nonsteroid antiinflammatory drugs (NSAID) in patients with rheumatic diseases.
Material and methods. The analysis of the clinic endoscopic data base allowed division of the patients into three groups: group 1 -207 patients examined with esophagogastroduodenoscopy (EGDS) which detected ulcers or multiple erosions of the stomach and/or duodenum in the course of treatment with NSAID; group 2 - 157patients with a few erosions of the stomach or duodenum; group 3 - 404 controls who had neither erosions nor ulcers in the course of NSAID treatment.
Results. Frequency of detection of ulcers and multiple erosions for groups 1, 2 and 3 was 40.1, 12.1 and 7.4%, respectively. Recurrences did not correlate with age, sex, dose of glucoorticosteroids, NSAID dose, cytostatics, preventive use of antiulcer drugs. Few gastric erosions were detected more frequently in patients of group 2 than group 3 (22.9 and 9.2%, respectively, p < 0.05). Conclusion. NSAID-induced ulcers in patients with rheumatic diseases are recurrent. Preventive intake of H2-blockers did not lower the risk of ulcer recurrence. Erosions tend to recurrence but their presence do not raise the risk of ulcer development.
Material and methods. The analysis of the clinic endoscopic data base allowed division of the patients into three groups: group 1 -207 patients examined with esophagogastroduodenoscopy (EGDS) which detected ulcers or multiple erosions of the stomach and/or duodenum in the course of treatment with NSAID; group 2 - 157patients with a few erosions of the stomach or duodenum; group 3 - 404 controls who had neither erosions nor ulcers in the course of NSAID treatment.
Results. Frequency of detection of ulcers and multiple erosions for groups 1, 2 and 3 was 40.1, 12.1 and 7.4%, respectively. Recurrences did not correlate with age, sex, dose of glucoorticosteroids, NSAID dose, cytostatics, preventive use of antiulcer drugs. Few gastric erosions were detected more frequently in patients of group 2 than group 3 (22.9 and 9.2%, respectively, p < 0.05). Conclusion. NSAID-induced ulcers in patients with rheumatic diseases are recurrent. Preventive intake of H2-blockers did not lower the risk of ulcer recurrence. Erosions tend to recurrence but their presence do not raise the risk of ulcer development.
References
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