Short- and long-term outcomes after implantation of coronary stent "EPHESOS" in patients with stable or unstable angina

Abstract

Aim. An open non-randomized trial was initiated to assess clinical and angiographic results of using the coronary stent "Ephesos" in 457patients with stable or unstable angina pectoris and native coronary affections.
Material and methods. 268 stents have been implanted in 231 patients with stable angina (SA) and 271 stents - in 226 patients with unstable angina (UA). 46% lesions were complicated. The length of stenosis was 12.9 ± 6.7 mm in the group SA and 14.1 ± 7.4 mm in the group UA, 30%? stenoses were long.
Results. Successful stenting was stated in 99%, without cases of acute thrombosis. Non-fatal myocardial infarction took place in hospital in 1.3% of SA patients and in 2.6% of UA patients. Incidence of cardiac complications (death, recurrent angina pectoris, myocardial infarction, restenosis, repeated revascularization) for 6-month follow-up was 15.6% in SA group and 18.1% in UA group. At angiographic control, the index of vascular diameter loss made up 0.22 ±0.2 in SA group and 0.3 ± 0.27 in UA group. Incidence of restenosis was 12 and 14%, respectively. 18-month follow-up found no differences in frequency of complications: 21.6 and 22.6%, in groups SA and UA, respectively. Conclusion. Implantation of the stent "Ephesos" is effective in prevention of thrombosis and restenosis in patients with stable or unstable angina pectoris at high risk of intervention.

References

  1. Bahr R. D., Leino E. V., Christenson R. Н. Prodromal unstable angina in acute myocardial infarction: prognostic value of short- and long-term outcome and predictor of infarct size. Am. Heart J. 2000; 140 (1): 126-133.
  2. Hills W. S. The continuing debate: conservative or interventional therapy for unstable coronary artery disease. Am. J. Cardiol. 1997; 80 (5A): 51E-54E.
  3. Smith S. C., Dove J. T, Jacobs A. K. et al. ACC/AHA Guidelines for percutaneous coronary intervention. (Revision of the 1993 PTCA guidelines). A report of the ACC/AHA task force on practice guidelines. J. Am. Coll. Cardiol. 2001; 37: 2239.
  4. Mark D. В., Nelson С. L., Califf R. M. et al. Continuing evolution of therapy for coronary artery disease: Initial results from the era of coronary angioplasty. Circulation 1994; 89: 2015- 2025.
  5. Steg P. G., Himbert D., Seknadju P. Revascularization of patients with unstable coronary artery disease: The case for early intervention. Am. J. Cardiol. 1997; 80 (5A): 45E-50E.
  6. Bertrand M. E., Simoons M. L., Fox K. A. A. et al. Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Eur. Heart J. 2000; 21: 1408-1432.
  7. Serruys P. W. van Hout В., Bonnier H. et al. Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (BENESTENT II). Lancet 1998; 352: 673-681.
  8. Pershukov I. V., Batyraliev T. A., Samko A. N. et al. Clinical and angiographic outcome after coronary arterial stenting with the Ephesos-stent. Int. J. Cardiovasc. Intervent. 2001; 4 (suppi. 1): 7.
  9. Батыралиев Т. А., Самко А. Н., Першуков И. В. и др. Клинические и ангиографические результаты применения стента EH PESOS у больных с атеросклерозом коронарных артерий. Кардиология 2002; 42 (2): 4-7.
  10. Jang G. D., Ribeiro P. A. The ideal characteristics of a coronary stent. Rev. Port. Cardiol. 1999; 18 (suppl. 1): 87-95.
  11. Rogers C., Edelman E. R. Endovascular stent design dictates experimental restenosis and thrombosis. Circulation 1995; 91: 2995-3001.
  12. Kornowski R., Hong M. K., Tio F. O. et al. In-stent restenosis: contributions of inflammatory response and arterial injury to neointimal hyperplasia. J. Am. Coll. Cardiol. 1998; 31: 224- 230.
  13. Hardhammar P. A., van Beusekom H. M. M., Emauelsson H. V. et al. Reduction in thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary arteries. Circulation 1996; 93: 423-430.
  14. Antoniucci D., Bartorelli A., Volenti R. et al. Clinical and angiographic outcome after coronary arterial stenting with the carbostent. Am. J. Cardiol. 2000; 85: 821-825.
  15. Eltchaninoff H., Pilliere R., Traisnel G. et al. Acute and sixmonth clinical outcome after helistent stent implantation in coronary arteries: Results of the French helistent multicenter registry. Cathet. Cardiovasc. Intervent. 2002; 56: 295-299.
  16. Boland J. L., Corbeij H. A. M., Van Der Giessen W. et al. Multicenter evaluation of the phosphorylcholinecoated biodivysio stent in short de novo coronary lesions: The SOPHOS study. Int. J. Cardiovasc. Intervent. 2000; 3: 215-225.
  17. Bilodeau L., Schreiber T, Hilton J. D. et al. The Wallstent in native coronary arteries (WIN) multicenter randomized trial: in-hospital acute results. J. Am. Coll. Cardiol. 1998; 31: 80A.
  18. Batyraliev Т. А., Samko A. N., Pershukov I. V. et al. Immediate and long-term effects of coronary stent BIODIAMOND implantation. Ter. Arkh. 2002; 74 (2): 57-60.

Copyright (c) 2003 Samko A.N., Pershukov I.V., Batyraliev Т.A., Niyazova-Karben Z.A., Calenici О., Karaus A., Guler N., Eryonucu В., Kadayifci S., Temamogullari A., Ozgul S., Akgul F., Levitsky I.V., Sozykin A.V., Besnili F., Arful F., Jamgyrchiev S.Т., Sercelik A., Sengul H., Daniyarov B.S., Demirbas O., Belenkov Y.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

© 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies