Role of some neurohumoral factors in the development of pulmonary hypertension in patients with interstitial Jung diseases
- Authors: Arkhipova DV1, Kornev BM1, Popova EN1, Kogan EA1, Osipenko VI1, Privalova EV1, Kobylensky AG1, Mescheryakova SA1, Efremov EE1
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- Issue: Vol 78, No 3 (2003)
- Pages: 44-49
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29343
- ID: 29343
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Abstract
Results. The highest mean pressure in the pulmonary artery (PmPA) was registered in IFA vs EAA and ILD-DDCT patients (p < 0.001). NO concentration in plasma was higher in ILD-DDCT than in control patients. In IFA and EAA the level of NO was like in controls. Concentration of NO in plasma oflDL patients correlated with high activity of the process. No correlation was found between ACE in plasma and PmPA, ACE levels were much higher in controls than in the ILD patients (p < 0.05). Histamine levels were higher in ILD patients than in controls being the highest in ILD-DDCT. Serotonin was insignificantly higher in ILD patients than in controls.
Conclusion. Damage to the endothelium of the pulmonary arteries and imbalance of neurohumoral factors may be considered as a mechanism of development and stabilization of PH in ILD patients.
About the authors
D V Arkhipova
B M Kornev
E N Popova
E A Kogan
V I Osipenko
E V Privalova
A G Kobylensky
S A Mescheryakova
E E Efremov
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