Email this article Changes in exocrine and endocrine secretion of the pancreas in the treatment of chronic pancreatitis of alcoholic etiology with somatostatin analogue
- Authors: Vinokurova LV1, Astafyeva OV1, Banifatov PV1
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Affiliations:
- Issue: Vol 78, No 2 (2003)
- Pages: 48-50
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29314
- ID: 29314
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Abstract
Aim. To study somatostatin (SS) content in patients with chronic pancreatitis (CP) and effects ofsandostatin (a synthetic analogue of SS) on endo- and exocrine pancreatic functions in CP patients. Material and methods. SS plasma levels were measured by radioimmunoassay in basal conditions in 32 CP patients. Sandostatin treatment was given to 20 patients with CP of alcohol etiology (twice a day subcutaneously for 5 days). In the course of the treatment the following indices were measured: serum trypsin, amilase, lipase, a2-macroglobulin, general antitryptic activity, blood immunoreactive insulin in basal conditions and after intravenous injection of glucose.
Results. SS levels in peripheral blood were elevated in patients with complicated alcoholic CP. Sandostatin in CP used for 5 days had no significant impact on insulin secretion, levels of pancreatic enzymes, inhibiting system of blood. 90% patients with alcoholic СР experienced relief of pain which may relate to suppression of stimulated secretion of gastrointestinal hormones as well as to a favourable action of sandostatin on stabilization of membranes of acinar cells.
Conclusion. Sandostatin administration in CP patients is justified and is especially recommended in the complicated course.
Results. SS levels in peripheral blood were elevated in patients with complicated alcoholic CP. Sandostatin in CP used for 5 days had no significant impact on insulin secretion, levels of pancreatic enzymes, inhibiting system of blood. 90% patients with alcoholic СР experienced relief of pain which may relate to suppression of stimulated secretion of gastrointestinal hormones as well as to a favourable action of sandostatin on stabilization of membranes of acinar cells.
Conclusion. Sandostatin administration in CP patients is justified and is especially recommended in the complicated course.
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References
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