Preparation of nanodiamond conjugates with scandium isotopes for use in nuclear medicine

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In this work, we studied the sorption of scandium, whose isotopes 44Sc and 47Sc are studied for diagnostics and therapy in nuclear medicine, by aggregates of commercial (TAN, STP) and oxidized ND nanodiamonds (ox-STP) from aqueous solutions. The sorption capacity of the studied NDs for scandium was determined; it was shown that 100 μg of NDs is sufficient for the sorption of 1 GBq of 47Sc, which is equivalent to the activity of isotopes used in therapy. It has been shown that the supposed mechanism for the binding of Sc(III) to ND aggregates is chemisorption, and the chemical composition of the ND surface affects the sorption efficiency to a greater extent than the forms of scandium in solution. The obtained data on Sc(III) sorption are compared with the sizes of ND aggregates; it is shown that sorption under experimental conditions does not depend on the size of the aggregates. Optimal carriers of the 47Sc isotope have been found for further studies of radiopharmaceuticals based on it – TAN and ox-STP.

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作者简介

A. Kazakov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

编辑信件的主要联系方式.
Email: adeptak92@mail.ru
俄罗斯联邦, Moscow

T. Ekatova

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
俄罗斯联邦, Moscow

S. Vinokurov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
俄罗斯联邦, Moscow

E. Khvorostinin

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
俄罗斯联邦, Moscow

I. Ushakov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
俄罗斯联邦, Tomsk

V. Zukau

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
俄罗斯联邦, Tomsk

E. Stasyuk

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
俄罗斯联邦, Tomsk

E. Nesterov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
俄罗斯联邦, Tomsk

V. Sadkin

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
俄罗斯联邦, Tomsk

A. Rogov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
俄罗斯联邦, Tomsk

B. Myasoedov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences

Email: adeptak92@mail.ru
俄罗斯联邦, Moscow; Moscow

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2. Fig. 1. Kinetics of Sc(III) sorption by TAN (a), STP (b) and ox-STP (c) aggregates (20 ng/ml Sc, 100 μg/ml NA).

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3. Fig. 2. Forms of Sc(III) in aqueous solutions of HCl and NaOH at 20 ng/ml Sc(III), according to calculations [21].

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4. Fig. 3. Comparison of the degree of Sc(III) sorption obtained in this work with the sizes of TAN (a), STP (b) and ox-STP (c) aggregates [20].

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