Inclusion Complex of Nitrate γ-Cyclodextrine with Conjugate of Tetrahydrocarbasol and Aminoadamantane

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

The possibility of obtaining the inclusion complex of γ-cyclodextrin nitrate with tetrahydrocarbazole and aminoadamantane conjugate, a promising drug for the treatment of neurodegenerative diseases, was investigated and proved using XRD, DSC, HPLC and NMR. It was found that the obtained complex, unlike the active substance itself, is soluble in water, and its cellular toxicity does not exceed that of the active substance, which contributes to the increase of its bioavailability and provides the possibility of conducting the necessary biological studies. It was found that the formed inclusion complex preserves the medicinal properties of the active substance, exhibiting mitoprotective and microtubule-stabilizing activities, and also possesses a pronounced antioxidant activity, effectively inhibiting spontaneous lipid peroxidation in rat brain homogenate.

Авторлар туралы

Yu. Mikhailov

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru

Academician of the RAS

Ресей, 142432 Chernogolovka

S. Bachurin

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru

Academician of the RAS

Ресей, 142432 Chernogolovka

A. Darovskikh

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Хат алмасуға жауапты Автор.
Email: avd@icp.ac.ru
Ресей, 142432 Chernogolovka

I. Veselov

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Ресей, 142432 Chernogolovka

P. Shevtsov

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Ресей, 142432 Chernogolovka

A. Maltsev

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Ресей, 142432 Chernogolovka

E. Shevtsova

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Science

Email: avd@icp.ac.ru
Ресей, 142432 Chernogolovka

Әдебиет тізімі

  1. Кедик С.А., Панов А.В., Тюкова В.С., Золотарева М.С. // Разработка и регистрация лекарственных средств. 2016. № 3. С. 68–75.
  2. Morin-Crini N., Fourmentin S., Fenyvesi E., Lichtfouse E., Torri G., Fourmentin M., Crini G. // Environ. Chem. Lett. 2021. V. 19. P. 2581–2617. https://doi.org/10.1007/s10311-020-01156-w
  3. Loftsson T., Duchêne D. // Int. J. Pharm. 2007. V. 329. P. 1–11. https://doi.org/10.1016/j.ijpharm.2006.10.044
  4. Morina D., Sessevmez M., Sinani G., Mülazımoğlu L., Cevher E. // J. Drug Delivery Sci. Technol. 2020. V. 57. P. 101742. https://doi.org/10.1016/J.Jddst.2020.101742
  5. Paczkowska M., Szymanowska-Powałowska D., Mizera M., Siąkowska D., Błaszczak W., Piotrowska-Kempisty H., Cielecka-Piontek J. // PloS ONE. 2019. V. 14. № 1. P. 1–22. https://doi.org/10.1371/journal.pone.0210694
  6. Ciceu A., Balta C., Herman H., Gharbia S., Ignat S., Dinescu S., Váradi J., Fenyvesi F., Gyöngyösi S., Hermenean A., Costache M. // Int. J. Mol. Sci. 2021. V. 22. 1869. https://doi.org/10.3390/ijms22041869
  7. Popielec A., Loftsson T. // Int. J. Pharm. 2017. V. 531. P. 532–542. https://doi.org/10.1016/j.ijpharm.2017.06.009
  8. Ventura C., Puglisi G., Zappalà M., Mazzone G. // Int. J. Pharm. 1998. V. 160. P. 163–172. https://doi.org/10.1016/S0378-5173(97)00317-7
  9. Ikeda Y., Kimura K., Hirayama F., Arima H., Uekama K. // J. Cont. Rel. 2000. V. 66. P. 271–280. https://doi.org/10.1016/S0168-3659(99)00286-2
  10. Yano H., Hirayama F., Kamada M., Arima H., Uekama K. // J. Cont. Rel. 2002. V. 79. № 1–3. P. 103–112. https://doi.org/10.1016/S0168-3659(01)00532-6
  11. Bounaceur A., Rodier E., Fages J. // Proceedings of the 10th European meeting on supercritical fluids, 12–14 December, 2005, Strasbourg/Colmar, France. P. hal-01781664.
  12. Malaekeh-Nikouei B., Tabassi S., Gerayeli G., Salmani M., Gholamzadeh A. // J. Incl. Phenom. Macrocycle Chem. 2012. V. 72. № 3. P. 383–387. https://doi.org/10.1007/s10847-011-9992-8
  13. Yusuff N.T., York P., Chrystyn H., Bramley P.N., Swallow R.D., Tuladhar B.R., Losowsky M.S. // Eur. J. Clin. Pharmacol. 1991. V. 40. № 5. P. 507–511. https://doi.org/10.1007/bf00315231
  14. Романова Л.Б., Баринова Л.С., Лагодзинская Г.В., Казаков А.И., Михайлов Ю.М. // ЖПХ. 2014. Т. 87. № 12. С. 1809–1815. https://doi.org/10.1134/S1070427214120155
  15. Михайлов Ю.М., Романова Л.Б., Тарасов А.Е., Рахимова М.А., Даровских А.В., Баринова Л.С. // ЖПХ. 2018. Т. 91. № 7. С. 1049–1054. https://doi.org/10.1134/S1070427218070224
  16. Gruenhut N., Cushing M., Caesar G. // J. Am. Chem. Soc. 1948. V. 70. № 1. P 424–425. https://doi.org/10.1021/ja01181a517
  17. Consaga J.P., Collignon S.L. Energetic composites of cyclodextrin nitrate esters and nitrate ester plasticizers. US Patent 5114506. 1992.
  18. Consaga J., Gill R. Energetic Materials. Production, Processing, and Characterization // Proceedings of the 29th Int. Annual Conf. of ICT, Karlsruhe, Germany. June 30–July 3. 1998. pp. V5-1–V5-6.
  19. Михайлов Ю.М., Романова Л.Б., Рахимова М.А., Даровских А.В., Тарасов А.Е., Ковалев Д.Ю., Сиротина А.П. // ЖПХ. 2022. Т. 95. № 1. С. 36–41. https://doi.org/10.31857/S0044461822010042
  20. Maksimowski P., Grzegorczyk A., Cieślak K., Gołofit T., Chmielarek M., Tomaszewski W., Pawłowski W. // Propell., Explos. Pyrotech. 2019. V. 44. P. 207–216. https://doi.org/10.1002/prep.201800301
  21. Maksimowski P., Rumianowski T. // Central European Journal of Energetic Materials. 2016. V. 13. P. 217–229.
  22. Михайлов Ю.М., Рахимова М.А., Романова Л.Б., Даровских А.В. О получении и свойствах нитратов циклодекстринов, сверхразветвленных полиглицидолов и некоторых других гидроксилсодержащих соединений // Сборник трудов Всероссийской конференции “Химия нитросоединений и родственных азот-кислородных систем” (АКС-2019), 23–25 октября 2019 г., Москва, Россия. М.: МАКС Пресс, 2019. С. 15–18. https://doi.org/10.29003/m712.aks-2019/15-18
  23. Михайлов Ю.М., Романова Л.Б., Рахимова Л.А., Даровских А.В., Тарасов А.Е., Баринова Л.С. Ковалев Д.Ю. // Боеприпасы и высокоэнергетические конденсированные системы. 2023. № 2. С. 4–10.
  24. Михайлов Ю.М., Даровских А.В., Романова Л.Б., Рахимова М.А., Климанова Е.Н., Файнгольд И.И. // Технологии безопасности жизнедеятельности. 2023. № 3. С. 5–14. https://doi.org/10.17223/7783494/3/1
  25. Ory D., Ottinger E., Farhat N., King K., Jiang X., Weissfeld L., Berry-Kravis E., Davidson C., Bianconi S., Keener L., Rao R., Soldatos A., Sidhu R., Walters K., Xu X., Thurm A., Solomon B., Pavan W., Machielse B., Kao M., Silber S., McKew J., Brewer C., Vite C., Walkley S., Austin C., Porter F. // Lancet. 2017. V. 390. P. 1758–1768. https://doi.org/10.1016/S0140-6736(17)31465-4
  26. Bar-On P., Rockenstein E., Adame A., Ho G., Hashimoto M., Masliah E. // J. Neurochem. 2006. V. 98. P. 1032–1045. https://doi.org/10.1111/j.1471-4159.2006.04017.x
  27. Kovacs T., Nagy P., Panyi G., Szente L., Varga Z., Zakany F. // Pharmaceutics. 2022. V. 14. P. 2559. https://doi.org/10.3390/pharmaceutics14122559
  28. Angelova P.R., Vinogradova D., Neganova M.E., Serkova T.P., Sokolov V.V., Bachurin S.O., Shevtsova E.F., Abramov A.Y. // Mol. Neurobiol. 2019. V. 56. P. 2244–2255. https://doi.org/10.1007/s12035-018-1204-8
  29. Bachurin S.O., Shevtsova E.F., Makhaeva G.F., Grigoriev V.V., Boltneva N.P., Kovaleva N.V., Lushchekina S.V., Shevtsov P.N., Neganova M.E., Redkozubova O.M., Bovina E.V., Gabrelyan A.V., Fisenko V.P., Sokolov V.B., Aksinenko A.Y., Echeverria V., Barreto G.E., Aliev G. // Sci. Rep. 2017. V. 7. P. 45627 https://doi.org/10.1038/srep45627
  30. Ванин А.Ф. // Вестник Российской АМН. 2000. № 4. С. 3–5.
  31. Гуманова Н.Г. // Профилактическая медицина. 2021. Т. 24. № 9. С. 102–109. https://doi.org/10.17116/profmed202124091102
  32. Мартусевич А.К., Ванин А.Ф. // Биорадикалы и антиоксиданты. 2016. Т. 3. № 3. С. 206–207
  33. Sokolov V.B., Aksinenko A.Yu., Goreva Т. V., Epishina T.A., Grigor´ev V.V., Gabrel´yan A.V., Vinogradova D.V., Neganova M.E., Shevtsova E.F., Bachurin S.O. // Russ. Chem. Bull. 2016. V. 65. P. 1354–1359. https://doi.org/10.1007/s11172-016-1461-5
  34. Bachurin S.O., Shevtsova E.F., Makhaeva G.F., Aksinenko A.Y., Grigoriev V.V., Goreva Т. V., Epishina T.A., Kovaleva N.V., Boltneva N.P., Lushchekina S.V., Rudakova E.V., Vinogradova D.V., Shevtsov P.N., Pushkareva E.A., Dubova L.G., Serkova T.P., Veselov I.M., Fisenko V.P., Richardson R.J. // Int. J. Mol. Sci. 2022. V. 23. P. 13925. https://doi.org/10.3390/ijms232213925

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Russian Academy of Sciences, 2024