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It has been determined that approximately 10% of patients without cardiovascular disease undergoing non-cardiac surgery (NS) suffer myocardial injury (MI) and have a 10% risk of death within 30 days after Sur. Preoperative stress (PS) increases the risk of MI after NS (MINS). The mechanisms of MINS are not well understood. The consequence of many NS is physical inactivity with the development of weakness and fatigue. To date, the relationship between NS and changes in the morphofunctional state of muscles in the postoperative period has been poorly studied. This study reveals for the first time, that metabolic and hormonal changes induced by PS+NS, as well as NS itself and inhalational anesthesia in C57BL/6 mice, are causal factors underlying the mechanisms of MINS in the postoperative period. It was also discovered for the first time, that even low values of the triglyceride-glucose index can indicate ischemic/hypoxic damage of the myocardium and skeletal muscles. Preoperative stress significantly impaired morphofunctional state of the studied organs. More research is needed on the effects of PS and NS on myocardium and muscle performance, as well as the risks and benefits of perioperative treatment.