Efficacy of ivabradine in combination therapy for complicated acute coronary syndrome in patients with type 2 diabetes mellitus
- 作者: Kondrat'ev A.I.1, Dolgikh V.T.1, Stotskiy A.O.1, Kondratyev AI2, Dolgikh VT3, Stotsky AO2
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隶属关系:
- Town Emergency Care Clinical Hospital One
- Omsk State Medical Academy, Ministry of Health and Social Development
- 期: 卷 82, 编号 1 (2010)
- 页面: 27-31
- 栏目: Editorial
- ##submission.dateSubmitted##: 13.04.2020
- ##submission.datePublished##: 15.01.2010
- URL: https://ter-arkhiv.ru/0040-3660/article/view/33378
- ID: 33378
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Subjects and methods. Thirty-six T2DM patients (mean age 56 ± 4.3 years) with a diagnosis of acute coronary syndrome were examined. Eighteen healthy individuals were examined as an age- and gender-matched control group. Metabolic, hemodynamic, and electrophysiological parameters were studied in all the patients on hospital stay days 1 and 5.
Results. Ivabradine used in combination therapy for unstable angina caused reductions in the clinical manifestations of ALVF, heart rate, the number of myocardial ischemic episodes. In the ivabradine-treated patients, left ventricular ejection fraction showed a significant trend for increase. No adverse reactions were recorded.
Conclusion. Ivabradine therapy demonstrated antiischemic and antianginal efficiencies and a good tolerability, without leading to the development of tolerance and without being followed by the development of the withdrawal syndrome.
作者简介
Arkadiy Kondrat'ev
Email: arca_2004@mail.ru
Vladimir Dolgikh
Aleksandr Stotskiy
A Kondratyev
Town Emergency Care Clinical Hospital OneTown Emergency Care Clinical Hospital One
V Dolgikh
Omsk State Medical Academy, Ministry of Health and Social DevelopmentOmsk State Medical Academy, Ministry of Health and Social Development
A Stotsky
Town Emergency Care Clinical Hospital OneTown Emergency Care Clinical Hospital One
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