Hypolipidemic and pleiotropic effects of a combination of simvastatin and ezetimibe in patients with different types of hyperlipidemia
- 作者: Sumarokov AB1, Kukharchuk VV1
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隶属关系:
- 期: 卷 86, 编号 12 (2014)
- 页面: 107-115
- 栏目: Editorial
- ##submission.dateSubmitted##: 10.04.2020
- ##submission.datePublished##: 15.12.2014
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31639
- ID: 31639
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The review considers trials dealing with the efficiency of combination hypolipidemic therapy with simvastatin and ezetimibe. Its synergistic potentiating effect can cause a considerable decrease in the level of total cholesterol, low-density lipoproteins, triglycerides, and C-reactive protein, which are important participants in the atherogenic process. This effect promotes the achievement of hypolipidemic therapeutic goals in many cases when this cannot be attained by high-dose statin monotherapy. The authors consider the results of trials of combination hypolipidemic therapy with simvastatin and ezetimibe performed as basic ones done in both previous and recent years
全文:
Гиполипидемические и плейотропные эффекты комбинации симвастатина и эзетимиба у больных различными видами гиперлипидемий. - Аннотация. В обзоре рассмотрены работы по применению комбинированной гиполипидемической терапии симвастатином и эзетимибом. Синергичный потенцирующий эффект позволяет вызвать значительное снижение уровня общего холестерина, липопротеидов низкой плотности, триглицеридов, а также С-реактивного белка - важных участников процесса атерогенеза. Этот эффект способствует достижению целевого уровня гиполипидемической терапии во многих случаях, когда его не удается достичь с помощью монотерапии высокими дозами статинов. Рассмотрены результаты работ как основных, так и проведенных в последние годы, касающиеся комбинированной гиполипидемической терапии симвастатином и эзетимибом.×
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