Extremely high concentration of mexotrexate in blood serum leading to development of acute renal failure in a patient with acute lymphoblastic leukemia after high-dose consolidation


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Acute renal failure (ARF) is one of rare and severe methotrexate(MT)-induced complications in patients with acute lymphoblastic leukemia. A case of MT-induced renal dysfunction with an extremely high serum MT concentration is reported. This toxicity required conduction of hemodiafiltration for extracorporeal MT elimination. The presence of homozygous mutation of methylene-tetrahydrofolate reductase reflects an individual metabolism of MT and its renal clearance.

作者简介

Mariya Pimenova

Email: maria_pimenova@mail.ru

Andrey Sokolov

Email: cat@blood.ru

Lyudmila Biryukova

Email: birjukova@blood.ru

Elena Ustinova

Inna Shaforostova

Email: shiil@yandex.ru

Irina Donskova

Email: irina.donskova99@mail.ru

Rashit Bogdanov

Email: rashit85@mail.ru

Elena Parovichnikova

Email: elenap@blood.ru

Valeriy Savchenko

Email: svg@blood.ru

M Pimenova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

A Sokolov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

L Biryukova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

E Ustinova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

I Shaforostova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

I Donskova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

R Bogdanov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

E Parovichnikova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

V Savchenko

Hematological Research Center, Moscow

Hematological Research Center, Moscow

参考

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