Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009

Elena Nikolaevna Parovichnikova; Паровичникова Елена Николаевна; G A Klyasova; Клясова Г А; V G Isaev; Исаев В Г; A N Sokolov; Соколов А Н; A V Kokhno; Кохно А В; V V Troitskaya; Троицкая В В; E V Mavrina; Маврина Е В; E E Khodunova; Ходунова Е Е; E N Ustinova; Устинова Е Н; E O Gribanova; Грибанова Е О; S K Kravchenko; Кравченко С К; V V Ryzhko; Рыжко В В; T S Kaporskaya; Капорская Т С; O Yu Baranova; Баранова О Ю; S N Bondarenko; Бондаренко С Н; A S Nizametdinova; Низаметдинова А С; E V Kondakova; Кондакова Е В; T V Ryl'tsova; Рыльцова Т В; A N Alufer'eva; Алуферьева А Н; O S Samoylova; Самойлова О С; O P Skamorina; Скаморина О П; L V Gavrilova; Гаврилова Л В; A S Pristupa; Приступа А С; N A Vopilina; Вопилина Н А; T S Konstantinova; Константинова Т С; I V Kryuchkova; Крючкова И В; L V Anchukova; Анчукова Л В; T S Tikunova; Тикунова Т С; K D Kaplanov; Капланов К Д; V A Lapin; Лапин В А; V A Tumakov; Тумаков В А; M N Kozmina; Козмина М Н; S A Chernysh; Черныш С А; E I Podol'tseva; Подольцева Э И; S M Kulikov; Куликов С М; Yu R Davidyan; Давидян Ю Р; V G Savchenko; Савченко В Г; E N Parovichnikova; Parovichnikova E N; G A Klyasova; Klyasova G A; V G Isaev; Isaev V G; A N Sokolov; Sokolov A N; A V Kokhno; Kokhno A V; V V Troitskaya; Troitskaya V V; E V Mavrina; Mavrina E V; E E Khodunova; Khodunova E E; E N Ustinova; Ustinova E N; E O Gribanova; Gribanova E O; S K Kravchenko; Kravchenko S K; V V Ryzhko; Ryzhko V V; T S Kaporskaya; Kaporskaya T S; O Yu Baranova; Baranova O Yu; S N Bondarenko; Bondarenko S N; A S Nizametdinova; Nizametdinova A S; E V Kondakova; Kondakova E V; T V Ryltsova; Ryltsova T V; A N Aluferieva; Aluferieva A N; O S Samoilova; Samoilova O S; O P Skamorina; Skamorina O P; L V Gavrilova; Gavrilova L V; A S Pristupa; Pristupa A S; N A Vopilina; Vopilina N A; T S Konstantinova; Konstantinova T S; I V Kryuchkova; Kryuchkova I V; L V Anchukova; Anchukova L V; T S Tikunova; Tikunova T S; K D Kaplanov; Kaplanov K D; V A Lapin; Lapin V A; V A Tumakov; Tumakov V A; M N Kozmina; Kozmina M N; S A Chernysh; Chernysh S A; E I Podoltseva; Podoltseva E I; S M Kulikov; Kulikov S M; Yu R Davidyan; Davidyan Yu R; V G Savchenko; Savchenko V G

Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009

作者: Parovichnikova E.N.¹, Klyasova GA¹, Isaev VG¹, Sokolov AN¹, Kokhno AV¹, Troitskaya VV¹, Mavrina EV¹, Khodunova EE¹, Ustinova EN¹, Gribanova EO¹, Kravchenko SK¹, Ryzhko VV¹, Kaporskaya TS¹, Baranova OY.¹, Bondarenko SN¹, Nizametdinova AS¹, Kondakova EV¹, Ryl'tsova TV¹, Alufer'eva AN¹, Samoylova OS¹, Skamorina OP¹, Gavrilova LV¹, Pristupa AS¹, Vopilina NA¹, Konstantinova TS¹, Kryuchkova IV¹, Anchukova LV¹, Tikunova TS¹, Kaplanov KD¹, Lapin VA¹, Tumakov VA¹, Kozmina MN¹, Chernysh SA¹, Podol'tseva EI¹, Kulikov SM¹, Davidyan Y.R¹, Savchenko VG¹, Parovichnikova EN², Klyasova GA², Isaev VG², Sokolov AN², Kokhno AV², Troitskaya VV², Mavrina EV², Khodunova EE², Ustinova EN², Gribanova EO², Kravchenko SK², Ryzhko VV², Kaporskaya TS³, Baranova OY.⁴, Bondarenko SN⁵, Nizametdinova AS⁶, Kondakova EV⁷, Ryltsova TV⁸, Aluferieva AN⁹, Samoilova OS¹⁰, Skamorina OP¹¹, Gavrilova LV¹², Pristupa AS¹³, Vopilina NA¹⁴, Konstantinova TS¹⁵, Kryuchkova IV¹⁶, Anchukova LV¹⁷, Tikunova TS¹⁸, Kaplanov KD¹⁹, Lapin VA²⁰, Tumakov VA²¹, Kozmina MN²², Chernysh SA²³, Podoltseva EI²⁴, Kulikov SM², Davidyan Y.R², Savchenko VG²
隶属关系:
2. Hematological Research Center, Moscow
3. Regional hospital, Irkutsk
4. N.N. Blokhin Russian Cancer Research Center
5. State Medical University, St-Petersburg
6. City hospital N 17, St-Petersburg
7. Regional hospital, Surgut
8. Regional hospital, Tula
9. Regional hospital, Samara
10. Regional hospital, N. Novgorod
11. Central hospital of GSS, Moscow
12. Regional hospital, Saransk
13. Regional hospital, Ryazan
14. Regional hospital, Tambov
15. Regional hospital, Ekaterinburg
16. Research Clinical Institute, Novosibirsk
17. Regional hospital, Vologda
18. Regional hospital, Belgorod
19. Regional hospital, Volgograd
20. Regional hospital, Yaroslavl
21. Regional hospital, Ivanovo
22. Regional hospital, Orel
23. S.P. Botkin City hospital, Moscow
24. City hospital N 23, St-Petersburg
期: 卷 83, 编号 7 (2011)
页面: 11-17
栏目: Editorial
##submission.dateSubmitted##: 10.04.2020
##submission.datePublished##: 15.07.2011
URL: https://ter-arkhiv.ru/0040-3660/article/view/30852
ID: 30852

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Aim. To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009.
Material and methods. Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF.
Results. Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype.
Conclusion. Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center.

关键词

adult Ph-negative acute lymphoblastic leukemia, sensitivity to prednisolone, L-asparaginasa

参考

Паровичникова Е. Н., Савченко В. Г., Давидян Ю. Р. и др. Итоги лечения острых лимфобластных лейкозов взрослых по протоколу ОЛЛ-2005 как основа для новых исследований. Тер. арх. 2009; 7: 8-16.
Daves M. H., Hunger S., Linda S. B. et al. Longer time to the start of continuation therapy is associated with improved survival in high risk pediatric acute lumphoblastic leukemia(ALL): a report from the Children's Oncology Group (COG). Blood 2010; 116 (21): 1322 , abstr. 3223.
Stive J. I., Buck G., Fielding A. et al. Inability to tolerate standard therapy is a major reason for poor outcome in older adults with acute lymphoblastic leukemia (ALL): results from international MRC/ECOG trial. Blood 2010; 116 (21): 218-219 , abstr. 493.
Goekbuget N., Baumann A., Beck J. et al. PEG-Asparaginase intensification in adult acute lymphoblastic leukemia (ALL): significant improvement of outcome with moderate increase of liver toxicity in the German multicenter study group for adult ALL (GMALL) study 07/2003. Blood 2010; 116 (2l): 219- 220 , abstr. 494.
Rytting M. E., Kantarjian H., Thomas D. A. et al. Adolescent and young adult patients treated with modified augmented Berlin-Frankfurt-Muenster therapy. Blood 2010; 116 (21): 1333, abstr. 3250.
Bassan R., Intermesoli T, Mascuilli A. et al. Pediatric type therapy including lineage-targeted methotrexate to improve eraly minimal residual disease response and survival in adult acute lymphoblastic leukemia (ALL): interim analysis of Northern Italy leukemia group study 10/07. Blood 2010; 116(21): 881- 882, abstr. 2131.

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Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009

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