Use of a nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension

Ol'ga Aleksandrovna Arkhipova; Архипова Ольга Александровна; Tamila Vital'evna Martynyuk; Мартынюк Тамила Витальевна; Valentina Kirillovna Lazutkina; Лазуткина Валентина Кирилловна; Dil'bar Mukumovna Ataullakhanova; Атауллаханова Дильбар Мукумовна; Ol'ga Vladimirovna Stukalova; Стукалова Ольга Владимировна; Nikolay Mikhaylovich Danilov; Данилов Николай Михайлович; Lyudmila Evgen'evna Samoylenko; Самойленко Людмила Евгеньевна; Irina Evgen'evna Chazova; Чазова Ирина Евгеньевна; O A Arkhipova; Arkhipova O A; T V Martynyuk; Martynyuk T V; V K Lazutkina; Lazutkina V K; D M Ataullakhanova; Ataullakhanova D M; O V Stukalova; Stukalova O V; N M Danilov; Danilov N M; L E Samoilenko; Samoilenko L E; I E Chazova; Chazova I E

Use of a nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension

作者: Arkhipova O.A.¹, Martynyuk T.V.¹, Lazutkina V.K.¹, Ataullakhanova D.M.¹, Stukalova O.V.¹, Danilov N.M.¹, Samoylenko L.E.¹, Chazova I.E.¹, Arkhipova OA², Martynyuk TV², Lazutkina VK², Ataullakhanova DM², Stukalova OV², Danilov NM², Samoilenko LE², Chazova IE²
隶属关系:
2. Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
期: 卷 82, 编号 11 (2010)
页面: 70-73
栏目: Editorial
##submission.dateSubmitted##: 09.04.2020
##submission.datePublished##: 15.11.2010
URL: https://ter-arkhiv.ru/0040-3660/article/view/30759
ID: 30759

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详细

Idiopathic (primary) pulmonary hypertension (IPH) is a rare disease of unknown etiology, which is characterized by elevated pulmonary artery pressure, increased total pulmonary vascular resistance, frequently a malignant course with evolving right ventricular decompensation, and a fatal outcome. The diagnosis of IPH is established on the increments in the mean resting and exercise pulmonary artery trunk pressure by more than 25 and more than 30 mm Hg at rest and during exercise, respectively, with a normal pulmonary artery wedge pressure.
Endothelin receptor antagonists (ERA) are one of the effective classes of drugs for the treatment of patients with IPH. Bosentan is the first drug from the ERA class that blocks the receptors of both types and that has been recommended by the WHO to treat patients with functional class II-IV pulmonary hypertension.
The described case demonstrates the possibility of concomitantly using bosentan in a female patient with IPH shortly after ineffective treatment with a calcium antagonist.

关键词

idiopathic pulmonary hypertension, clinical and instrumental characteristics, treatment, dilthiazem, bosentan (traclin)

参考

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Humbert M., Sitbon O., Simonneau G. Treatment of pulmonary arterial hypertension. N. Engl. J. Med. 2004; 351: 1425-1436.
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Channick R. N., Simonneau G., Sitbon O. et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with primary hypertension: a randomized placebo-controlled study. Lancet 2001; 358: 1119-1123.

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Use of a nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension

全文:

详细

关键词

作者简介

Ol'ga Arkhipova

Tamila Martynyuk

Valentina Lazutkina

Dil'bar Ataullakhanova

Ol'ga Stukalova

Nikolay Danilov

Lyudmila Samoylenko

Irina Chazova

O Arkhipova

T Martynyuk

V Lazutkina

D Ataullakhanova

O Stukalova

N Danilov

L Samoilenko

I Chazova

参考

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