电邮这篇文章 Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment
- 作者: Yatsyshina S.B.1, Minenko A.N.1, Kushakova T.E.1, Praded M.N.1, Kudryavtseva A.V.1, Shipulin G.A.1, Maleev V.V.1, Pokrovskiy VI1, Yatsyshina SB2, Minenko AN2, Kushakova TE2, Praded MN2, Kudryavtseva AV2, Shipulin GA2, Maleyev VV2, Pokrovsky VI2
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隶属关系:
- Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
- 期: 卷 82, 编号 11 (2010)
- 页面: 10-14
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.11.2010
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30689
- ID: 30689
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Subjects and methods. Materials from 874 patients, including postmortem samples from 287 subjects, were examined applying the AmpliSens Influenza virus A/H1-swine-FL PCR kit designed and produced by the Central Research Institute of Epidemiology. The clinical and postmortem characteristics of 68 patients who had died from influenza A/H1N1 (sw2009) were analyzed in detail.
Results. The cause of deaths was primary virus pneumonia in most cases. The major manifestation of viral pathogenicity was impaired microcirculation leading to hemorrhage. No mutations conferring resistance to oseltamivir and arbidol were found. All A/H1N1swl viruses had genetic markers of remantadin resistance.
Conclusion. The reagent kits developed by the Central Research Institute of Epidemiology proved to be effective. It is necessary to set up PCR laboratories that differentially diagnose influenza and acute respiratory viral infections in health care facilities in order to make early laboratory diagnosis of influenza and to timely perform its specific therapy.
作者简介
Svetlana Yatsyshina
Email: syatsyshin@pcr.ru
Andrey Minenko
Tat'yanaya Kushakova
Mariya Praded
Anna Kudryavtseva
German Shipulin
Viktor Maleev
V Pokrovskiy
S Yatsyshina
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
A Minenko
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
T Kushakova
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
M Praded
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
A Kudryavtseva
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
G Shipulin
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
V Maleyev
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
V Pokrovsky
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
参考
- WHO Pandemic (H1N1) 2009 - update 98/ http:// www.who.int/csr/don/2010_04_30a/en/index.html
- CDC Estimates of 2009 H1N1 Influenza Cases, Hospitalizations and Deaths in the United States, April 2009 - March 13, 2010. www.cdc.gov/h1n1flu/estimates_2009_h1n1.htm
- Письмо Роспотребнадзора № 01/5578-10-32 от 13.04.2010 "Об итогах пандемии гриппа A/H1N1/09 в мире и Российской Федерации в эпидсезон 2009-2010 гг." и прогнозе на эпидсезон 2010-2011 гг." М.; 2010.
- Geiss G. K., Salvatore M., Tumpey T. M. et al. Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: The role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza. Proc. Nath. Acad. Sci. USA 2002; 99(16): 10736-10741.
- Ритова В. В. Грипп у детей раннего возраста. Этиология, эпидемиология и специфическая профилактика: Автореф. дис. ... д-ра мед. наук. М.; 1956.
- Fraser C., Donnelly C., Cauchemez S. et al. Pandemic potential of a strain of influenza A(H1N1): early findings. Science 2009; 324(5934): 1557-1561.
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