Clinical and epidemiological features of Berkitt's lymphoma


Cite item

Full Text

Abstract

Aim. To characterize clinical and epidemiological features of adult Berkitt's lymphoma (BL).
Material and methods. The trial enrolled 72 patients (51 males and 21 females, age 14-69, mean age 27 years) treated in 1995-2008.
Results. Stage I BL (by S.B. Murphy) was diagnosed in 5 patients, stage II - in 9, stage III - in 25, IV - in 14 patients, B-cell acute lymphoblastic leukemia (ALL) (L3) - in 19 patients. Intoxication was seen in 56(78%) patients, 38% patients had severe cachexia. Elevated concentration of lactatedehydrogenase (LDG) was detected in 57(79%) patients. In all the cases clinical symptoms developed for 1-3 months, median 6 weeks. Bone marrow involvement was diagnosed in 22 (31%) patients, CNS was affected in 17(24%) patients, of them 14 were males. Fifty two (72%) patients had abdominal, retroperitoneal and/or small pelvis tumors. Intestinal, hepatic, renal and gastric tumors occurred most frequently. Specific ascitis was detected in 25(48%), tumor pleuritis - in 11(15%) patients. BL of the facial skeleton, Waldeyer's ring, oro- and nasopharynx was in 12(17%) patients. Seven patients had concomitant involvement of the CNS. Eight (38%) and 2(10%) women had tumors of the ovaries and uterus, respectively.
Conclusion. BL is characterized by the following clinical features: young age of the patients, most of them are males, B-symptoms, short history, generalized stages, extranodal lesions, frequent involvement of the bone marrow and CNS.

References

  1. Барях Е. А. Лимфома Беркитта и беркиттоподобные лимфомы. В кн.: Воробьев А. И., Кременецкая А. М. (ред.). Атлас "Опухоли лимфатической системы". М.: Ньюдиамед, 2007. 154-167.
  2. De-The G. Epidemiologie of Burkitt's lymphoma: evidance for a casual association with EBV. Epidemiol. Rev. 1979; 36: 692-698.
  3. Oguonu T., Emodi E., Kaine W. Epidimiologie of Burkitt's lymphoma in Enugu, Nigeria. Ann. Trop. Paediatr. 2002; 22: 369-374.
  4. Ziegler J. L. Burkitt's lymphoma. N. Engl. J. Med. 1981; 305: 735-745.
  5. Аль-Мадхажжи А. А. Клинические и сероэпидемиологические особенности лимфомы Беркитта в Республике Йемен: Автореф. дис. ... канд. мед. наук. М.; 1998.
  6. Blum K. A., Lozansky G., Byrd J. Adult Burkitt's leukemia and lymphoma. Blood 2004; 104(10): 3009-3020.
  7. Shad A., Magrath I. Non Hodgkin's lymphoma. Pediatr. Clin. Am. 1997; 44: 863-890.
  8. Levine A. M. Acquired immunodeficiency syndrome-related lymphoma. Blood 1992; 80: 8-20.
  9. Spina M., Tirelli U., Zagonel V. et al. Burkitt's lymphoma in adult with and without immunodeficiency virus infection. A single-institution clinicopathologic study of 75 patients. Cancer 1998; 82(4): 766-774.
  10. Барях Е. А. Диагностика и лечение лимфомы Беркитта: Автореф. дис. ... канд. мед. наук. М.; 2007.
  11. Lazzi S., Ferrari F., Nyong'o A. et al. HIV-associated malignant lymphomas in Kenya (equatorial Africa). Hum. Pathol. 1998; 29: 1285-1289.
  12. Hoelther D., Ludwid W. D., Thiel E. et al. Improved outcome in adult B-cell acute lymphoblastic leukemia. Blood 1996; 87: 495-508.
  13. Thomas D., Cortes J., O'Brien S. et al. Hyper-CVAD program in Burkitt's type adult acute lymphoblastic leukemia. J. Clin. Oncol. 1999; 17: 2461-2470.
  14. Sariban E., Edwards S., Janus C., Magrath I. Central nervous system involvement in American Burkitt's lymphoma. J. Clin. Oncol. 1983; 1: 677-680.
  15. McWilliams N., Hatfield W., Jackson R. Epidemiological notes and reports on Burkitt's lymphoma - Winchester, Virginia. Morbid. Mortal. Wkly Rep. 1997; 46: 4674-4678.
  16. Ardekian L., Rachmiel A., Rosen D. et al. Burkitt's lymphoma of the oral cavity in Israel. J. Craniomaxillofac. Surg. 1999; 27(5): 294-297.
  17. Bauer G. P., Volk M. S., Siddiqui S. Y. Burkitt's lymphoma of the parafaringeal space. Arch. Otolaryngol. Head Neck Surg. 1993; 119(1): 117-120.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies