Clinical and epidemiological features of Berkitt's lymphoma
- 作者: Baryakh E.A.1, Kravchenko S.K.1, Kremenetskaya A.M.1, Zvonkov E.E.1, Obukhova T.N.1, Magomedova A.U.1, Vorob'ev A.I.1, Baryakh EA1, Kravchenko SK1, Kremenetskaya AM1, Zvonkov EE1, Obukhova TN1, Magomedova KU1, Vorobyev AI1
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- 期: 卷 81, 编号 7 (2009)
- 页面: 47-53
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.07.2009
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30387
- ID: 30387
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Material and methods. The trial enrolled 72 patients (51 males and 21 females, age 14-69, mean age 27 years) treated in 1995-2008.
Results. Stage I BL (by S.B. Murphy) was diagnosed in 5 patients, stage II - in 9, stage III - in 25, IV - in 14 patients, B-cell acute lymphoblastic leukemia (ALL) (L3) - in 19 patients. Intoxication was seen in 56(78%) patients, 38% patients had severe cachexia. Elevated concentration of lactatedehydrogenase (LDG) was detected in 57(79%) patients. In all the cases clinical symptoms developed for 1-3 months, median 6 weeks. Bone marrow involvement was diagnosed in 22 (31%) patients, CNS was affected in 17(24%) patients, of them 14 were males. Fifty two (72%) patients had abdominal, retroperitoneal and/or small pelvis tumors. Intestinal, hepatic, renal and gastric tumors occurred most frequently. Specific ascitis was detected in 25(48%), tumor pleuritis - in 11(15%) patients. BL of the facial skeleton, Waldeyer's ring, oro- and nasopharynx was in 12(17%) patients. Seven patients had concomitant involvement of the CNS. Eight (38%) and 2(10%) women had tumors of the ovaries and uterus, respectively.
Conclusion. BL is characterized by the following clinical features: young age of the patients, most of them are males, B-symptoms, short history, generalized stages, extranodal lesions, frequent involvement of the bone marrow and CNS.
作者简介
Elena Baryakh
Email: baryakh@mail.ru
Sergey Kravchenko
Email: krav@blood.ru
Aleksandra Kremenetskaya
Email: mtkalexandra@gmail.com
Evgeniy Zvonkov
Email: zvonkov@blood.ru
Tat'yana Obukhova
Email: obukhova@blood.ru
Aminat Magomedova
Email: maminat@mail.ru
Andrey Vorob'ev
E Baryakh
S Kravchenko
A Kremenetskaya
E Zvonkov
T Obukhova
K Magomedova
A Vorobyev
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