Dasatinib treatment of imatinib-resistant and imatinib-intolerant patients with chronic myeloid leukemia in a chronic phase
- Authors: Vinogradova O.Y.1, Turkina A.G.1, Vorontsova A.V.1, Chelysheva E.Y.1, Gusarova G.A.1, Kuznetsov SV1, Goryacheva S.R.1, Sokolova M.A.1, Abakumov E.M.1, Stakhina O.V.1, Domracheva E.V.1, Misyurin A.V.1, Khoroshko N.D.1, Vinogradova OY.1, Turkina AG1, Vorontsova AV1, Chelysheva EY.1, Gusarova GA1, Kuznetsov SV1, Goryacheva SR1, Sokolova MA1, Abakumov EM1, Stakhina OV1, Domracheva EV1, Misyurin AV1, Khoroshko ND1
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Affiliations:
- Issue: Vol 81, No 7 (2009)
- Pages: 41-46
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30380
- ID: 30380
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Abstract
Material and methods. A total of 18 patients with chronic myeloid leukemia (CML) in a chronic stage received dasatinib for 9-30 months (median 30 months) to September 2008.
Results. Lethal outcomes during dasatinib treatment were absent. To September 2008, 16(89%) patients were alive, 2(11%) patients died of the disease progression after dasatinib discontinuation. A complete clinicohematological response was observed in all the patients. Major cytogenetic, complete cytogenetic, major molecular, complete molecular responses were achieved in 12(67%), 10(55%), 7(39%) and 5(28%) patients, respectively. Hematological and non-hematological toxicity occurred in 9(50%) patients. Now 12(67%) patients continue dasatinib treatment, in 6(33%) patients the drug was discontinued.
Conclusion. The results from trials in Russian Hematological Research Center are the same as in the international study. Dasatinib is effective and well tolerated therapeutic option for imatinib-resistant patients with a chronic phase of CML.
About the authors
Ol'ga Yur'evna Vinogradova
Email: olgavinz@mail.ru
Anna Grigor'evna Turkina
Email: tur@blood.ru
Aleksandra Valer'evna Vorontsova
Email: voroncova9@mail.ru
Ekaterina Yur'evna Chelysheva
Email: denve@bk.ru
Galina Anatol'evna Gusarova
Email: galina1966@bk.ru
S V Kuznetsov
Svetlana Rudol'fovna Goryacheva
Manana Aleksandrovna Sokolova
Email: manana@mail.ru
Evgeniy Mikhaylovich Abakumov
Ol'ga Veniaminovna Stakhina
Email: stakhina@mail.ru
Elena Vasil'evna Domracheva
Email: dom@blood.ru
Andrey Vital'evich Misyurin
Nina Dmitrievna Khoroshko
Email: khoroshko@blood.ru
O Yu Vinogradova
A G Turkina
A V Vorontsova
E Yu Chelysheva
G A Gusarova
S V Kuznetsov
S R Goryacheva
M A Sokolova
E M Abakumov
O V Stakhina
E V Domracheva
A V Misyurin
N D Khoroshko
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