Effects of interferon therapy onfunctional activity of platelets in chronic viral hepatitis andcirrhosis of the liver
- 作者: Yagoda AV1, Koroi PV1
-
隶属关系:
- 期: 卷 79, 编号 8 (2004)
- 页面: 72-73
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.08.2004
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29924
- ID: 29924
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Aim. To characterize effects of interferon alpha (If-a) on functional activity of platelets in patients
with chronic viral hepatitis (CVH) and viral hepatic cirrhosis (VHC).
Material and methods. Induced platelet aggregation (PA), spontaneous PA, levels of cAMP, cGMP
and glycogen in platelets, plasm beta-thromboglobulin (bTG) and activity of thrombocytic factor 4
(TF4) were measured in 95 patients before, 4.5h after the first If-a introduction, after 12 and 24
weeks of If-a treatment.
Results. The patients demonstrated low induced PA, intracellular glycogen and high cAMP, b- TG
amd TF4. The initial administration of If-a led to normalization of most of functional platelet indices.
A 24-h course of If-a therapy normalized platelet functions irrespective of stability of the virusological
response.
Conclusion. If-a preparations in single and multiple administrations normalize platelet function.
with chronic viral hepatitis (CVH) and viral hepatic cirrhosis (VHC).
Material and methods. Induced platelet aggregation (PA), spontaneous PA, levels of cAMP, cGMP
and glycogen in platelets, plasm beta-thromboglobulin (bTG) and activity of thrombocytic factor 4
(TF4) were measured in 95 patients before, 4.5h after the first If-a introduction, after 12 and 24
weeks of If-a treatment.
Results. The patients demonstrated low induced PA, intracellular glycogen and high cAMP, b- TG
amd TF4. The initial administration of If-a led to normalization of most of functional platelet indices.
A 24-h course of If-a therapy normalized platelet functions irrespective of stability of the virusological
response.
Conclusion. If-a preparations in single and multiple administrations normalize platelet function.
参考
- Шерлок Ш., Дули Дж. Заболевания печени и желчевыводяших путей. М.: Гэотар Медицина; 1999.
- Kajihara M., Kato S., Okazaki Y. et al. A role of autoantibody mediated platelet destruction in thrombocytopenia in patients with cirrhosis. Hepatology 2003; 37 (6): 1267-1276.
- Peck-Radosavljevic M., Zacherl J., Afeng Y G et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J. Hepatol. 1997; 27 (1): 127-131.
- Серов Н. А., Коновалова Э. В., Пинигина П. Ю. Тромбоцитопения у больного с HBV-ассоциированным хроническим гепатитом. Рос. журн. гастроэнтерол., гепатол., колопроктол. 2000; 3: 85-86.
- Goubran F., Serwah A.-H., Abdel-Hamid A. et al. Qualitative and quantitative platelet abnormalities in hepatitis С virus associated chronic liver disease. J. Hepatol. 2002; 36 (1): 128.
- Sanchez-Roig M. J., Rivera J., Moraleda J. M., Garcia V. V. Quantitative defect of glycoprotein lb in severe cirrhotic patients. Am. J. Hematol. 1994; 45 (1): 10-15.
- Щетников К. А., Морозова В. Т. Изменения лабораторных показателей системы гемостаза при вирусном гепатите. Клин. лаб. диагн. 1994; 2: 54-55.
- Laffi G, Cinotti S., Filimberti E. et al. Defective aggregation in cirrhosis is independent of in vivo platelet activation. J. Hepa- tol. 1996; 24 (4): 436-444.
- Davi G., Ferro D., Basili S. et al. Increased thromboxane metabolites excretion in liver cirrhosis. Thromb. Haemost. 1998; 79 (4): 747-751.
- Laffi G, Marra F, Gresele P. et al. Evidence for a storage pool defect in platelets from cirrhotic patients with defective aggregation. Gastroenterology 1992; 103: 641-646.
- Yagoda A. V., Koroy P. V. Platelets hemostasis in chronic viral liver diseases during interferon treatment. J. Hepatol. 2002; 36 (1): 114(405).
- Гейвандова Н. И. Медиаторы воспаления в патогенезе, диагностике и лечении хронических вирусных заболеваний печени: Автореф. дис.д-ра мед. наук. М.; 2001.
- Балуда В. ГГ., Балуда М. В., Деянов И. И., Тлепшуков И. К. Физиология системы гемостаза. М.: Медицина; 1995.
- Nakamura N., Shibazaki M., Nitta Y, Endo Y. Translocation of platelet into Disse spaces and their entry into hepatocytes in response to lipopolysaccharides, interleukin-1 and tumor necrosis factor: the role of Kupffer cells. J. Hepatol. 1998; 28 (6): 991-999.
- Shiraishi Т., Morimoto S., Koh E. et al. Increased release of platelet-derived growth factor from platelets in chronic liver disease. Eur. J. Clin Chem. Clin. Biochem. 1994; 32 (1): 5-9.
- Mallat A., Gallois C., Tao J. С et al. Platelet-derived growth factor-BB and thrombin generate positive and negative signals for human hepatic stellate cell proliferation. Role of a prostag landin/cyclic AMF pathway and cross-talk with endothelin receptors. J. Biol. Chem. 1998; 273 (42): 27300-27305.
- Adinolfl L. E., Giordano M. G, Andreana A. et al. Hepatic fi- brosis plays a central role in the pathogenesis of thrombocyto penia in patients with chronic viral hepatitis. Br. J. Haematol. 2001; 113: 590-595.
- Papatheodoridis G, Papakonstantinou £., Andtioti E. et al. Thrombotic risk factors and extent of liver fibrosis in patients with chronic viral hepatitis (CH). J. Hepatol. 2002; 36 (1): 175.
- Peck-Radosavljevic M., Wichlas M., Pidlich J. et al. Blunted thrombopoietin response to interferon alfa-induced thrombocytopenia during treatment for hepatitis С Hepatology 1998; 28 (5): 1424-1429.
- Sata M., Yano Y, Yoshiyama Y. et al. Mechanisms of thrombocytopenia induced by interferon therapy for chronic hepatitisB. J. Gastroenterol. 1997; 32 (2): 206-210.
- Weidekamm C, Kreil A., Pidlich J. et al. Antagonisation of the antiproliferative action of IFN -alpha on megacaryocytic cells lines by thrombopoetin (TPO). J. Hepatol. 2002; 36 (1): 75.
- Wichlas M., Hofer ГГ., Homoncik M. et al. Hematological chances during IFN/Ribavirin combination therapy in patients with chronic hepatitis С J. Hepatol. 2002; 36 (1): 114.
- Colombatto P., Oliveri F., Leandro G. et al. Platelet and white blood cell counts during therapy with different types of alpha interferon in patients with chronic viral hepatitis. Ital. J. Gas troenterol.-Hepatol. 1997; 29 (5): 441-447.
- Homoncik M., Jessner W., Sieghardt W. et al. Effect of therapy with interferon-alpha and pegylated interferon-alpha on plate let plug formation in patients with chronic hepatitis C. J. Hepatol. 2003; 38 (2): 145.
- Полякова А. М., Ломазова К. Д., Кравченко А. В., МалеевВ. В. Действие интерферона и реаферона на функциональную активность тромбоцитов человека. Журн. иммунол., микробиол., вирусол. и эпидемиол. 1989; 11: 52-54.
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