Clinical and biochemical manifestations of chronic pyelonephritis and theircorrection in population of the northen areas of the Tyumen Territory

Aim. To study clinicobiochemical features of chronic pyelonephritis (CPN) in the population of northen areas of the Tyumen Territory; to determine emoxipine effects on CPN treatment efficacy.
Material and methods. Clinicolaboratory manifestations of CPN were studied in 246 CPN patients
(126 residents of the Tyumen South and 120 residents of the Tyumen North, age 18-55, 174 females,
72 males). The control group consisted of 60 healthy subjects of the same gender and age.
Results. CPN in patients living in the north was characterized by more severe intoxication, dysuric
disorders, piuria, arterial hypertension, more intensive restructuring of cellular membranes. Membranopathological changes depend on the phase of the pathological process and clinical form of the disease.
Emoxipin addition to combined therapy of CPN promoted faster correction of basic CPN symptoms
and stabilization of the lipid phase of erythrocytic membranes.
Conclusion. Clinical and biochemical features of CPN in patients living in the Tyumen North represent additional diagnostic criteria of the disease activity. Adjuvant use of the antioxidant drug emoxipin produces a noticeable clinicobiochemical effect.

chronic pyelonephritis, Far North, red cell membranes, antioxidant emoxipin, lipid peroxidation