电邮这篇文章 Propranolol treatment ofeffort angina in patients with arterial hypotension
- 作者: Idrisova EM1, Boschenko AA1, Borovkova NV1, Demochko AV1, Chernov VI1, Karpov RS1
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- 期: 卷 79, 编号 8 (2004)
- 页面: 32-35
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.08.2004
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29882
- ID: 29882
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Aim. To compare antianginal efficacy and tolerability of propranolol therapy in patients with stable
angina pectoris and chronic hypotension (Hpts) and normotensive patients with angina of effort (Npts).
Material and methods. A randomized, single-blind, placebo-controlled study was made in 35 Hpts and 38
Npts was made using bicycle exercise tests, echocardiography, stress myocardial scintigraphy with Tl-199.
Results. Acute bicycle exercise tests showed high anti-ischemic activity of propranolol in 86% Hpts
and 65% Npts. Stable antianginal propranolol effect in 57% Hpts was accompanied with a decrease of
myocardial perfusion defect. Secondary resistance or pseudotolerance to an antianginal effect of pro-
pranolol was observed in 43% Hpts in 4-12 weeks (vs 0 of Npts; p < 0,01) as evidenced by Tl-199
stress myocardial scintigraphy. Hpts with secondary resistance and pseudotolerance to propranolol had
lower control hypotension and bradicardia (p < 0,05), more anginal attacks (p < 0,001).
Conclusion. Hpts had rapidly developing secondary resistance and pseudotolerance to propranolol an-
tianginal effect, bad tolerability of the drug.
angina pectoris and chronic hypotension (Hpts) and normotensive patients with angina of effort (Npts).
Material and methods. A randomized, single-blind, placebo-controlled study was made in 35 Hpts and 38
Npts was made using bicycle exercise tests, echocardiography, stress myocardial scintigraphy with Tl-199.
Results. Acute bicycle exercise tests showed high anti-ischemic activity of propranolol in 86% Hpts
and 65% Npts. Stable antianginal propranolol effect in 57% Hpts was accompanied with a decrease of
myocardial perfusion defect. Secondary resistance or pseudotolerance to an antianginal effect of pro-
pranolol was observed in 43% Hpts in 4-12 weeks (vs 0 of Npts; p < 0,01) as evidenced by Tl-199
stress myocardial scintigraphy. Hpts with secondary resistance and pseudotolerance to propranolol had
lower control hypotension and bradicardia (p < 0,05), more anginal attacks (p < 0,001).
Conclusion. Hpts had rapidly developing secondary resistance and pseudotolerance to propranolol an-
tianginal effect, bad tolerability of the drug.
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