Immunoresistance syndrome in gout patients and its influence on formation of clinical features of the disease


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Aim. To evaluate the occurrence of immunoresistance (IR) syndrome in gout and its correlation with a gout course.
Material and methods. Anthropometric parameters, blood lipid spectrum, levels of glucose, uric acid (UA), immunoreactive insulin, HOMA index were studied in 55 male patients with gout (mean age 50.1 ± 7.9 years, mean duration of the disease 7.5 ± 7.2 years). Statistic processing was made with computer program Statistica 6.0.
Results. IR was revealed in 49% patients. Immunoresistant patients had visceral obesity, arterial hypertension, abnormal lipid profde, high UA concentrations, longer disease, chronic articular syndrome, high occurrence of diabetes mellitus and vascular events significantly more frequently. Conclusion. IR in gout patients is the risk factor of cardiovascular diseases; combination of IR and hyperinsulinemia is characterized by marked hyperuricemia and a trend to chronic course of the articular syndrome. Longer duration of gout, especially treated inadequately, raises the risk of IR. IR deteriorates prognosis in relation to cardiovascular diseases, diabetes mellitus type 2, course of gout itself.

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