Email this article The role of ultrasound dopplerography with an acutecaptopril test in assessing renal hemodynamics in chronicglomerulonephritis
- Authors: Marlynov SA1, Shvetsov MY.1, Kutyrina IM1, Miroshnichenko NG1, Kushnir VV1, Petrov SV1, Struchkova TY.1, Dzhanaliev BR1, Varshavsky VA1, Proskurneva EP1
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Affiliations:
- Issue: Vol 78, No 6 (2003)
- Pages: 41-46
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29378
- ID: 29378
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Abstract
test with captopril in patients with chronic glomerulonephritis (CGN).
Material and methods. Renal circulation was studied in 50 patients with CGN using ultrasound dopplerography
(USDG) of renal vessels on the unit GE Logiq 400 CL PRO Series. The velocity and indices
of peripheral blood resistance in the major renal artery (RA) and in intrarenal arteries were estimated.
In 26 patients the blood flow was studied again after intake of 50 mg captopril.
Results. Poor renal blood flow was registered in cortical parenchyma in 36% CGN patients (with
chronic renal failure in 75%). Multifactorial regression analysis has demonstrated that only blood creatinine
was independently related with slowing down of the blood flow at the level of RA and intrarenal
arteries. Morphological index of activity correlated with resistance indices while a high sclerosis
index correlated with blood flow slowing. Older patients had higher resistance indices. Captopril significantly
accelerated Mod flow and insignificantly changed indices of peripheral resistance including
those in CRF patients.
Conclusion. Poor blood flow in the cortical layer of renal parenchyma in CGN, according to USDG,
occurs rather frequently and was associated with CRF and older age of the patients. Blocking of reninangiotensin
system at the level of angiotensin II formation improves renal blood flow in most of the patients.
About the authors
S A Marlynov
M Yu Shvetsov
I M Kutyrina
N G Miroshnichenko
V V Kushnir
S V Petrov
T Ya Struchkova
B R Dzhanaliev
V A Varshavsky
E P Proskurneva
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