Канонический сигнальный путь Wnt/β-катенин: от истории открытия до клинического применения
- Авторы: Гребенникова TА1, Белая ЖЕ1, Рожинская ЛЯ1, Мельниченко ГА1
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Учреждения:
- Эндокринологический научный центр Минздрава России
- Выпуск: Том 88, № 10 (2016)
- Страницы: 74-81
- Раздел: Передовая статья
- Статья получена: 11.04.2020
- Статья опубликована: 15.10.2016
- URL: https://ter-arkhiv.ru/0040-3660/article/view/32648
- DOI: https://doi.org/10.17116/terarkh201688674-81
- ID: 32648
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Аннотация
Аннотация Сигнальный путь Wnt (СП-Wnt) — филогенетически древний механизм регуляции развития и поддержания гомеостаза тканей за счет контроля пролиферации, дифференциации, миграции и апоптоза клеток. Точность регуляции канонического сигнального пути Wnt/β-катенин (далее в тексте сигнальный путь Wnt — СП-Wnt) имеет решающее значение в эмбриогенезе и постнатальном развитии, а нарушение проведения сигналов на одном из его этапов приводит к различным заболеваниям, включая пороки развития органов, раковые заболевания, метаболические и нейродегенеративные расстройства. Обзор литературы посвящен обсуждению биологической роли канонического СП-Wnt в развитии скелета и ремоделировании костной ткани. Изменения в передаче сигнала Wnt, наблюдаемые при генетических мутациях, вызывают различные заболевания скелета человека. Понимание функциональных механизмов развития патологии костной ткани позволило открыть новые горизонты в лечении остеопороза за счет влияния на СП-Wnt. Наиболее перспективным в настоящее время является разработка антител к склеростину — ингибитору СП-Wnt. Статья обобщает исследования, посвященные каноническому СП-Wnt и разработке лекарственных препаратов для лечения остеопороза.
Ключевые слова
Об авторах
T А Гребенникова
Эндокринологический научный центр Минздрава РоссииМосква, Россия
Ж Е Белая
Эндокринологический научный центр Минздрава РоссииМосква, Россия
Л Я Рожинская
Эндокринологический научный центр Минздрава РоссииМосква, Россия
Г А Мельниченко
Эндокринологический научный центр Минздрава РоссииМосква, Россия
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