Анемический синдром при ревматоидном артрите: подходы к диагностике и возможности терапии
- Авторы: Гринштейн ЮИ1, Шабалин ВВ1, Кусаев ВВ1
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Учреждения:
- «Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава России
- Выпуск: Том 88, № 5 (2016)
- Страницы: 107-112
- Раздел: Передовая статья
- Статья получена: 10.04.2020
- Статья опубликована: 15.05.2016
- URL: https://ter-arkhiv.ru/0040-3660/article/view/32017
- ID: 32017
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Аннотация
Анемия хронического заболевания (АХЗ) — ведущая причина анемического синдрома у больных ревматоидным артритом (РА). Ключевым патогенетическим звеном АХЗ (часто именуемой анемией воспаления) представляется усиленная продукция гепсидина под влиянием главным образом избыточного уровня интерлейкина-6. Гепсидин, вызывая деградацию трансмембранного белка ферропортина, приводит к нарушению метаболизма железа. В обзоре по материалам последних публикаций представлены сведения о патогенезе АХЗ при РА, диагностике и дифференциальной диагностике АХЗ, особенно в случае ее сочетания с железодефицитной анемией, а также подходы к терапии этого сложного по механизму развития варианта анемического синдрома.
Ключевые слова
Об авторах
Ю И Гринштейн
«Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава РоссииКрасноярск, Россия
В В Шабалин
«Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава РоссииКрасноярск, Россия
В В Кусаев
«Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого» Минздрава РоссииКрасноярск, Россия
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