Evaluation of the efficacy and tolerance of ibandronic acid in patients with osteoarthrosis in the knee joints concurrent with osteoporosis: A pilot study


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AIM: To evaluate the efficacy and tolerance of ibandronic acid (bonviva) in patients with osteoporosis (OP) concurrent with osteoarthrosis (OA) in the knee joints (KJ)/MATERIAL AND METHODS: Twenty female outpatients aged 56 to 77 years with postmonopausal OP and primary KJ OA were examined. All the patients took bonviva in a dose of 150 mg monthly during a year/RESULTS: During the treatment, the patients showed a significant reduction in the values of all components of the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) (pain intensity from 51.7±11.6 to 34.6±20.7 mm, stiffness from 96.0±55.6 to 78.5±46.6 mm, and functional failure from 783.6±333.2 to 657.8±360.9 mm according to a visual analogue scale), the Oswestry disability index, as well as in the concentration of markers for bone resorption and cartilage degradation. The need for nonsteroidal anti-inflammatory drugs was stated to decrease/CONCLUSION: Bonviva therapy results in a significant reduction in pain, KJ stiffness, and locomotor functional failure in patients with gonoarthrosis.

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Оценка эффективности и переносимости ибандроновой кислоты у больных с сочетанием остеоартроза коленных суставов и остеопороза: пилотное исследование. - Резюме. Цель исследования. Оценка эффективности и переносимости препарата ибандроновой кислоты (бонвива) у больных с сочетанием остеопороза (ОП) и остеоартроза (ОА) коленных суставов (КС). Материалы и методы. Обследовали 20 амбулаторных пациентов (женщины в возрасте от 56 до 77 лет) с постменопаузальным ОП и первичным ОА КС. Все больные в течение года принимали препарат бонвива в дозе 150 мг в месяц. Результаты. На фоне лечения у больных отмечено достоверное снижение значений всех составляющих индекса WOMAC (боли с 51,7±11,6 до 34,6±20,7 мм, скованности с 96,0±55,6 до 78,5±46,6 мм и функциональной недостаточности с 783,6±333,2 до 657,8±360,9 мм по визуальной аналоговой шкале) и индекса Освестри, а также концентрации маркеров резорбции кости ткани и деградации хряща. Констатировано снижение потребности в нестероидных противовоспалитель­ных препаратах. Заключение. Терапия препаратом бонвива приводит к достоверному уменьшению боли и скованности в КС, а также функциональной недостаточности опорно-двигательного аппарата у больных гонартрозом.
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