Clinical and morphological features of lung injury long-term after SARS-CoV-2 recovery
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Clinical and morphological features of lung injury long-term after SARS-CoV-2 recovery |
| 2. | Creator | Author's name, affiliation, country | Gulsara E. Baimakanova; Loginov Moscow Clinical Scientific Center ; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Maria Samsonova; Loginov Moscow Clinical Scientific Center; Research Institute of Pulmonology ; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Andrey L. Chernyaev; Research Institute of Pulmonology; Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Andrey S. Kontorschikov; Petrovsky National Research Centre of Surgery ; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Andrey S. Belevskiy; Pirogov Russian National Research Medical University ; Russian Federation |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | SARS-CoV-2; interstitial pneumonia; pulmonary fibrosis |
| 4. | Description | Abstract | Aim. To study the clinical and histological profile of lung tissue in patients with persistent pulmonary disease, respiratory symptoms and CT findings after SARS-CoV-2 infection. Materials and methods. The study included 15 patients (7 females and 8 males) with a mean age of 57.7 years. All patients underwent laboratory tests, chest computed tomography, echocardiography, and pulmonary function tests. Pulmonary tissue and bronchoalveolar lavage samples were obtained by fibrobronchoscopy, transbronchial forceps (2 patients), and lung cryobiopsy (11 patients); open biopsy was performed in 2 patients. Cellular composition, herpesvirus DNA, SARS-CoV-2, Mycobacterium tuberculosis complex, galactomannan optical density index, and bacterial and fungal microflora growth were determined in bronchoalveolar lavage. SARS-CoV-2 was also identified in samples from the nasal mucosa, throat and feces using a polymerase chain reaction. Results. The results showed no true pulmonary fibrosis in patients recovered from SARS-CoV-2 infection with persistent respiratory symptoms, functional impairment, and CT findings after SARS-CoV-2 infection. The observed changes comply with the current and/or resolving infection and inflammatory process. Conclusion. Thus, no true pulmonary fibrosis was found in patients after SARS-CoV-2 infection with persistent respiratory symptoms, functional impairment, and CT findings. The observed changes comply with the current and/or resolving infection and inflammatory process. |
| 5. | Publisher | Organizing agency, location | LLC Obyedinennaya Redaktsiya |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 16.04.2024 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Research Article |
| 9. | Format | File format | XML(Rus), |
| 10. | Identifier | Uniform Resource Identifier | https://ter-arkhiv.ru/0040-3660/article/view/629970 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.26442/00403660.2024.03.202647 |
| 11. | Source | Title; vol., no. (year) | Terapevticheskii arkhiv; Vol 96, No 3 (2024): Issues of pulmonology |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files |
Fig. 1. Organizing focal pneumonia. Hematoxylin and eosin staining. (340KB) Fig. 2. Cellular type of nonspecific interstitial pneumonia. Hematoxylin and eosin staining. (359KB) Fig. 3. Fibrous type of nonspecific interstitial pneumonia. Hematoxylin and eosin staining. (310KB) Fig. 4. Fibrous type of nonspecific interstitial pneumonia: thickening of the interalveolar septum due to the proliferation of myofibroblasts and fibroblasts. Immunohistochemistry: a – SMA; b – vimentin. (433KB) Fig. 5. Focal intra-alveolar hemorrhage, edema. Hematoxylin and eosin staining. (360KB) Fig. 6. Focal peribronchial fibrosis, represented by fibroatelectasis with slit-like structures. Hematoxylin and eosin staining. (304KB) |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
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