Gene therapy of type 2 diabetes mellitus: state of art
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Gene therapy of type 2 diabetes mellitus: state of art |
| 2. | Creator | Author's name, affiliation, country | Yu S Stafeev; National Medical Research Centre for Cardiology of the Ministry of Health of the Russian Federation; M.V. Lomonosov Moscow State University |
| 2. | Creator | Author's name, affiliation, country | M Yu Menshikov; National Medical Research Centre for Cardiology of the Ministry of Health of the Russian Federation |
| 2. | Creator | Author's name, affiliation, country | Ye V Parfyonova; National Medical Research Centre for Cardiology of the Ministry of Health of the Russian Federation; M.V. Lomonosov Moscow State University |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | diabetes mellitus type 2; gene therapy; insulin resistance |
| 4. | Description | Abstract | Type 2 diabetes mellitus (T2DM) and other metabolic diseases are essential links in the structure of morbidity and mortality in the modern world. The accepted strategy for the correction of T2DM and insulin resistance is drug therapy aimed at delivering insulin from the outside, stimulating the secretion of own insulin and reducing the concentration of blood glucose. However, modern studies demonstrate a great potential for the use of gene therapy approaches for the correction of T2DM and insulin resistance. In the present review, the main variants of plasmid gene therapy of T2DM using the genes of adiponectin and type 1 glucagon-like peptide, as well as the main variants of viral gene therapy of T2DM using the genes of type 1 and leptin are considered. T2DM gene therapy is currently not ready to enter into routine clinical practice, but, subject to improvements in delivery systems, it can be a powerful link in combination therapy for diabetes. |
| 5. | Publisher | Organizing agency, location | LLC Obyedinennaya Redaktsiya |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 15.02.2019 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Review Article |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://ter-arkhiv.ru/0040-3660/article/view/32975 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.26442/00403660.2019.02.000042 |
| 11. | Source | Title; vol., no. (year) | Terapevticheskii arkhiv; Vol 91, No 2 (2019) |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2019 Consilium Medicum This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. |