Prognostic value of pathogenetic therapy-induced changes in NT-proBNP in patients with chronic heart failure
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Prognostic value of pathogenetic therapy-induced changes in NT-proBNP in patients with chronic heart failure |
| 2. | Creator | Author's name, affiliation, country | E M Mezhonov; |
| 2. | Creator | Author's name, affiliation, country | S V Shalaev; |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | NT-proBNP; left ventricular systolic dysfunction; prognosis; chronic heart failure; NT-proBNP |
| 4. | Description | Abstract | Aim. To study the prognostic value of therapy-induced changes in plasma NT-proBNP levels in patients with left ventricular (LV) systolic dysfunction. Subjects and methods. The study covered 84 patients aged 23 to 70 years (mean 54±8.1 years) with LV systolic dysfunction (an ejection fraction of <40%). Plasma NT-proBNP levels were determined in all the patients at baseline and 3 months later to evaluate the efficiency of therapy for heart failure (HF). The median follow-up was 18 months. The follow-up recorded the following outcomes (end points): death from decompensated HF and unplanned hospital admissions for progressive HF symptoms. Results. The baseline and therapy high plasma levels of NT-proBNP (more than 3000 pg/ml) were associated with worsening prognosis. The therapy-induced decrease in NT-proBNP levels was associated with more favorable prognosis. Conclusion. Repeat dynamic determination of plasma NT-proBNP levels allows identification of patients at increased risk of poor outcomes for a more intensive observation and more aggressive pathogenetic therapy. |
| 5. | Publisher | Organizing agency, location | LLC Obyedinennaya Redaktsiya |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 15.09.2012 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Research Article |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://ter-arkhiv.ru/0040-3660/article/view/31122 |
| 11. | Source | Title; vol., no. (year) | Terapevticheskii arkhiv; Vol 84, No 9 (2012) |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2012 Consilium Medicum This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. |