Results of hemopoietic cell transplantation in the first complete remission in children with acute myeloid leukemia from an intermediate risk group
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| 1. | Title | Title of document | Results of hemopoietic cell transplantation in the first complete remission in children with acute myeloid leukemia from an intermediate risk group |
| 2. | Creator | Author's name, affiliation, country | Z M Dyshlevaya; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | E V Skorobogatova; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | M A Maschan; Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation |
| 2. | Creator | Author's name, affiliation, country | I P Shipitsyna; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | Yu V Skvortsova; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | P E Trakhtman; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | D N Balashov; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | Yu V Pashko; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | E E Kurnikova; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | E V Suntsova; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | O V Goronkova; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | G G Solopova; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | D D Baidildina; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | I I Kalinina; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | L A Khachatryan; Russian Children's Hospital, Moscow |
| 2. | Creator | Author's name, affiliation, country | M M Shneider; Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation |
| 2. | Creator | Author's name, affiliation, country | A A Maschan; Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | acute myeloid leukemia; children; hemopoietic cell transplantations; treatment; efficiency; survival; melphalan |
| 4. | Description | Abstract | Aim. To analyze the results of allogeneic and autologous hemopoietic cell transplantations (allo- and auto-HCT) in children with acute myeloid leukemia (AML) from an intermediate risk group, most of which were performed using lower-intensity conditioning modes. Subjects and methods. The study enrolled 36 children from an intermediate risk group, who had undergone auto-HCT (n = 22) or allo-HCT (n = 14) in December 1994 to December 2008. The patients' age was 0.7 to 16.6 years (median 12.8 years). Chemotherapeutic conditioning regimens were applied to all the patients. Melphalan was a basic myeloablative agent in 83.3% of cases. Results. With a median follow-up of 4.6 years (1.1-13.8 years), three-year relapse-free survival (RFS) was 80.4%; overall survival (OS) was 65.6%. Recurrences were documented only in 6 (16.6%) patients from the auto-HCT. Transplantation-associated mortality (TAM) was 13.8% (five patients died). After allo-HCT versus auto-HCT, RFS, OS, and TAM were 100 and 68.7% (p = 0.03), 93.2 and 55.5% (p = 0.02), and 7.1 and 18.2%, respectively. Acute and chronic graft-versus-host reactions developed in 57.1 and 23.1%, respectively. Conclusion. Transplantation of allogeneic hemopoietic cells from a compatible related donor in the intermediate risk group children with AML, by using melphalan-based conditioning regimen, demonstrates a high survival rate with the minimum toxicity. |
| 5. | Publisher | Organizing agency, location | LLC Obyedinennaya Redaktsiya |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 15.07.2010 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://ter-arkhiv.ru/0040-3660/article/view/30616 |
| 11. | Source | Title; vol., no. (year) | Terapevticheskii arkhiv; Vol 82, No 7 (2010) |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2010 Consilium Medicum This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. |