<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">82981</article-id><article-id pub-id-type="doi">10.26442/00403660.2021.09.201023</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Influenza vaccination and prognosis for patients with high cardiovascular risk</article-title><trans-title-group xml:lang="ru"><trans-title>Вакцинация против гриппа и прогноз пациентов с высоким сердечно-сосудистым риском</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9240-9513</contrib-id><name-alternatives><name xml:lang="en"><surname>Dmitrieva</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Дмитриева</surname><given-names>Ольга Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>клин. ординатор каф. факультетской терапии №1 лечебного фак-та</p></bio><email>olga.dm.ru@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5820-1759</contrib-id><name-alternatives><name xml:lang="en"><surname>Mironova</surname><given-names>Olga Iu.</given-names></name><name xml:lang="ru"><surname>Миронова</surname><given-names>Ольга Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. факультетской терапии №1 лечебного фак-та</p></bio><email>olga.dm.ru@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2682-4417</contrib-id><name-alternatives><name xml:lang="en"><surname>Fomin</surname><given-names>Victor V.</given-names></name><name xml:lang="ru"><surname>Фомин</surname><given-names>Виктор Викторович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>чл.-кор. РАН, д-р мед. наук, проф., проректор по клинической работе и ДПО, зав. каф. факультетской терапии №1 лечебного фак-та</p></bio><email>olga.dm.ru@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2021</year></pub-date><volume>93</volume><issue>9</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>1100</fpage><lpage>1105</lpage><history><date date-type="received" iso-8601-date="2021-10-10"><day>10</day><month>10</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-10-10"><day>10</day><month>10</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/82981">https://ter-arkhiv.ru/0040-3660/article/view/82981</self-uri><abstract xml:lang="en"><p>Cardiovascular and respiratory diseases have been one of the leading causes of mortality in the world for over 15 years. According to the results of various studies, a clear connection was revealed between the incidence of influenza and the decompensation of cardiovascular diseases, which leads to the development of acute coronary syndrome, acute heart failure and myocardial infarction. Also, the incidence of influenza is associated with an increase in the length of hospitalization, treatment costs and patient mortality. Influenza vaccination, especially in patients with high cardiovascular risk, is one of the most important secondary prevention measures. The article is dedicated to an overview of the problems of vaccination against influenza, the study of the prognosis of patients with high cardiovascular risk, as well as general points in the pathogenesis of influenza and cardiovascular diseases.</p></abstract><trans-abstract xml:lang="ru"><p>Сердечно-сосудистые и респираторные заболевания занимают одни из лидирующих позиций среди причин смертности населения в мире более 15 лет. По результатам разных исследований выявлена четкая взаимосвязь между заболеваемостью гриппом и декомпенсацией сердечно-сосудистых заболеваний, что ведет к развитию острого коронарного синдрома, острой сердечной недостаточности и инфаркта миокарда. Также заболеваемость гриппом связана с увеличением продолжительности госпитализации, расходов на лечение и смертности пациентов. Вакцинация против гриппа, особенно у пациентов с высоким сердечно-сосудистым риском, является одной из важнейших мер вторичной профилактики. Статья посвящена обзору проблем вакцинации против гриппа, изучению прогноза пациентов с высоким сердечно-сосудистым риском, а также общим моментам в патогенезе гриппа и сердечно-сосудистых заболеваний.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cardiovascular diseases</kwd><kwd>influenza</kwd><kwd>cardiovascular risk</kwd><kwd>acute coronary syndrome</kwd><kwd>myocardial infarction</kwd><kwd>influenza vaccination</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>грипп</kwd><kwd>сердечно-сосудистый риск</kwd><kwd>острый коронарный синдром</kwd><kwd>инфаркт миокарда</kwd><kwd>вакцинация против гриппа</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Warren-Gash C, Blackburn R, Whitaker H, et al. Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland. Eur Respir J. 2018;51(3):1701794. DOI:10.1183/13993003.01794-2017</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Graham-Rowe D. Epidemiology: Racing against the flu. Nature. 2011;480(7376):S2-3. DOI:10.1038/480S2a</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Vardeny O, Udell JA, Joseph J, et al. High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial. Am Heart J. 2018;202:97-103. DOI:10.1016/j.ahj.2018.05.007</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>For Europe WHORO. WHO Regional Office for Europe recommendations on influenza vaccination for the 2020/2021 season during the ongoing COVID-19 pandemic. World Health Organization. Regional Office for Europe; 2020.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Клинические рекомендации. Острый инфаркт миокарда с подъемом сегмента ST электрокардиограммы. 2020. Режим доступа: https://scardio.ru/content/Guidelines/2020/Clinic_rekom_OKS_sST.pdf. Ссылка активна на 24.08.2021 [Clinical guidelines. Acute myocardial infarction with ST segment elevation on electrocardiogram. 2020. Available at: https://scardio.ru/content/Guidelines/2020/Clinic_rekom_OKS_sST.pdf. Accessed: 24.08.2021 (in Russian)].</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Клинические рекомендации. Острый инфаркт миокарда без подъема сегмента ST электрокардиограммы. 2020. Режим доступа: https://scardio.ru/content/Guidelines/2020/Clinic_rekom_OKS_bST.pdf. Ссылка активна на 24.08.2021 [Clinical guidelines. Acute myocardial infarction without ST segment elevation on electrocardiogram. 2020. Available at: https://scardio.ru/content/Guidelines/2020/Clinic_rekom_OKS_bST.pdf. Accessed: 24.08.2021 (in Russian)].</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42(14):1289-367. DOI:10.1093/eurheartj/ehaa575</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ciszewski A. Cardioprotective effect of influenza and pneumococcal vaccination in patients with cardiovascular diseases. Vaccine. 2018;36:202-6. DOI:10.1016/j.vaccine.2017.11.078</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Muscente F, de Caterina R. Causal relationship between influenza infection and risk of acute myocardial infarction: pathophysiological hypothesis and clinical implications. Eur Heart J. 2020;22(Suppl. E): E68-72. DOI:10.1093/EURHEARTJ/SUAA064</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Luan YY, Yao YM. The clinical significance and potential role of C-reactive protein in chronic inflammatory and neurodegenerative diseases. Front Immunol. 2018;9:1-8. DOI:10.3389/fimmu.2018.01302</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Garraud O, Kehrel BE, Badimon L, et al. C-Reactive Protein in Atherothrombosis and Angiogenesis. Frontiers in Immunology. Frontiers Media S.A. 2018;9:430. DOI:10.3389/fimmu.2018.00430</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Tripathi B, Kumar V, Kalra A, et al. Influence of Influenza Infection on In-Hospital Acute Myocardial Infarction Outcomes. Am J Cardiol. 2020;130:7-14. DOI:10.1016/j.amjcard.2020.05.045</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Cardoso R, Rivera M, Czarny MJ, et al. In-Hospital Management and Outcomes of Patients With Acute Myocardial Infarction and Influenza. Am J Cardiol. 2020;125(6):840-4. DOI:10.1016/j.amjcard.2019.12.032</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Smeeth L, Thomas SL, Hall AJ, et al. Risk of Myocardial Infarction and Stroke after Acute Infection or Vaccination. N Engl J Med. 2004;351(25):2611-8. DOI:10.1056/nejmoa041747</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Gurfinkel EP, Leon De La Fuente R, Mendiz O, Mautner B. Flu vaccination in acute coronary syndromes and planned percutaneous coronary interventions (FLUVACS) Study: One-year follow-up. Eur Heart J. 2004;25(1):25-31. DOI:10.1016/j.ehj.2003.10.018</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Naghavi M, Barlas Z, Siadaty S, et al. Association of influenza vaccination and reduced risk of recurrent myocardial infarction. Circulation. 2000;102(25):3039-45. DOI:10.1161/01.CIR.102.25.3039</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Meyers DG, Beahm DD, Jurisich PD, et al. Influenza and pneumococcal vaccinations fail to prevent myocardial infarction. Heart Drug. 2004;4(2):96-100. DOI:10.1159/000077705</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Heffelfinger JD, Heckbert SR, Psaty BM, et al. Influenza vaccination and risk of incident myocardial infarction. Hum Vaccin. 2006;2(4):161-6. DOI:10.4161/hv.2.4.2943</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Puig-Barberà J, Díez-Domingo J, Varea ÁB, et al. Effectiveness of MF59TM-adjuvanted subunit influenza vaccine in preventing hospitalisations for cardiovascular disease, cerebrovascular disease and pneumonia in the elderly. Vaccine. 2007;25(42):7313-21. DOI:10.1016/j.vaccine.2007.08.039</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Siriwardena AN, Gwini SM, Coupland CAC. Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: Matched case – Control study. CMAJ. 2010;182(15):1617-23. DOI:10.1503/cmaj.091891</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Warren-Gash C, Geretti AM, Hamilton G, et al. Influenza-like illness in acute myocardial infarction patients during the winter wave of the influenza A H1N1 pandemic in London: A case-control study. BMJ Open. 2013;3(5):1-7. DOI:10.1136/bmjopen-2013-002604</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>MacIntyre CR, Heywood AE, Kovoor P, et al. Ischaemic heart disease, influenza and influenza vaccination: A prospective case control study. Heart. 2013;99(24):1843-8. DOI:10.1136/heartjnl-2013-304320</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Hsu SY, Chen FL, Liaw YP, et al. A matched influenza vaccine strain was effective in reducing the risk of acute myocardial infarction in elderly persons: A population-based study. Med (United States). 2016;95(10):1-6. DOI:10.1097/MD.0000000000002869</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Barnes M, Heywood AE, Mahimbo A, et al. Acute myocardial infarction and influenza: A meta-analysis of case-control studies. Heart. 2015;101(21):1738-47. DOI:10.1136/heartjnl-2015-307691</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Karaulov AV, Bykov AS, Volkova NV. Review of Grippol Family Vaccine Studies and Modern Adjuvant Development. Epidemiol Vaccinal Prev. 2019;18(4):101-19. DOI:10.31631/2073-3046-2019-18-4-101-119</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Wu HH, Chang YY, Kuo SC, Chen YT. Influenza vaccination and secondary prevention of cardiovascular disease among Taiwanese elders – A propensity score-matched follow-up study. PLoS One. 2019;14(7):e0219172. DOI:10.1371/journal.pone.0219172</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Brookhart MA, Patrick AR, Dormuth C, et al. Adherence to Lipid-lowering Therapy and the Use of Preventive Health Services: An Investigation of the Healthy User Effect. Am J Epidemiol. 2007;166(3):348-54. DOI:10.1093/aje/kwm070</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Shrank WH, Patrick AR, Brookhart MA. Healthy User and Related Biases in Observational Studies of Preventive Interventions: A Primer for Physicians. J Gen Intern Med. 2010;26(5):546-50. DOI:10.1007/s11606-010-1609-1</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Madjid M, Awan I, Ali M, et al. Influenza and atherosclerosis: Vaccination for cardiovascular disease prevention. Expert Opin Biol Ther. 2005;5(1):91-6. DOI:10.1517/14712598.5.1.91</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Shah AM, Pfeffer MA, Hartley LH, et al. Risk of all-cause mortality, recurrent myocardial infarction, and heart failure hospitalization associated with smoking status following myocardial infarction with left ventricular dysfunction. Am J Cardiol. 2010;106(7):911-6. DOI:10.1016/j.amjcard.2010.05.021</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Critchley JA, Capewell S. Smoking cessation for the secondary prevention of coronary heart disease. Cochrane Database Syst Rev. 2012;(2):1465-858. DOI:10.1002/14651858.CD003041.pub3</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet. 2010;376(9753):1670-81. DOI:10.1016/S0140-6736(10)61350-5</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Sheng X, Wei L, Murphy MJ, MacDonald TM. Statins and total (not LDL) cholesterol concentration and outcome of myocardial infarction: Results from a meta-analysis and an observational study. Eur J Clin Pharmacol. 2009;65(11):1071-80. DOI:10.1007/s00228-009-0720-x</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Ferrari R, Bertrand ME, Remme WJ, et al. Insight into ACE inhibition in the prevention of cardiac events in stable coronary artery disease: The EUROPA trial. Expert Rev Cardiovasc Ther. 2007;5(6):1037-46. DOI:10.1586/14779072.5.6.1037</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>England TN. Effect of Ramipril on Cardiovascular Events in High-Risk Patients. N Engl J Med. 2000;343(1):64-6. DOI:10.1056/nejm200007063430113</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>MacIntyre CR, Mahimbo A, Moa AM, Barnes M. Influenza vaccine as a coronary intervention for prevention of myocardial infarction. Heart. 2016;102(24):1953-6. DOI:10.1136/heartjnl-2016-309983</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Shalnova SA, Deev AD. Russian mortality trends in the early XXI century: Official statistics data. Cardiovasc Ther Prev. 2011;10(6):5-10. DOI:10.15829/1728-8800-2011-6-5-10</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Goldsteyn EM. Influenza-associated mortality for circulatory and respiratory causes during the 2013–2014 through the 2018–2019 influenza seasons in Russia. Int J Appl Fundam Res. 2019;12:9-16. DOI:10.17513/mjpfi.12945</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Vardeny O, Madjid M, Solomon SD. Applying the Lessons of Influenza to COVID-19 During a Time of Uncertainty. Circulation. 2020;141(21):1667-9. DOI:10.1161/CIRCULATIONAHA.120.046837</mixed-citation></ref></ref-list></back></article>
