Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya7631310.26442/00403660.2021.07.200929Research ArticleAllogeneic hematopoietic stem cell transplantation in patients with multiple myelomaFirsovaMaiia V.firs-maia@yandex.ruhttps://orcid.org/0000-0003-4142-171XMendeleevaLarisa P.firs-maia@yandex.ruhttps://orcid.org/0000-0002-4966-8146ParovichnikovaElena N.firs-maia@yandex.ruhttps://orcid.org/0000-0001-6177-3566SolovevMaksim V.firs-maia@yandex.ruhttps://orcid.org/0000-0002-7944-6202KuzminaLarisa A.firs-maia@yandex.ruhttps://orcid.org/0000-0001-6201-6276RisinskayaNatalia V.firs-maia@yandex.ruhttps://orcid.org/0000-0003-2957-1619AbramovaTatiana V.firs-maia@yandex.ruhttps://orcid.org/0000-0003-3163-4930GaltsevaIrina V.firs-maia@yandex.ruhttps://orcid.org/0000-0002-8490-6066SavchenkoValerii G.firs-maia@yandex.ruhttps://orcid.org/0000-0001-8188-5557National Research Center for Hematology1507202193777878420072021Copyright © 2021, Consilium Medicum2021<p><strong>Aim. </strong>To analyze the effectiveness of allogeneic hematopoietic stem cell transplantation (allo-HSCT) from a related HLA-identical donor in patients with multiple myeloma (MM).</p>
<p><strong>Materials and methods. </strong>From 2013 to 2018, the study included 8 patients (6 men, 2 women) aged from 27 to 55 years (median 39 years) with MM who underwent allo-HSCT from a related HLA-identical donor (7 patients after auto-HSCT, in 1 case without previous auto-transplantation). All patients required 2 or more lines of induction therapy, while the achieved antitumor effect was unstable. Before allo-HSCT, complete and very good partial remission was determined in isolated cases, in 4 patients the response was regarded as partial remission, stabilization in 1 observation, progression in 1 patient. All patients underwent reduced intensity conditioning (fludarabine 30 mg/m<sup>2</sup> 6 days + busulfan 4 mg/kg 2 days). Immunosuppressive therapy included the administration of antithymocyte globulin and post-transplant cyclophosphamide.</p>
<p><strong>Results. </strong>Severe acute GVHD (grade 34) was observed in 3 (37.5%) cases, which resulted in death in 1 case. A stable antitumor response was achieved in 5 (62.5%) patients, complete remission lasts for 2986 months after allo-HSCT. Specific therapy for these patients is not carried out. The 7-year progression-free survival rate was 75%, the 7-year overall survival rate was 84%, with a median follow-up of 65 months. The transplant-related mortality was 12.5%.</p>
<p><strong>Conclusion. </strong>Allo-HSCT is considered as an alternative method of therapy for young patients with aggressive MM. Allo-HSCT in MM in some cases leads to long-term immunological control of the tumor.</p>multiple myelomaallogeneic hematopoietic stem cell transplantationautologous hematopoietic stem cell transplantationreduced intensity conditioninggraft versus host diseaseмножественная миеломатрансплантация аллогенных гемопоэтических стволовых клетоктрансплантация аутологичных гемопоэтических стволовых клетокпредтрансплантационное кондиционирование в режиме пониженной интенсивностиреакция трансплантат против хозяина[Kumar SK, Dispenzieri A, Lacy MQ, et al. Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients. Leukemia. 2014;28(5):1122-8. DOI:10.1038/leu.2013.313][Dhakal B, Szabo A, Chhabra S, et al. 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