Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya7596610.26442/00403660.2021.06.200868Research ArticleRole of the intestinal MALT in pathogenesis of the IgA-nephropathyGuliaevSergei V.guldoc@mail.ruhttps://orcid.org/0000-0001-6138-4333StrizhakovLeonid A.guldoc@mail.ruhttps://orcid.org/0000-0002-2291-6453ChebotarevaNatalia V.guldoc@mail.ruhttps://orcid.org/0000-0003-2128-8560MoiseevSergei V.guldoc@mail.ruhttps://orcid.org/0000-0002-7232-4640Sechenov First Moscow State Medical University (Sechenov University)Lomonosov Moscow State University150620219367247281007202110072021Copyright © 2021, Consilium Medicum2021<p>Modern view on pathogenesis of immunoglobulin (Ig)A-nephropathy and possible relation to intestinal MALT-system activity is presented in the article. Aberrant glycosylation of IgA and increased association of IgA-nephropathy with intestinal diseases or abnormal intestinal permeability are discussed in details. Based on supposed entero-renal pathogenesis of the disease future treatment modalities are considered. Relevant worlds literature is cited.</p>immunoglobulin A-nephropathyimmunoglobulin Aаberrant glycosylation of immunoglobulin Aintestinal permeabilityMALTиммуноглобулин A-нефропатияиммуноглобулин Aдефектное гликозилирование иммуноглобулина Aкишечная проницаемостьMALT[Berger J, Hinglais N. Les dépôts intercapillaires d'IgA-IgG. J Urol Nephrol. 1968;74:694-95][Добронравов В.А., Мужецкая Т.О., Лин Д.И., Кочоян З.Ш. Иммуноглобулин А-нефропатия в российской популяции: клинико-морфологическая презентация и отдаленный прогноз. Нефрология (Санкт-Петербург). 2019;23(6):45-60 [Dobronravov VA, Muzhetskaya TO, Lin DI, Kochoyan ZS. Immunoglobulin A-nephropathy in Russian population: clinical and morphological presentation and long-term prognosis. Nephrology (Saint-Petersburg). 2019;23(6):45-60 (in Russian)]. DOI:10.36485/1561-6274-2019-236-45-60][Zhang C, Zeng X, Li Z, et al. 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