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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">703865</article-id><article-id pub-id-type="doi">10.26442/00403660.2026.07.203674</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>History of medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>История медицины</subject></subj-group><subj-group subj-group-type="article-type"><subject>Miscellaneous</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The evolution of the treadmill test in cardiology: from clinical observation to a global standard of functional diagnostics</article-title><trans-title-group xml:lang="ru"><trans-title>Эволюция тредмил-теста в кардиологии: от клинического наблюдения к глобальному стандарту функциональной диагностики</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5820-1759</contrib-id><name-alternatives><name xml:lang="en"><surname>Trushina</surname><given-names>Olga Iu.</given-names></name><name xml:lang="ru"><surname>Трушина</surname><given-names>Ольга Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>проф. РАН, д-р мед. наук, проф. каф. факультетской терапии №1 Института клинической медицины им. Н.В. Склифосовского</p></bio><email>e.okisheva@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2977-7203</contrib-id><name-alternatives><name xml:lang="en"><surname>Okisheva</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Окишева</surname><given-names>Елена Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. факультетской терапии №1 Института клинической медицины им. Н.В. Склифосовского</p></bio><email>e.okisheva@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-07-31" publication-format="electronic"><day>31</day><month>07</month><year>2026</year></pub-date><volume>98</volume><issue>7</issue><issue-title xml:lang="en">Vario (various)</issue-title><issue-title xml:lang="ru">Vario (разное)</issue-title><fpage>425</fpage><lpage>428</lpage><history><date date-type="received" iso-8601-date="2026-03-06"><day>06</day><month>03</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-03-28"><day>28</day><month>03</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/703865">https://ter-arkhiv.ru/0040-3660/article/view/703865</self-uri><abstract xml:lang="en"><p>The article describes the history of the development and implementation of stress tests in cardiology for the diagnosis of coronary heart disease, with a particular attention to the creation, implementation and development of the treadmill test.</p></abstract><trans-abstract xml:lang="ru"><p>В статье описана история разработки и внедрения в медицинскую практику нагрузочных тестов в кардиологии для диагностики ишемической болезни сердца, с отдельным акцентом на создание, разработку и развитие тредмил-теста.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cardiology</kwd><kwd>stress tests</kwd><kwd>treadmill test</kwd><kwd>coronary heart disease</kwd><kwd>history of medicine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кардиология</kwd><kwd>нагрузочные тесты</kwd><kwd>тредмил-тест</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>история медицины</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Gunga HC, Kirsch KA. Nathan Zuntz (1847–1920) – a German pioneer in high altitude physiology and aviation medicine, Part II: Scientific work. Aviat Space Environ Med. 1995;66(2):172-6.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Bruce RA, Blackmon JR, Jones JW, Strait G. Exercising testing in adult normal subjects and cardiac patients. 1963. Ann Noninvasive Electrocardiol. 2004;9(3):291-303. DOI:10.1111/j.1542-474X.2004.93003.x</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Master AM, Pordy L, Chesky K. Two-step exercise electrocardiogram; follow-up investigation in patients with chest pain and normal resting electrocardiogram. J Am Med Assoc. 1953;151(6):458-62.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Bruce RA, Lovejoy FW Jr, Yu PN, McDowell ME. Evaluation and significance of physical fitness for moderate work; a study of patients with cardiovascular or pulmonary diseases. AMA Arch Ind Hyg Occup Med. 1951;4(3):236-50.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Bruce RA, Merendino KA, Pampush JJ, et al. Functional evaluation of mitral valvulotomy; superiority of the treadmill exercise tolerance test to clinical and resting hemodynamic evaluations in selecting patients. Am J Med. 1956;20(5):745-55. DOI:10.1016/0002-9343(56)90156-5</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Truett JT, Benson H, Balke B. On the practicability of submaximal exercise testing. J Chronic Dis. 1966;19(6):711-5. DOI:10.1016/0021-9681(66)90069-5</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Bruce RA, Blackmon JR, Jones JW, Strait G. Exercising testing in adult normal subjects and cardiac patients. Pediatrics. 1963;32(4):742-56. DOI:10.1542/peds.32.4.742</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Nagle FJ, Balke B, Naughton JP. Gradational step tests for assessing work capacity. J Appl Physiol. 1965;20(4):745-8. DOI:10.1152/jappl.1965.20.4.745</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hollmann W, Prinz JP. Ergospirometry and its history. Sports Med. 1997;23(2):93-105. DOI:10.2165/00007256-199723020-00003</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Воронина В.П., Киселева Н.В., Марцевич С.Ю. Пробы с дозированной физической нагрузкой в кардиологии: прошлое, настоящее и будущее. Часть II. Кардиоваскулярная терапия и профилактика. 2015;14(3):82-8 [Voronina VP, Kiseleva NV, Martsevich SYu. Exercise tests in cardiology: past, present and future. Part II. Cardiovascular Therapy and Prevention. 2015;14(3):82-8 (in Russian)]. DOI:10.15829/1728-8800-2015-3-82-88</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Мухарлямов Н.М., Беленков Ю.Н. Применение эхокардиографии в диагностике заболеваний сердечно-сосудистой системы. Терапевтический архив. 1974;3:3 [Mukharlyamov NM, Belenkov YuN. Use of echocardiography in diagnostics of cardiovascular diseases. Terapevticheskii Arkhiv (Ter. Arkh.). 1974;3:3 (in Russian)].</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Бородулин В.И., Банзелюк Е.Н., Тополянский А.В. К истории становления кардиологии в СССР: кого называть ее основоположниками? Терапевтический архив. 2022;94(7):927-30 [Borodulin VI, Banzelyuk EN, Topolyanskiy AV. On the formation of cardiology in the USSR: who should be called its founders? Terapevticheskii Arkhiv (Ter. Arkh.). 2022;94(7):927-30 (in Russian)]. DOI:10.26442/00403660.2022.07.201739</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Окишева Е.А., Пятигорец Е.С., Окишев Д.Н., Трушина О.Ю. Лечение желудочковых аритмий при инфаркте миокарда: история вопроса. Терапевтический архив. 2025;97(9):814-8 [Okisheva EA, Pyatigorets ES, Okishev DN, Trushina OI. Treatment of ventricular arrhythmias in patients with myocardial infarction: timeline. Terapevticheskii Arkhiv (Ter. Arkh.). 2025;97(9):814-8 (in Russian)]. DOI:10.26442/00403660.2025.09.203348</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Миронова О.Ю., Исайкина М.А., Исаев Г.О., и др. Ультразвуковые исследования с контрастированием: история, применение в практике и перспективы. Терапевтический архив. 2023;95(4):360-4 [Mironova OI, Isaikina MA, Isaev GO, et al. Contrast-enhanced ultrasound: history, application and perspectives. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(4):360-4 (in Russian)]. DOI:10.26442/00403660.2023.04.202157</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Миронова О.Ю., Исаев Г.О., Бердышева М.В., и др. Современные методики оценки физиологической значимости стенозирующих поражений коронарных артерий. Терапевтический архив. 2023;95(4):341-6 [Mironova OIu, Isaev GO, Berdysheva MV, et al. Modern methods of assessment of physiological significance of coronary lesions: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(4):341-6 (in Russian)]. DOI:10.26442/00403660.2023.04.202169</mixed-citation></ref></ref-list></back></article>
