<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">703675</article-id><article-id pub-id-type="doi">10.26442/00403660.2026.05.203676</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The problem of osteoarthritis in patients with atopy</article-title><trans-title-group xml:lang="ru"><trans-title>Проблема остеоартрита у пациентов с атопией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2641-9785</contrib-id><name-alternatives><name xml:lang="en"><surname>Beketova</surname><given-names>Tatiana V.</given-names></name><name xml:lang="ru"><surname>Бекетова</surname><given-names>Татьяна Валентиновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, вед. науч. сотр., зав. отд-нием ревматологии с нефрологическими койками и кабинетом терапии генно-инженерными биологическими препаратами</p></bio><email>doc@tvbek.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1598-8360</contrib-id><name-alternatives><name xml:lang="en"><surname>Nasonov</surname><given-names>Evgeny L.</given-names></name><name xml:lang="ru"><surname>Насонов</surname><given-names>Евгений Львович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>акад. РАН, д-р мед. наук, проф., науч. рук.</p></bio><email>doc@tvbek.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Nasonova Research Institute of Rheumatology</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой» Минобрнауки России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central Clinical Hospital with Polyclinic</institution></aff><aff><institution xml:lang="ru">ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента РФ</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Moscow Polytechnic University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Московский политехнический университет» Минобрнауки России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-06-13" publication-format="electronic"><day>13</day><month>06</month><year>2026</year></pub-date><volume>98</volume><issue>5</issue><issue-title xml:lang="en">Issues of rheumatology</issue-title><issue-title xml:lang="ru">Вопросы ревматологии</issue-title><fpage>270</fpage><lpage>274</lpage><history><date date-type="received" iso-8601-date="2026-03-03"><day>03</day><month>03</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-04-16"><day>16</day><month>04</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/703675">https://ter-arkhiv.ru/0040-3660/article/view/703675</self-uri><abstract xml:lang="en"><p>The problem of osteoarthritis (OA) in patients with atopy (bronchial asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis) discussed. In patients with atopy, the risk of OA is significantly higher (36–58%) than in the general population. Possible mechanisms of OA in atopy are considered. Further research may help decipher the pathogenesis of OA and improve pharmacotherapy.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждается концепция взаимосвязи остеоартрита (ОА) и атопических заболеваний (бронхиальной астмы, атопического дерматита, аллергического ринита, аллергического конъюнктивита), при которых риск ОА значительно выше (на 36–58%), чем в общей популяции. Рассматривается возможная общность механизмов ОА и атопии, углубленное изучение которых может способствовать уточнению патогенеза ОА и совершенствованию фармакотерапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>atopy</kwd><kwd>bronchial asthma</kwd><kwd>atopic dermatitis</kwd><kwd>allergic rhinitis</kwd><kwd>allergic conjunctivitis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>атопия</kwd><kwd>бронхиальная астма</kwd><kwd>атопический дерматит</kwd><kwd>аллергический ринит</kwd><kwd>аллергический конъюнктивит</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Swain S, Sarmanova A, Coupland C, et al. Comorbidities in Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies. Arthritis Care Res (Hoboken). 2020;72(7):991-1000. DOI:10.1002/acr.24008</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Courties A, Kouki I, Soliman N, et al. Osteoarthritis year in review 2024: Epidemiology and therapy. Osteoarthritis Cartilage. 2024;32(11): 1397-404. DOI:10.1016/j.joca.2024.07.014</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Алексеева Л.И., Раскина Т.А., Таскина Е.А., и др. Мультиморбидность и плейотропные эффекты базисных препаратов, применяемых для лечения остеоартрита. Научно-практическая ревматология. 2025;63(4):331-7 [Alekseeva LI, Raskina TA, Taskina EA, et al. Multimorbidity and pleiotropic effects of basic drugs used for the treatment of osteoarthritis. Rheumatology Science and Practice. 2025;63(4): 331-7 (in Russian)]. DOI:10.47360/1995-4484-2025-331-337</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Трошина Е.А., Паневин Т.С., Брискман Т.Д. Роль ожирения в развитии и прогрессировании остеоартрита: влияние медикаментозных и хирургических методов лечения ожирения на течение воспалительных заболеваний суставов. Терапевтический архив. 2025;97(5):449-54 [Troshina EA, Panevin TS, Briskman TD. The role of obesity in the development and progression of osteoarthritis: the influence of medical and surgical therapies for obesity on the course of inflammatory arthritis: A review. Terapevticheskii Arkhiv (Ter. Arkh.). 2025;97(5):449-54 (in Russian)]. DOI:10.26442/00403660.2025.05.203230</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Wang Q, Lepus CM, Raghu H, et al. IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis. Elife. 2019;8:e39905. DOI:10.7554/eLife.39905</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Baker MC, Sheth K, Lu R, et al. Increased risk of osteoarthritis in patients with atopic disease. Ann Rheum Dis. 2023;82(6):866-72. DOI:10.1136/ard-2022-223640</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Li YS, Luo W, Zhu SA, Lei GH. T Cells in Osteoarthritis: Alterations and Beyond. Front Immunol. 2017;8:356. DOI:10.3389/fimmu.2017.00356</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Rezuș E, Cardoneanu A, Burlui A, et al. The Link Between Inflammaging and Degenerative Joint Diseases. Int J Mol Sci. 2019;20(3):614. DOI:10.3390/ijms20030614</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Defois A, Bon N, Charpentier A, et al. Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF. Cell Commun Signal. 2023;21(1):137. DOI:10.1186/s12964-023-01150-z</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Wu Z, Luo X, Dou P, et al. Asthma, social isolation and loneliness, and risk of incident osteoarthritis. Arthritis Res Ther. 2025;27(1):29. DOI:10.1186/s13075-025-03496-w</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Park D, Choi YH, Han K, et al. Risk of knee osteoarthritis in patients with multiple atopic conditions: a nationwide study. Sci Rep. 2025;15(1):15293. DOI:10.1038/s41598-025-92247-7</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Wang H, Chen M, Wang T, et al. Atopic dermatitis and risk of autoimmune diseases: a systematic review and meta-analysis. Front Immunol. 2025;16:1539997. DOI:10.3389/fimmu.2025.1539997</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Wu LC, Hwang CY, Chung PI, et al. Autoimmune disease comorbidities in patients with atopic dermatitis: a nationwide case-control study in Taiwan. Pediatr Allergy Immunol. 2014;25(6):586-92. DOI:10.1111/pai.12274</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Lin CH, Lin CL, Shen TC, Wei CC. Epidemiology and risk of juvenile idiopathic arthritis among children with allergic diseases: a nationwide population-based study. Pediatr Rheumatol Online J. 2016;14(1):15. DOI:10.1186/s12969-016-0074-8</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lai NS, Tsai TY, Koo M, Lu MC. Association of rheumatoid arthritis with allergic diseases: A nationwide population-based cohort study. Allergy Asthma Proc. 2015;36(5):99-103. DOI:10.2500/aap.2015.36.3871</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Takanashi S, Akiyama M, Furuhashi K, et al. Distinct impact of malignancy and allergy on the clinical and immunological features of IgG4-related disease. Clin Exp Rheumatol. 2023;41(9):1754-61. DOI:10.55563/clinexprheumatol/7g2na0</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Akiyama M, Alshehri W, Ishigaki S, et al. The immunological pathogenesis of IgG4-related disease categorized by clinical characteristics. Immunol Med. 2025;48(1):11-23. DOI:10.1080/25785826.2024.2407224</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Vaseghi-Shanjani M, Samra S, Yousefi P, et al. Primary atopic disorders: inborn errors of immunity causing severe allergic disease. Curr Opin Immunol. 2025;94:102538. DOI:10.1016/j.coi.2025.102538</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Magnusson K, Turkiewicz A, Rydén M, Englund M. Genetic Influence on Osteoarthritis Versus Other Rheumatic Diseases. Arthritis Rheumatol. 2024;76(2):206-15. DOI:10.1002/art.42696</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Weldingh E, Johnsen MB, Hagen KB, et al. The Maternal and Paternal Effects on Clinically and Surgically Defined Osteoarthritis. Arthritis Rheumatol. 2019;71(11):1844-8. DOI:10.1002/art.41023</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Spector TD, MacGregor AJ. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage. 2004;12(Suppl. A):S39-44. DOI:10.1016/j.joca.2003.09.005</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Anker-Hansen C, Pirouzifard M, Sundquist J, et al. Familial risks of five types of osteoarthritis in first-, second- and third-degree relatives – A nationwide Swedish family study. Osteoarthr Cartil Open. 2025;7(3):100637. DOI:10.1016/j.ocarto.2025.100637</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Forster T, Chapman K, Loughlin J. Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis. Hum Genet. 2004;114(4):391-5. DOI:10.1007/s00439-004-1083-0</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Vargiolu M, Silvestri T, Bonora E, et al. Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis. Osteoarthritis Cartilage. 2010;18(6):810-6. DOI:10.1016/j.joca.2010.02.005</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Yigit S, Inanir A, Tekcan A, et al. Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis. Gene. 2014;537(1):6-9. DOI:10.1016/j.gene.2013.12.060</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Kim S. Relationship between Osteoarthritis and Atopic Dermatitis Based on the 3rd-8th Korea National Health and Nutrition Examination Survey. Korean J Geriatr Gerontol. 2024;25(1):49-59. DOI:10.15656/kjgg.2024.25.1.49</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Di J, Song L, Liu Y, et al. Eosinophil-to-Lymphocyte Ratio and Eosinophil Count as New Predictive Markers for Osteoarthritis. J Pain Res. 2024;17:3803-15. DOI:10.2147/JPR.S480925</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Montelukast for the treatment of erosive hand osteoarthritis. WIPO. Publication Number WO/2020/109230. Available at: https://patentscope.wipo.int/search/en/WO2020109230. Accessed: 20.02.2026.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Ponce L, Arjona M, Blanco G, et al. The effect of montelukast in a model of gouty arthritis induced by sodium monourate crystals. Invest Clin. 2011;52(1):15-22.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Dong H, Liu F, Ma F, et al. Montelukast inhibits inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes. Int Immunopharmacol. 2018;61:215-21. DOI:10.1016/j.intimp.2018.04.042</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Bihlet A, Miller C, Byrjalsen I, et al. Antihistamine Use and Structural Progression of Knee OA: A Post-Hoc Analysis of Two Phase 3 Clinical Trials [abstract]. Arthritis Rheumatol. 2022;74(Suppl. 9). Available at: https://acrabstracts.org/abstract/antihistamine-use-and-structural-progression-of-knee-oa-a-post-hoc-analysis-of-two-phase-3-clinical-trials/. Accessed: 20.02.2026.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Zúñiga VA, Bazan-Perkins B. The impact of vitamin D on atopic disorders: assessing evidence for a causal relationship. Front Nutr. 2025;12:1584818. DOI:10.3389/fnut.2025.1584818</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Кашеварова Н.Г., Алексеева Л.И., Таскина Е.А., и др. Взаимосвязь витамина D и остеоартрита. Терапевтический архив. 2025;97(5):434-42 [Kashevarova NG, Alekseeva LI, Taskina EA, et al. Relationship between vitamin D and osteoarthritis. Terapevticheskii Arkhiv (Ter. Arkh.). 2025;97(5):434-42 (in Russian)]. DOI:10.26442/00403660.2025.05.203228</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Jay R, Rodger J, Zirwas M. Review of dupilumab-associated inflammatory arthritis: An approach to clinical analysis and management. JAAD Case Rep. 2022;21:14-8. DOI:10.1016/j.jdcr.2021.12.011</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>See Tow HX, Yew YW. Joint Pain and Inflammatory Arthropathy after Dupilumab Use in Atopic Dermatitis: A Systematic Review and Meta-Analysis. Dermatitis. 2026;37(2):205-23. DOI:10.1089/derm.2025.0038</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Hanania NA, Niven R, Chanez P, et al. Long-term effectiveness and safety of omalizumab in pediatric and adult patients with moderate-to-severe inadequately controlled allergic asthma. World Allergy Organ J. 2022;15(10):100695. DOI:10.1016/j.waojou.2022.100695</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Dupin C, Valéry S, Guilleminault L, et al. Articular manifestations related to anti-interleukin-5 therapies in severe asthma: a case series. ERJ Open Res. 2024;10(1):00935-2023. DOI:10.1183/23120541.00935-2023</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Andreev D, Liu M, Kachler K, et al. Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis. Ann Rheum Dis. 2021;80(4):451-68. DOI:10.1136/annrheumdis-2020-218902</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Qin Y, Jin HZ, Li YJ, Chen Z. Emerging Role of Eosinophils in Resolution of Arthritis. Front Immunol. 2021;12:764825. DOI:10.3389/fimmu.2021.764825</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Kamata M, Tada Y. Optimal Use of Jak Inhibitors and Biologics for Atopic Dermatitis on the Basis of the Current Evidence. JID Innov. 2023;3(3):100195. DOI:10.1016/j.xjidi.2023.100195</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Georas SN, Donohue P, Connolly M, Wechsler ME. JAK inhibitors for asthma. J Allergy Clin Immunol. 2021;148(4):953-63. DOI:10.1016/j.jaci.2021.08.013</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Chiu YS, Bamodu OA, Fong IH, et al. The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p. Bone. 2021;151:116024. DOI:10.1016/j.bone.2021.116024</mixed-citation></ref></ref-list></back></article>
