Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya67790910.26442/00403660.2025.08.203345ReviewsОбзорыReview ArticleFixed-dose combinations of hypoglycemic drugs: potential of alogliptin/pioglitazone in type 2 diabetes mellitus: a reviewФиксированные комбинации гипогликемических препаратов: возможности алоглиптина/пиоглитазона при сахарном диабете 2-го типаhttps://orcid.org/0000-0001-7729-2169ButranovaOlga I.БутрановаОльга Игоревна
Russian Federation

канд. мед. наук, доц. каф. общей и клинической фармакологии Медицинского института

butranova-oi@rudn.ruhttps://orcid.org/0000-0002-6348-6867ZyryanovSergey K.ЗыряновСергей Кенсаринович
Russian Federation

д-р мед. наук, проф., зав. каф. общей и клинической фармакологии; зам. глав. врача

butranova-oi@rudn.ruhttps://orcid.org/0009-0002-1474-5014MelnikovaAnna R.МельниковаАнна Романовна
Russian Federation

студентка VI курса Медицинского института

butranova-oi@rudn.ruhttps://orcid.org/0009-0000-1961-609XMatsepuroAnastasia E.МацепуроАнастасия Евгеньевна
Russian Federation

студентка VI курса Медицинского института

butranova-oi@rudn.ruPatrice Lumumba Peoples' Friendship University of RussiaРоссийский университет дружбы народов им. Патриса ЛумумбыCity Clinical Hospital No. 24Городская клиническая больница №2428082025978Treatment issuesВопросы лечения7357493103202526082025Copyright ©; 2025, Consilium MedicumCopyright ©; 2025, ООО "Консилиум Медикум"2025Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/677909

Type 2 diabetes mellitus is one of the most common chronic diseases, which is a risk factor for a wide range of complications. The introduction of an approach consisting of early administration of combination hypoglycemic therapy into clinical practice makes it relevant to study available fixed-dose combinations of hypoglycemic drugs. Alogliptin and pioglitazone are of interest in terms of their complex effect on the patient's organism. The purpose of this review is to assess the advantages of the combination of alogliptin and pioglitazone based on an analysis of published data on the pharmacodynamics, pharmacokinetics, efficacy and safety of these drugs.

Сахарный диабет 2-го типа – одно из наиболее распространенных хронических заболеваний, являющихся фактором риска возникновения широкого круга осложнений. Внедрение в клиническую практику подхода, состоящего в раннем назначении комбинированной сахароснижающей терапии, делает актуальным изучение доступных фиксированных комбинаций гипогликемических препаратов. Алоглиптин и пиоглитазон представляют интерес с точки зрения комплексного воздействия на организм пациента при их совместном использовании. Цель настоящего обзора – оценка преимуществ комбинации алоглиптина и пиоглитазона на основе анализа опубликованных данных фармакодинамики, фармакокинетики, эффективности и безопасности указанных препаратов.

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