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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">643534</article-id><article-id pub-id-type="doi">10.26442/00403660.2025.11.203450</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические наблюдения</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A family imported case of dengue fever. Case report</article-title><trans-title-group xml:lang="ru"><trans-title>Семейный завозной случай лихорадки денге. Клиническое наблюдение</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9151-604X</contrib-id><name-alternatives><name xml:lang="en"><surname>Bondarenko</surname><given-names>Alla L.</given-names></name><name xml:lang="ru"><surname>Бондаренко</surname><given-names>Алла Львовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. инфекционных болезней</p></bio><email>kf14@kirovgma.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-9076-2434</contrib-id><name-alternatives><name xml:lang="en"><surname>Kontyakova</surname><given-names>Ekaterina L.</given-names></name><name xml:lang="ru"><surname>Контякова</surname><given-names>Екатерина Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, доц., врач-инфекционист</p></bio><email>kf14@kirovgma.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kirov State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Кировский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Infectious Diseases Clinical Hospital</institution></aff><aff><institution xml:lang="ru">КОГБУЗ «Инфекционная клиническая больница»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-12-20" publication-format="electronic"><day>20</day><month>12</month><year>2025</year></pub-date><volume>97</volume><issue>11</issue><issue-title xml:lang="en">Infectious diseases</issue-title><issue-title xml:lang="ru">Инфекционные болезни</issue-title><fpage>940</fpage><lpage>944</lpage><history><date date-type="received" iso-8601-date="2024-12-28"><day>28</day><month>12</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2025-09-22"><day>22</day><month>09</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/643534">https://ter-arkhiv.ru/0040-3660/article/view/643534</self-uri><abstract xml:lang="en"><p>Dengue fever is the most common zoonotic infection with a transmissible mechanism of virus transmission in tropical and subtropical countries. In the first two decades of the 21st century, a significant increase in dengue fever cases was registered in more than 120 countries worldwide. The article presents a family imported case of dengue fever in a 34-year-old man and a 35-year-old woman who fell ill within 3 days after returning from Thailand (Phuket Island). In both cases, there was an acute onset of the disease with an increase in body temperature to (39–40°С), severe weakness, severe muscle and joint pain, severe headache, and loose stools once or twice. They were treated independently for acute respiratory infections. They sought medical help on the 4th and 5th days of their illness and were admitted to an infectious diseases hospital. The disease was accompanied by the development of posterior cervical and submandibular lymphadenitis, hepatomegaly, an uncommon spotty-papular rash on the skin of the trunk and arms, single point hemorrhages, severe thrombocytopenia and leukopenia. The woman was diagnosed with posterior cervical and submandibular lymphadenitis, and hepatosplenomegaly. On the 6th day of the disease, the woman was radiographically diagnosed with peribronchial edema of the interstitium. On the 7th day of the disease, the man developed a hydrocele on the right. Type 2 dengue virus was detected in blood, urine, and saliva by polymerase chain reaction in both patients. The man was discharged on the 20th day of his illness with asthenovegetative and dyspeptic symptoms that persisted for several weeks. The woman was discharged on the 17th day of her illness with residual asthenovegetative manifestations and secondary thrombocytopenia lasting several years.</p></abstract><trans-abstract xml:lang="ru"><p>Лихорадка денге является наиболее распространенной в тропических и субтропических странах зооантропонозной инфекцией с трансмиссивным механизмом передачи вируса. В первые два десятилетия XXI в. зарегистрирован значительный подъем заболеваемости лихорадкой денге более чем в 120 странах мира. В статье представлен семейный завозной случай лихорадки денге у мужчины 34 лет и женщины 35 лет, которые заболели в течение 3 дней после возвращения из Таиланда (острова Пхукет). В обоих случаях наблюдалось острое начало болезни с повышения температуры тела до 39–40°С, резкой слабости, выраженных мышечных и суставных болей, сильной головной боли, тошноты, одно-двукратного жидкого стула. Лечились самостоятельно от острого респираторного заболевания. За медицинской помощью заболевшие обратились на 4, 5-й дни болезни и были госпитализированы в инфекционную больницу. Заболевание сопровождалось развитием заднешейного и подчелюстного лимфаденита, гепатомегалией, необильной пятнисто-папулезной сыпью на коже туловища и рук, единичными точечными геморрагиями, выраженной тромбоцито- и лейкопенией. У женщины на 6-й день болезни рентгенологически обнаружен перибронхиальный отек интерстиция. У мужчины на 7-й день заболевания развилось гидроцеле справа. РНК вируса денге 2-го типа обнаружен в крови, моче, слюне методом полимеразной цепной реакции у обоих пациентов. Мужчина выписан на 20-й день болезни с астеновегетативными и диспептическими явлениями, которые сохранялись в течение нескольких недель. Женщина выписана на 17-й день болезни с остаточными астеновегетативными проявлениями и вторичной тромбоцитопенией длительностью несколько лет.</p></trans-abstract><kwd-group xml:lang="en"><kwd>dengue fever</kwd><kwd>imported hemorrhagic fever</kwd><kwd>Aedes mosquito</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лихорадка денге</kwd><kwd>завозная геморрагическая лихорадка</kwd><kwd>комар рода Aedes</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Rachmawati Y, Ekawardhani S, Fauziah N, et al. 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