Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya63467410.26442/00403660.2025.04.203161ReviewsОбзорыReview ArticleMicroRNA-499a in heart diseases: prospects for use in diagnostics. A reviewМикроРНК-499a при заболеваниях сердца: перспективы использования в диагностикеhttps://orcid.org/0000-0001-7844-3328PisklovaMaria V.ПискловаМария Владиславовна
Russian Federation

аспирант ФГАОУ ВО «РНИМУ им. Н.И. Пирогова», лаборант-исследователь Лаб. функциональной геномики сердечно-сосудистых заболеваний

pisklova_maria@mail.ruhttps://orcid.org/0000-0001-8767-2958BaulinaNatalia M.БаулинаНаталья Михайловна
Russian Federation

канд. биол. наук, старший научный сотрудник Научно-исследовательской лаб. «Медицинская геномика» ФГАОУ ВО «РНИМУ им. Н.И. Пирогова», старший научный сотрудник Лаб. функциональной геномики сердечно-сосудистых заболеваний

pisklova_maria@mail.ruhttps://orcid.org/0000-0003-3366-4113KiselevIvan S.КиселевИван Сергеевич
Russian Federation

канд. биол. наук, старший научный сотрудник Научно-исследовательской лаб. «Медицинская геномика» ФГАОУ ВО «РНИМУ им. Н.И. Пирогова», старший научный сотрудник Лаб. функциональной геномики сердечно-сосудистых заболеваний

pisklova_maria@mail.ruhttps://orcid.org/0000-0002-5271-6698FavorovaOlga O.ФавороваОльга Олеговна
Russian Federation

доктор биол. наук, профессор, профессор кафедры молекулярной биологии и мед. биотехнологии медико-биологического фак-та, главный научный сотрудник Научно-исследовательской лаборатории «Медицинская геномика» ФГАОУ ВО «РНИМУ им. Н.И. Пирогова», рук. лаборатории функциональной геномики сердечно-сосудистых заболеваний

pisklova_maria@mail.ruPirogov Russian National Research Medical University (Pirogov University)ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский Университет)Chazov National Medical Research Center of CardiologyФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава России08052025974Вопросы диагностики3533592907202429072024Copyright ©; 2025, Consilium MedicumCopyright ©; 2025, ООО "Консилиум Медикум"2025Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/634674

Cardiac-specific (or myomiR) miRNA-499a (miR-499a) is a small (21–22 bp) non-coding RNA that is involved in the regulation of cardiac function both under normal and in various pathological conditions. Every year new studies expand the range of known biological processes that are regulated by miR-499a in the heart. In acute and chronic cardiovascular diseases accompanied by cardiomyocyte damage, miR-499a enters the bloodstream and can circulate there for a long time. At the same time, it is detected in plasma significantly earlier than traditional protein biomarkers, which makes it a new promising biomarker for early diagnosis and prognosis of heart diseases. This review describes the functions of human miR-499a and its involvement in the development of heart diseases. The data indicating the high diagnostic value of this miRNA in blood are presented.

Кардиоспецифическая микроРНК-499а (miR-499a) – небольшая (21–22 нуклеотида) некодирующая РНК, которая вовлечена в регуляцию функционирования сердца как в норме, так и при различных патологических состояниях. С каждым годом появляются все новые исследования, расширяющие круг известных биологических процессов, которые подвержены воздействиям miR-499a в миокарде. При острых и хронических заболеваниях сердечно-сосудистой системы, сопровождающихся повреждением кардиомиоцитов, miR-499a попадает в кровоток и может длительное время там циркулировать. При этом она выявляется в плазме значительно раньше традиционных белковых маркеров, что делает ее новым перспективным биомаркером для ранней диагностики и прогнозирования распространенных заболеваний сердца. В обзоре описаны функции miR-499a человека и ее вовлеченность в развитие заболеваний сердца. Приводятся данные, свидетельствующие о высокой диагностической значимости определения уровня этой микроРНК в крови.

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