Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya63247610.26442/00403660.2024.05.202698Original articlesОригинальные статьиResearch ArticleUric acid, cognitive disorders, neurodegenerationМочевая кислота, когнитивные расстройства, нейродегенерацияhttps://orcid.org/0000-0003-1191-5831234726518002524-7320EliseevMaxim S.ЕлисеевМаксим Сергеевич
Russian Federation

кандидат мед. наук, зав. лаб. микрокристаллических артритов

elicmax@yandex.ruhttps://orcid.org/0000-0002-5394-7869571960435998038-6195ZheliabinaOlga V.ЖелябинаОльга Владимировна
Russian Federation

младший научный сотрудник

olga-sheliabina@mail.ruhttps://orcid.org/0000-0002-1598-836071026147115162-6484NasonovEvgeny L.НасоновЕвгений Львович
Russian Federation

акад. РАН, доктор мед. наук, проф., науч. рук. ФГБНУ «НИИ ревматологии им. В.А. Насоновой», проф. каф. внутренних, профессиональных болезней и ревматологии

nasonov@irramn.ruNasonova Research Institute of RheumatologyФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Sechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)03062024965Issues of rheumatologyВопросы ревматологии4474522205202429052024Copyright ©; 2024, Consilium MedicumCopyright ©; 2024, ООО "Консилиум Медикум"2024Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/632476

This article examines the role of uric acid (UA) in cognitive changes and neurodegeneration, focusing on its functions as an antioxidant and prooxidant. Research suggests that changes in serum UA levels may be associated with the development or delay of cognitive impairment, especially in the context of neurodegenerative diseases such as Alzheimer's disease. It was revealed that there is a relationship between the level of UA and the dynamics of cognitive functions, indicating the potential neuroprotective properties of UA. Particular attention is paid to the balance between the antioxidant and prooxidant properties of UA, which may play a key role in protecting neurons from damage. However, research results are not clear-cut, highlighting the need for further research to more fully understand the role of UA in cognitive processes. Determining the optimal serum UA level may be an important step in developing strategies for the prevention and treatment of cognitive impairment associated with neurodegeneration. Overall, these studies advance the understanding of the mechanisms underlying the interaction between uric acid metabolism and brain health.

В данной статье рассматривается роль мочевой кислоты (МК) в когнитивных изменениях и нейродегенерации, акцентируется внимание на ее функциях как антиоксиданта и прооксиданта. Исследования показывают, что изменения уровней МК в сыворотке крови могут быть связаны с развитием или замедлением когнитивных нарушений, особенно в контексте нейродегенеративных заболеваний, таких как болезнь Альцгеймера. Выявлено, что существует взаимосвязь между уровнем МК и динамикой когнитивных функций, указывая на потенциальные нейропротекторные свойства МК. Особое внимание уделяется балансу между антиоксидантными и прооксидантными свойствами МК, который может играть ключевую роль в защите нейронов от повреждения. Однако результаты работ не являются однозначными, подчеркивая необходимость дальнейших исследований для более полного понимания роли МК в когнитивных процессах. Определение оптимального уровня МК в сыворотке может стать важным шагом в разработке стратегий профилактики и лечения когнитивных нарушений, связанных с нейродегенерацией. В целом данные исследования расширяют понимание механизмов, лежащих в основе взаимодействия между метаболизмом МК и здоровьем мозга.

uric acidneurodegenerationcognitive functionantioxidantprooxidantмочевая кислотанейродегенерациякогнитивные функцииантиоксидантпрооксидантThe study was conducted as a part of an applied research project with state registration No. 123041800013-3.Работа выполнена в рамках прикладного научного исследования, государственный регистрационный №123041800013-3Mijailovic NR, Vesic K, Borovcanin MM. The Influence of Serum Uric Acid on the Brain and Cognitive Dysfunction. Front Psychiatr. 2022;13. DOI:10.3389/fpsyt.2022.828476Wang T, Wu Y, Sun Y, et al. A Prospective Study on the Association between Uric Acid and Cognitive Function among Middle-Aged and Older Chinese. J Alzheimers Dis. 2017;58(1):79-86. DOI:10.3233/JAD-161243Chen-Xu M, Yokose C, Rai SK, et al. Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007–2016. Arthritis Rheumatol. 2019;71(6):991-9. DOI:10.1002/art.40807Kuwabara M, Fukuuchi T, Aoki Y, et al. Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases. Biomolecules. 2023;13(10):1519. DOI:10.3390/biom13101519Baddeley A. Working memory: theories, models, and controversies. Annu Rev Psychol. 2012;63:1-29. DOI:10.1146/annurev-psych-120710-100422Zhu Z, Zwerling JL, Qi X, et al. Mechanisms of Change in Cognitive Function Domains Among Older Adults in Cognitive Deterioration and Improvement Groups: Evidence From Phenotypic Network Structure. J Am Med Dir Assoc. 2023;24(12):2009-16.e9. DOI:10.1016/j.jamda.2023.08.022Jaeggi SM, Buschkuehl M, Jonides J, et al. Improving fluid intelligence with training on working memory. Proc Natl Acad Sci U S A. 2008;105(19):6829-33. DOI:10.1073/pnas.0801268105Guerreiro S, Privat AL, Bressac L, Toulorge D. CD38 in Neurodegeneration and Neuroinflammation. Cells. 2020;9(2):471. DOI:10.3390/cells9020471Arvanitakis Z, Shah RC, Bennett DA. Diagnosis and Management of Dementia: Review. JAMA. 2019;322(16):1589-99. DOI:10.1001/jama.2019.4782Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-46. DOI:10.1016/S0140-6736(20)30367-6Tang X, Song Z-H, Cardoso MA, et al. The relationship between uric acid and brain health from observational studies. Metab Brain Dis. 2022;37(6):1989-2003. DOI:10.1007/s11011-022-01016-2Fumagalli M, Lecca D, Abbracchio MP, Ceruti S. Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases. Front Pharmacol. 2017;8:941. DOI:10.3389/fphar.2017.00941Orowan E. The origin of man. Nature. 1955;175(4459):683-4. DOI:10.1038/175683a0Stetten D Jr, Hearon JZ. Intellectual level measured by army classification battery and serum uric acid concentration. Science. 1959;129(3365):1737. DOI:10.1126/science.129.3365.1737Liu Q, Peng M, Yang T, Si G. Uric acid levels and risk of cognitive impairment: Dose-response meta-analysis of prospective cohort studies. PLoS One. 2023;18(11):e0293832. DOI:10.1371/journal.pone.0293832Huang S, Wang J, Fan DY, et al. The association of serum uric acid with cognitive impairment and ATN biomarkers. Front Aging Neurosci. 2022;14:943380. DOI:10.3389/fnagi.2022.943380Min KH, Kang SO, Oh SJ, et al. Association Between Gout and Dementia in the Elderly: A Nationwide Population-Based Cohort Study. Am J Geriatr Psychiatr. 2021;29(12):1177-85. DOI:10.1016/j.jagp.2021.01.016Merighi S, Nigro M, Travagli A, et al. A2A Adenosine Receptor: A Possible Therapeutic Target for Alzheimer's Disease by Regulating NLRP3 Inflammasome Activity? Int J Mol Sci. 2022;23(9):5056. DOI:10.3390/ijms23095056Насонов Е.Л., Елисеев М.С. Роль интерлейкина 1 в развитии заболеваний человека. Научно-практическая ревматология. 2016;54(1):60-77 [Nasonov EL, Eliseev MS. Role of interleukin 1 in the development of human diseases. Rheumatology Science and Practice. 2016;54(1):60-77 (in Russian)]. DOI:10.14412/1995-4484-2016-60-77Wang J, Jin R, Wu Z, et al. Moderate increase of serum uric acid within a normal range is associated with improved cognitive function in a non-normotensive population: A nationally representative cohort study. Front Aging Neurosci. 2022;14:944341. DOI:10.3389/fnagi.2022.944341Liu Q, Liao X, Pan Y, et al. Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study. Neuropsychiatr Dis Treat. 2021;17:991-9. DOI:10.2147/NDT.S300893Kawada T. Serum uric acid and dementia subtype. Neurol Sci. 2023;44(8):2951. DOI:10.1007/s10072-023-06798-6Johnson RJ, Tolan DR, Bredesen D, et al. Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? Am J Clin Nutr. 2023;117(3):455-66. DOI:10.1016/j.ajcnut.2023.01.002Du N, Xu D, Hou X, et al. Inverse Association Between Serum Uric Acid Levels and Alzheimer's Disease Risk. Mol Neurobiol. 2016;53(4):2594-9. DOI:10.1007/s12035-015-9271-6Chen X, Guo X, Huang R, et al. Serum uric acid levels in patients with Alzheimer's disease: a meta-analysis. PLoS One. 2014;9(4):e94084. DOI:10.1371/journal.pone.0094084Cervellati C, Cremonini E, Bosi C, et al. Systemic oxidative stress in older patients with mild cognitive impairment or late onset Alzheimer's disease. Curr Alzheimer Res. 2013;10(4):365-72. DOI:10.2174/1567205011310040003Beydoun MA, Beydoun HA, Gamaldo AA, et al. Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health. 2014;14:643. DOI:10.1186/1471-2458-14-643Seifar F, Dinasarapu AR, Jinnah HA. Uric Acid in Parkinson's Disease: What Is the Connection? Mov Disord. 2022;37(11):2173-83. DOI:10.1002/mds.29209Tahavvori A, Gargari MK, Yazdani Y, et al. Involvement of antioxidant enzymes in Parkinson's disease. Pathol Res Pract. 2023;249:154757. DOI:10.1016/j.prp.2023.154757Euser SM, Hofman A, Westendorp RG, Breteler MM. Serum uric acid and cognitive function and dementia. Brain. 2009(Pt. 2): 132:377-82. DOI:10.1093/brain/awn316Verhaaren BF, Vernooij MW, Dehghan A, et al. The relation of uric acid to brain atrophy and cognition: The Rotterdam Scan Study. Neuroepidemiology. 2013;41:29-34. DOI:10.1159/000346606Hong JY, Lan TY, Tang GJ, et al. Gout and the risk of dementia: A nationwide population-based cohort study. J Arthritis Res Ther. 2015;17:139. DOI:10.1186/s13075-015-0642-1Li Q, Cen K, Cui Y, et al. Uric acid levels and their association with vascular dementia and Parkinson's disease dementia: a meta-analysis. Neurol Sci. 2023;44(6):2017-24. DOI:10.1007/s10072-023-06620-3Kawada T, Anang JB, Postuma R. Predictors of dementia in Parkinson disease: a prospective cohort study. Neurology. 2015;84(12):1285. DOI:10.1212/WNL.0000000000001408Latourte A, Soumaré A, Bardin T, et al. Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study. Ann Rheum Dis. 2018;77(3):328-35. DOI:10.1136/annrheumdis-2016-210767Scheepers LEJM, Jacobsson LTH, Kern S, et al. Urate and risk of Alzheimer's disease and vascular dementia: A population-based study. Alzheimers Dement. 2019;15(6):754-63. DOI:10.1016/j.jalz.2019.01.014Salam AP, Borsini A, Zunszain PA. Trained innate immunity: a salient factor in the pathogenesis of neuroimmune psychiatric disorders. Mol Psychiatry. 2018;23(2):170-6. DOI:10.1038/mp.2017.186Noz MP, Ter Telgte A, Wiegertjes K, et al. Trained Immunity Characteristics Are Associated With Progressive Cerebral Small Vessel Disease. Stroke. 2018;49(12):2910-7. DOI:10.1161/STROKEAHA.118.023192Sfera A, Gradini R, Cummings M, et al. Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease. Front Neurol. 2018;9:1062. DOI:10.3389/fneur.2018.01062Cabău G, Crișan TO, Klück V, et al. Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia. Immunol Rev. 2020;294(1):92-105. DOI:10.1111/imr.12833Tanaka T, Milaneschi Y, Zhang Y, et al. A double blind placebo controlled randomized trial of the effect of acute uric acid changes on inflammatory markers in humans: a pilot study. PLoS ONE. 2017;12(8):1-19. DOI:10.1371/journal.pone.0181100