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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">630469</article-id><article-id pub-id-type="doi">10.26442/00403660.2024.04.202607</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические наблюдения</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Remote electrocardiogram monitoring in cancer patients for detecting cardiotoxicity. Case report</article-title><trans-title-group xml:lang="ru"><trans-title>Дистанционное мониторирование электрокардиограммы у онкологических пациентов как метод выявления кардиотоксичности: клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3541-6041</contrib-id><name-alternatives><name xml:lang="en"><surname>Mesitskaya</surname><given-names>Dinara F.</given-names></name><name xml:lang="ru"><surname>Меситская</surname><given-names>Динара Фератовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. кардиологии, функциональной и ультразвуковой диагностики Института клинической медицины им. Н.В. Склифосовского</p></bio><email>aranid980@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3009-4143</contrib-id><name-alternatives><name xml:lang="en"><surname>Yasneva</surname><given-names>Anastasia S.</given-names></name><name xml:lang="ru"><surname>Яснева</surname><given-names>Анастасия Станиславовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>студентка Института клинической медицины им. Н.В. Склифосовского</p></bio><email>aranid980@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5473-3101</contrib-id><name-alternatives><name xml:lang="en"><surname>Fashafsha</surname><given-names>Zaki Z.</given-names></name><name xml:lang="ru"><surname>Фашафша</surname><given-names>Заки Зиядович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>науч. сотр. Института персонализированной кардиологии научно-исследовательского центра мирового уровня «Цифровой биодизайн и персонализированное здравоохранение»</p></bio><email>aranid980@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4535-8685</contrib-id><name-alternatives><name xml:lang="en"><surname>Kopylov</surname><given-names>Philipp Yu.</given-names></name><name xml:lang="ru"><surname>Копылов</surname><given-names>Филипп Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, проф., дир. Института персонализированной кардиологии научно-исследовательского центра мирового уровня «Цифровой биодизайн и персонализированное здравоохранение»</p></bio><email>aranid980@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0276-7374</contrib-id><name-alternatives><name xml:lang="en"><surname>Andreev</surname><given-names>Denis A.</given-names></name><name xml:lang="ru"><surname>Андреев</surname><given-names>Денис Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. кардиологии, функциональной и ультразвуковой диагностики Института клинической медицины им. Н.В. Склифосовского</p></bio><email>aranid980@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-05-02" publication-format="electronic"><day>02</day><month>05</month><year>2024</year></pub-date><volume>96</volume><issue>4</issue><issue-title xml:lang="en">Issues of diagnostics of internal diseases</issue-title><issue-title xml:lang="ru">Вопросы диагностики внутренних болезней</issue-title><fpage>386</fpage><lpage>390</lpage><history><date date-type="received" iso-8601-date="2024-04-18"><day>18</day><month>04</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-04-18"><day>18</day><month>04</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/630469">https://ter-arkhiv.ru/0040-3660/article/view/630469</self-uri><abstract xml:lang="en"><p>Cardiotoxicity is the direct adverse effect of anticancer agents on the function or structure of the heart, occurring both during treatment and many years later. The manifestations of cardiotoxicity can be very different: heart failure, coronary heart disease, cardiomyopathy, myocarditis, pericarditis, and arrhythmias, including atrial fibrillation (AF). The incidence of AF in the cancer patient population during therapy is 20–30%. Current options of remote electrocardiogram monitoring ensure the timely detection and treatment of AF in cancer patients, including the administration of anticoagulants. The article presents a clinical case of a 59-year-old patient with squamous cell carcinoma of the lower third of the esophagus after the first course of the TPF polychemotherapy regimen (docetaxel, cisplatin, 5-fluorouracil) with AF detected using a single-channel electrocardiogram monitor in a smartphone case.</p></abstract><trans-abstract xml:lang="ru"><p>Кардиотоксичность – прямое неблагоприятное воздействие противораковых препаратов на функцию или структуру сердца, возникающее как во время лечения, так и через много лет после него. Проявления кардиотоксичности могут быть самыми различными: сердечная недостаточность, ишемическая болезнь сердца, кардиомиопатия, миокардит, перикардит и аритмии, в том числе фибрилляция предсердий (ФП). Частота выявления ФП в популяции онкологических пациентов, проходящих терапию, составляет 20–30%. Современные возможности дистанционного мониторинга электрокардиограммы обеспечивают своевременное выявление и лечение ФП у онкологических пациентов, в том числе назначение антикоагулянтов. В статье представлен клинический случай пациента 59 лет с плоскоклеточным раком нижней трети пищевода, у которого после 1-го курса полихимиотерапии по схеме TPF (доцетаксел, цисплатин, 5-фторурацил) выявлена ФП с помощью одноканального монитора электрокардиограммы в чехле смартфона.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cardiotoxicity</kwd><kwd>remote monitoring</kwd><kwd>chemotherapy</kwd><kwd>anticoagulants</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кардиотоксичность</kwd><kwd>дистанционное мониторирование</kwd><kwd>химиотерапия</kwd><kwd>антикоагулянты</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Xiao D, Li J, Liu Y, et al. Emerging trends and hotspots evolution in cardiotoxicity: A bibliometric and knowledge-Map analysis From 2010 to 2022. Front Cardiovasc Med. 2023;10:1089916. DOI:10.3389/fcvm.2023.1089916</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hajjar LA, Fonseca SMR, Machado TIV. Atrial fibrillation and cancer. Front Cardiovasc Med. 2021;8:590768. DOI:10.3389/fcvm.2021.590768</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Jakobsen CB, Lamberts M, Carlson N, et al. Incidence of atrial fibrillation in different major cancer subtypes: A Nationwide population-based 12 year follow up study. BMC Cancer. 2019;19(1):1105. DOI:10.1186/s12885-019-6314-9</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Lancellotti P, Marechal P, Donis N, Oury C. Inflammation, cardiovascular disease, and cancer: A common link with far-reaching implications. Eur Heart J. 2019;40(48):3910-2. DOI:10.1093/eurheartj/ehz645</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Alexandre J, Salem JE, Moslehi J, et al. Identification of anticancer drugs associated with atrial fibrillation: analysis of the WHO pharmacovigilance database. Eur Heart J Cardiovasc Pharmacother. 2021;7(4):312-20. DOI:10.1093/ehjcvp/pvaa037</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Herrmann J. Adverse cardiac effects of cancer therapies: Cardiotoxicity and arrhythmia. Nat Rev Cardiol. 2020;17(8):474-502. DOI:10.1038/s41569-020-0348-1</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Ahmad J, Thurlapati A, Thotamgari S, et al. Anti-cancer drugs associated atrial fibrillation-an analysis of real-world pharmacovigilance data. Front Cardiovasc Med. 2022;9:739044. DOI:10.3389/fcvm.2022.739044</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Riess H, Ay C, Bauersachs R, et al. Use of direct oral anticoagulants in patients with cancer: Practical considerations for the management of patients with nausea or vomiting. Oncologist. 2018;23(7):822-39. DOI:10.1634/theoncologist.2017-0473</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Grymonprez M, De Backer TL, Bertels X, et al. Long-term comparative effectiveness and safety of dabigatran, rivaroxaban, apixaban and edoxaban in patients with atrial fibrillation: A nationwide cohort study. Front Pharmacol. 2023;14:1125576. DOI:10.3389/fphar.2023.1125576</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Ording AG, Horváth-Puhó E, Adelborg K, et al. Thromboembolic and bleeding complications during oral anticoagulation therapy in cancer patients with atrial fibrillation: A Danish nationwide population-based cohort study. Cancer Med. 2017;6(6):1165-72. DOI:10.1002/cam4.1054</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Angelini DE, Radivoyevitch T, McCrae KR, Khorana AA. Bleeding incidence and risk factors among cancer patients treated with anticoagulation. Am J Hematol. 2019;94(7):780-5. DOI:10.1002/ajh.25494</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Wu VC, Wang CL, Huang YT, et al. Novel oral anticoagulant versus warfarin in cancerpatients with atrial fibrillation: An 8-year population-based cohort study. J Cancer. 2020;11:92-9. DOI:10.7150/jca.36468</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Deng Y, Tong Y, Deng Y, et al. Non-vitamin K antagonist oral anticoagulants versus warfarin in patients with cancer and atrial fibrillation: A systematic review and meta-analysis. J Am Heart Assoc. 2019;8(14):e012540. DOI:10.1161/JAHA.119.012540</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Cavallari I, Verolino G, Romano S, Patti G. Efficacy and safety of nonvitamin K oral anticoagulants in patients with atrial fibrillation and cancer: A study-level metaanalysis. Thromb Haemost. 2020;120(2):314-21. DOI:10.1055/s-0039-3400300</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Sawant AC, Kumar A, McCray W, et al. Superior safety of direct oral anticoagulants compared to Warfarin in patients with atrial fibrillation and underlying cancer: A national veterans affairs database study. J Geriatr Cardiol. 2019;16(9):706-9. DOI:10.11909%2Fj.issn.1671-5411.2019.09.006</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Shah S, Norby FL, Datta YH, et al. Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation. Blood Adv. 2018;2(3):200-9. DOI:10.1182/bloodadvances.2017010694</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Melloni C, Dunning A, Granger CB, et al. Efficacy and safety of apixaban versus warfarin in patients with atrial fibrillation and a history of cancer: Insights from the ARISTOTLE Trial. Am J Med. 2017;130(12):1440-48.e1. DOI:10.1016/j.amjmed.2017.06.026</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Haverkamp HT, Fosse SO, Schuster P. Accuracy and usability of single-lead ECG from smartphones – A clinical study. Indian Pacing Electrophysiol J. 2019;19(4):145-9. DOI:10.1016/j.ipej.2019.02.006</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Manetas-Stavrakakis N, Sotiropoulou IM, Paraskevas T, et al. Accuracy of artificial intelligence-based technologies for the diagnosis of atrial fibrillation: A systematic review and meta-analysis. J Clin Med. 2023;12(20):6576. DOI:10.3390/jcm12206576</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Badheeb AM, Ahmed F, Alzahrani HA, et al. Cancer therapy-related cardiotoxicity: A comprehensive retrospective analysis at Najran Cancer Center, Saudi Arabia. Cureus. 2023;15(7):e41287. DOI:10.7759/cureus.41287</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Costa IBSDS, Bittar CS, Fonseca SMR, et al. Brazilian cardio-oncology: The 10-year experience of the Instituto do Cancer do Estado de Sao Paulo. BMC Cardiovasc Disord. 2020;20(1):206. DOI:10.1186/s12872-020-01471-8</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Brandão SR, Carvalho F, Amado F, et al. Insights on the molecular targets of cardiotoxicity induced by anticancer drugs: A systematic review based on proteomic findings. Metabolism. 2022;134:155250. DOI:10.1016/j.metabol.2022.155250</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Jain D, Aronow W. Cardiotoxicity of cancer chemotherapy in clinical practice. Hosp Pract (1995). 2019;47(1):6-15. DOI:10.1080/21548331.2018.1530831</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Alexandre J, Boismoreau L, Morice PM, et al. Atrial fibrillation incidence associated with exposure to anticancer drugs used as monotherapy in clinical trials. JACC CardioOncol. 2023;5(2):216-26. DOI:10.1016/j.jaccao.2022.11.019</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Adhikari A, Asdaq SMB, Al Hawaj MA, et al. Anticancer drug-induced cardiotoxicity: Insights and pharmacogenetics. Pharmaceuticals (Basel). 2021;14(10):970. DOI:10.3390/ph14100970</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Lobenwein D, Kocher F, Dobner S, et al. Cardiotoxic mechanisms of cancer immunotherapy – A systematic review. Int J Cardiol. 2021;323:179-87. DOI:10.1016/j.ijcard.2020.08.033</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Moriyama S, Yokoyama T, Irie K, et al. Atrial fibrillation observed in a patient with esophageal cancer treated with fluorouracil. J Cardiol Cases. 2019;20(5):183-6. DOI:10.1016/j.jccase.2019.08.005</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Peng H, Chen B, He S, et al. Efficacy and toxicity of three induction chemotherapy regimens in locoregionally advanced nasopharyngeal carcinoma: Outcomes of 10-year follow-up. Front Oncol. 2021;11:765378. DOI:10.3389/fonc.2021.765378</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Diederichsen SZ, Haugan KJ, Brandes A, et al. Natural history of subclinical atrial fibrillation detected by implanted loop recorders. J Am Coll Cardiol. 2019;74(22):2771-81. DOI:10.1016/j.jacc.2019.09.050</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Gognieva D, Vishnyakova N, Mitina Y, et al. Remote screening for atrial fibrillation by a federal cardiac monitoring system in primary care patients in Russia: Results from the Prospective Interventional Multicenter FECAS-AFS Study. Glob Heart. 2022;17(1):4. DOI:10.5334/gh.1057</mixed-citation></ref></ref-list></back></article>
