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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">629646</article-id><article-id pub-id-type="doi">10.26442/00403660.2024.02.202583</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Fixed combination of non-steroidal anti-inflammatory drug and muscle relaxant as the basis for rational therapy of pain syndromes: A review</article-title><trans-title-group xml:lang="ru"><trans-title>Фиксированная комбинация нестероидного противовоспалительного препарата и миорелаксанта как основа рациональной терапии болевых синдромов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8655-8501</contrib-id><name-alternatives><name xml:lang="en"><surname>Putilina</surname><given-names>Marina V.</given-names></name><name xml:lang="ru"><surname>Путилина</surname><given-names>Марина Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, проф., проф. каф. клинической фармакологии лечебного фак-та</p></bio><email>profput@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-03-30" publication-format="electronic"><day>30</day><month>03</month><year>2024</year></pub-date><volume>96</volume><issue>2</issue><issue-title xml:lang="en">Issues of gastroenterology</issue-title><issue-title xml:lang="ru">Вопросы гастроэнтерологии</issue-title><fpage>176</fpage><lpage>180</lpage><history><date date-type="received" iso-8601-date="2024-03-29"><day>29</day><month>03</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-03-29"><day>29</day><month>03</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/629646">https://ter-arkhiv.ru/0040-3660/article/view/629646</self-uri><abstract xml:lang="en"><p>The incidence of pain in the lower back ranges from 10% to 25% of all cases of algia. 37–64.7% of the world's population have muscle spasms of varying severity during an exacerbation of pain. The problem of pain therapy is far from being solved. Achieving greater or equal pain relief can be achieved through combination drug therapy, where drugs have different mechanisms of action or combine pharmacokinetic properties to produce a synergistic effect. Fixed combinations of non-steroidal anti-inflammatory drugs and a muscle relaxant (chlorzoxazone 500 mg and ibuprofen 400 mg) are the basis of rational therapy, allowing them to achieve a number of clinical and pharmacological advantages.</p></abstract><trans-abstract xml:lang="ru"><p>Боли в нижней части спины встречаются в 10–25% всех случаев алгий. Во время обострения боли мышечный спазм разной степени выраженности отмечают 37–64,7% населения планеты. Проблема терапии боли далека от решения. Большее или равное ее облегчение может быть достигнуто с помощью комбинированной лекарственной терапии, при которой назначают препараты, имеющие разные механизмы действия или сочетающиеся фармакокинетические свойства, благодаря чему достигается синергический эффект. Фиксированные комбинации нестероидных противовоспалительных препаратов и миорелаксанта (хлорзоксазон 500 мг + ибупрофен 400 мг) составляют основу рациональной терапии, обладая рядом клинико-фармакологических преимуществ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>pain in the lower back</kwd><kwd>muscle spasm</kwd><kwd>non-steroidal anti-inflammatory drugs</kwd><kwd>muscle relaxant</kwd><kwd>ibuprofen</kwd><kwd>chlorzaxazone</kwd><kwd>synergistic effect</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>боль в нижней части спины</kwd><kwd>мышечный спазм</kwd><kwd>нестероидные противовоспалительные препараты</kwd><kwd>миорелаксант</kwd><kwd>ибупрофен</kwd><kwd>хлорзоксазон</kwd><kwd>синергический эффект</kwd></kwd-group><funding-group><funding-statement xml:lang="en">This study was supported by Dr. Reddy’s Laboratories company. 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