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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">625315</article-id><article-id pub-id-type="doi">10.26442/00403660.2023.12.202496</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Modern concept of differential diagnosis of colitis: from G.F. Lang to the present day. A review</article-title><trans-title-group xml:lang="ru"><trans-title>Современная концепция дифференциальной диагностики колитов: от Г.Ф. Ланга до наших дней</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9782-4860</contrib-id><name-alternatives><name xml:lang="en"><surname>Parfenov</surname><given-names>Asfold I.</given-names></name><name xml:lang="ru"><surname>Парфенов</surname><given-names>Асфольд Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>доктор медицинских наук, профессор, зав. отдела патологии кишечника</p></bio><email>asfold@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3818-6205</contrib-id><name-alternatives><name xml:lang="en"><surname>Kagramanova</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Каграманова</surname><given-names>Анна Валерьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>кандидат медицинских наук, ст. научный сотрудник отделения воспалительных заболеваний кишечника, ведущий специалист ГБУ НИИОЗММ</p></bio><email>asfold@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4308-8009</contrib-id><name-alternatives><name xml:lang="en"><surname>Khomeriki</surname><given-names>Sergey G.</given-names></name><name xml:lang="ru"><surname>Хомерики</surname><given-names>Сергей Германович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий лаб. Патоморфологии</p></bio><email>asfold@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0855-5217</contrib-id><name-alternatives><name xml:lang="en"><surname>Kulakov</surname><given-names>Dmitrii S.</given-names></name><name xml:lang="ru"><surname>Кулаков</surname><given-names>Дмитрий Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>мл. научный сотрудник отделения патологии кишечника, специалист организационно-методического отдела по колопроктологии ГБУ НИИОЗММ</p></bio><email>asfold@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Loginov Moscow Clinical Scientific Center</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Московский клинический научно-практический центр им. А.С. Логинова» Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Research Institute of Healthcare Organization and Medical Management</institution></aff><aff><institution xml:lang="ru">ГБУ «Научно-исследовательский институт организации здравоохранения и медицинского менеджмента» Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-12-28" publication-format="electronic"><day>28</day><month>12</month><year>2023</year></pub-date><volume>95</volume><issue>12</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>1022</fpage><lpage>1030</lpage><history><date date-type="received" iso-8601-date="2023-12-26"><day>26</day><month>12</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-12-26"><day>26</day><month>12</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/625315">https://ter-arkhiv.ru/0040-3660/article/view/625315</self-uri><abstract xml:lang="en"><p>The aim of the article is to improve the differential diagnosis of specific and nonspecific inflammatory bowel diseases. In Russia, this scientific direction is associated with the name of G.F. Lang, who performed in 1901–1902 the study „On ulcerative inflammation of the large intestine caused by balantidiasis“. The etiology of specific colitis is associated with infection with parasites, bacteria and viruses that cause inflammation of the intestinal wall, diarrhea, often with an admixture of mucus, pus and blood. Specific colitis (SC) may be accompanied by fever, abdominal pain, and tenesmus. Bacterial colitis is commonly caused by <italic>Salmonella, Shigella, Escherichia coli</italic>, <italic>Clostridium difficile</italic>, <italic>Campylobacter jejuni</italic>, <italic>Yersinia enterocolitica</italic>, and <italic>Mycobacterium tuberculosis</italic>. Viral colitis is caused by rotavirus, adenovirus, cytomegalovirus, and norovirus. Parasitic colitis can be caused by <italic>Entamoeba histolytica</italic> and balantidia. In gay people, SC can cause sexually transmitted infections: <italic>Neisseria gonorrhoeae, Chlamydia trachomatis</italic>, and treponema pallidum, affecting the rectum. Stool microscopy, culture, and endoscopy are used to establish the diagnosis. Stool culture helps in the diagnosis of bacterial colitis in 50% of patients, and endoscopic studies reveal only nonspecific pathological changes. Differential diagnosis of SC should be carried out with immune-inflammatory bowel diseases (ulcerative colitis, Crohn's disease, undifferentiated colitis), radiation colitis and other iatrogenic bowel lesions. The principles of diagnosis and therapy of inflammatory bowel diseases associated with various etiological </p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель статьи</bold> – усовершенствование дифференциальной диагностики специфических и неспецифических воспалительных заболеваний кишечника. В России это научное направление связано с именем Георгия Федоровича Ланга, который в 1901–1902 гг. провел исследование «О язвенном воспалении толстых кишок, вызванном балантидиазом». Этиология специфических колитов связана с заражением паразитами, бактериями и вирусами, которые вызывают воспаление стенки кишечника, диарею, часто с примесью слизи, гноя и крови. Специфический колит (СК) может сопровождаться лихорадкой, болями в животе и тенезмами. Возбудителями бактериального колита обычно служат сальмонеллы, шигеллы, кишечная палочка, <italic>Clostridium</italic><italic> </italic><italic>difficile</italic>, <italic>Campylobacter</italic><italic> </italic><italic>jejuni</italic>, <italic>Yersinia</italic><italic> </italic><italic>enterocolitica</italic> и микобактерии туберкулеза. Вирусный колит вызывают ротавирус, аденовирус, цитомегаловирус и норовирус. Паразитарный колит способны вызывать <italic>Entamoeba</italic><italic> </italic><italic>histolytica</italic> и балантидии. У лиц с нетрадиционной сексуальной ориентацией СК могут вызывать инфекции, передаваемые половым путем: <italic>Neisseria</italic><italic> </italic><italic>gonorrhoeae</italic><italic>, </italic><italic>Chlamydia</italic><italic> </italic><italic>trachomatis</italic> и бледная трепонема, поражающие прямую кишку. Для установления диагноза применяют микроскопию кала, посев и эндоскопию. Посев кала помогает в диагностике бактериального колита у 50% пациентов, а эндоскопические исследования выявляют лишь неспецифические патологические изменения. Дифференциальную диагностику СК следует проводить с иммуновоспалительными заболеваниями кишечника (язвенный колит, болезнь Крона, недифференцированный колит), лучевым колитом и другими ятрогенными поражениями кишечника. Обсуждаются принципы диагностики и терапии воспалительных заболеваний кишечника, сопряженные с разными этиологическими факторами.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ulcerative colitis</kwd><kwd>specific and nonspecific immune-inflammatory bowel diseases</kwd><kwd>pseudomembranous colitis</kwd><kwd>ischemic colitis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>язвенный колит</kwd><kwd>специфические и неспецифические воспалительные заболевания кишечника</kwd><kwd>псевдомембранозный колит</kwd><kwd>ишемический колит</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Образцов В.П. Болезни желудка, кишек и брюшины. [Киев], 1924 [Obraztsov VP. Bolezni zheludka, kishek i briushiny. [Kiev], 1924 (in Russian)].</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hawk WA, Turnbull Jr RB, Schofield PF. Nonspecific ulcerative colitis. 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