Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya6188510.26442/00403660.2021.01.200591Research ArticleFeatures of genetic manifestations in patients with abdominal obesity during atrial fibrillation in combination with arterial hypertensionHidirovaLyudmila D.h_ludmila73@mail.ruhttps://orcid.org/0000-0002-1250-8798YakhontovDavyd A.h_ludmila73@mail.ruhttps://orcid.org/0000-0003-4735-5178MaksimovVladimir N.h_ludmila73@mail.ruhttps://orcid.org/0000-0002-7165-4496Novosibirsk State Medical University2Institute of Internal and Preventive Medicine – branch of the Federal Research Center Institute of Cytology and Genetics1001202193141432502202125022021Copyright © 2021, Consilium Medicum2021<p><strong>Aim. </strong>To study the significance of the rs1378942 polymorphisms of the <em>CSK</em> gene and rs2200733 (chromosome 4q25) in the progression of AF in men with AH and AO.</p>
<p><strong>Materials and methods.</strong> In an observational cohort study, 116 men aged 4565 years were followed. Of these, 57 patients with AF, AH and AO and a control group including 59 patients with AF, AH and without AO. Testing of polymorphism rs1378942 of the <em>CSK</em> gene and rs2200733 of chromosome 4q25 using polymerase chain reaction with restriction fragment length polymorphism. All statistical calculations were performed using the Rstudio program (version 0.99.879 20092016 RStudio, Inc., USA).</p>
<p><strong>Results.</strong> The average age of all studied patients was 53.37.1 years. When dividing patients with AF and AH into groups based on the presence/absence of AO, it turned out that in the subgroups of carriers of different genotypes of the rs1378942 polymorphism of the CSK gene there are significant differences in BMI: in the group with BMI, there is an increase in the indicator in the series of <em>CC, AC, AA</em> genotypes. The highest BMI value in carriers of the <em>CC</em> genotype (<em>p</em>0.03) was in the group with AO. In the subgroups of carriers of different rs2200733 genotypes of chromosome 4q25,<em> CC</em> has the highest BMI (<em>p</em>0.05). It was proved that in the group with AO, the progression of AF occurred 2.57 times more often than in the group without AO (<em>p</em>0.003).</p>
<p><strong>Conclusion. </strong>In men with AF and AH, single nucleotide polymorphisms rs1378942 of the <em>CSK</em> gene and rs2200733 of chromosome 4q25 are associated with BMI. The heterozygous genotype <em>AC</em> rs1378942 in the <em>CSK</em> gene is significantly more common in patients, regardless of the presence of AO. In the group with AO, the progression of AF occurred 2.57 times more often than in the group without AO.</p>atrial fibrillationhypertensionobesityrs1378942 polymorphism of the CSK geners2200733 chromosome 4q25фибрилляция предсердийгипертоническая болезньабдоминальное ожирениеполиморфизмrs1378942генCSKrs2200733[Narkiewicz K. Obesity and hypertension – the issue is more complex than we thought. Nephrol Dial Transplant. 2006;21(2):264-7. doi: 10.1093/ndt/gfi290][Клинические рекомендации «Диагностика и лечение фибрилляции предсердий». М., 2017 [Clinical recommendations “Diagnosis and treatment of atrial fibrillation”. 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