<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">595931</article-id><article-id pub-id-type="doi">10.26442/00403660.2023.07.202282</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Diseases of the gastrointestinal tract in the context of COVID-19 infection: present and future challenges: A review</article-title><trans-title-group xml:lang="ru"><trans-title>Заболевания желудочно-кишечного тракта в контексте инфекции COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6114-564X</contrib-id><name-alternatives><name xml:lang="en"><surname>Maev</surname><given-names>Igor V.</given-names></name><name xml:lang="ru"><surname>Маев</surname><given-names>Игорь Вениаминович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>акад. РАН, д-р мед. наук, проф., проректор по учебной работе</p></bio><email>osadchuk.mikhail@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0485-6802</contrib-id><name-alternatives><name xml:lang="en"><surname>Osadchuk</surname><given-names>Mikhail A.</given-names></name><name xml:lang="ru"><surname>Осадчук</surname><given-names>Михаил Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. поликлинической терапии Института клинической медицины им. Н.В. Склифосовского</p></bio><email>osadchuk.mikhail@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Yevdokimov Moscow State University of Medicine and Dentistry</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-09-29" publication-format="electronic"><day>29</day><month>09</month><year>2023</year></pub-date><volume>95</volume><issue>7</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>586</fpage><lpage>590</lpage><history><date date-type="received" iso-8601-date="2023-09-29"><day>29</day><month>09</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-09-29"><day>29</day><month>09</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/595931">https://ter-arkhiv.ru/0040-3660/article/view/595931</self-uri><abstract xml:lang="en"><p>A significant prevalence of gastrointestinal symptoms in SARS-CoV-2 infection is also associated with its fecal-oral transmission, which leads to a progressive increase in the number of patients with diseases of the esophagus, stomach and intestines. In addition, intestinal infections caused by SARS-CoV-2 may be one of the main causes of functional long-term stress-related gastrointestinal disorders, united in the concept of post-COVID syndrome.</p></abstract><trans-abstract xml:lang="ru"><p>Значительная распространенность желудочно-кишечных симптомов при инфекции SARS-CoV-2 ассоциирована и с фекально-оральной ее передачей, что приводит к прогрессирующему увеличению числа больных с заболеваниями пищевода, желудка и кишечника. Кроме того, кишечные инфекции, вызванные SARS-CoV-2, могут выступать одной из основных причин функциональных длительно протекающих желудочно-кишечных расстройств, связанных со стрессом, объединенных в понятие пост-COVID-cиндрома.</p></trans-abstract><kwd-group xml:lang="en"><kwd>SARS-CoV-2</kwd><kwd>gastrointestinal tract</kwd><kwd>esophagus</kwd><kwd>stomach</kwd><kwd>intestines</kwd><kwd>post-COVID-syndrome</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>SARS-CoV-2</kwd><kwd>желудочно-кишечный тракт</kwd><kwd>пищевод</kwd><kwd>желудок</kwd><kwd>кишечник</kwd><kwd>пост-COVID-cиндром</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Янушевич О.О., Маев И.В., Крихели Н.И., и др. Распространенность и прогностическое значение гастроэнтерологических проявлений COVID-19: данные Российской университетской клиники. Терапевтический архив. 2021;93(8):853-61 [Ianushevich OO, Maev IV, Krikheli NI, et al. Prevalence and prognostic value of gastroenterological manifestations of COVID-19: data from the Russian University Clinic. Terapevticheskii Arkhiv (Ter. Arkh.). 2021;93(8):853-61 (in Russian)]. DOI:10.26442/00403660.2021.08.200977</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Holshue ML, DeBolt C, Lindquist S, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020;382(10):929-36. DOI:10.1056/NEJMoa2001191</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Fang D, Ma JD, Guan JL, et al. A single-center, descriptive study on the digestive system of COVID-19 inpatients in wuhan. Zhonghua Xiaohua Zazhi. 2020;40:E005.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Docherty AB, Harrison EM, Green CA, et al. Features of 20 133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020;369:m1985. DOI:10.1136/bmj.m1985</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Jones DL, Baluja MQ, Graham DW, et al. Shedding of SARS-CoV-2 in feces and urine and its potential role in person-to-person transmission and the environment-based spread of COVID-19. Sci Total Environ. 2020;749:141364. DOI:10.1016/j.scitotenv.2020.141364</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Lin L, Jiang X, Zhang Z, et al. Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut. 2020;69(6):997-1001. DOI:10.1136/gutjnl-2020-321013</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Chai X, Hu L, Zhang Y, et al. Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection. BioRxiv.org. 2020:2020.02.03.931766. DOI:10.1101/2020.02.03.931766</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection – a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020;9(1):727-32. DOI:10.1080/22221751.2020.1746199</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI:10.1001/jama.2020.1585</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Han C, Duan C, Zhang S, et al. Digestive Symptoms in COVID-19 Patients With Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes. Am J Gastroenterol. 2020;115(6):916-23. DOI:10.14309/ajg.0000000000000664</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Esposito G, Pesce M, Seguella L, et al. Can the enteric nervous system be an alternative entrance door in SARS-CoV-2 neuroinvasion? Brain Behav Immun. 2020;87:93-4. DOI:10.1016/j.bbi.2020.04.060</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Fang D, Ma J, Guan J, et al. Manifestations of Digestive system in hospitalized patients with novel coronavirus pneumonia in Wuhan, China: a single-center, descriptive study. Chinese Journal of Digestion. 2020:E005.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Gu J, Han B, Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission. Gastroenterology. 2020;158(6):1518-9. DOI:10.1053/j.gastro.2020.02.054</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Luo S, Zhang X, Xu H. Don’t Overlook Digestive Symptoms in Patients With 2019 Novel Coronavirus Disease (COVID-19). Clin Gastroenterol Hepatol. 2020;18(7):1636-7. DOI:10.1016/j.cgh.2020.03.043</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Zhang FC, Yin ZB, Tang XP. Clinical analysis of 260 cases of SARS in Guangzhou. Zhonghua Chuanranbing Zazhi. 2003;21:84-8.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Gao QY, Chen YX, Fang JY. 2019 Novel coronavirus infection and gastrointestinal tract. J Dig Dis. 2020;21(3):125-6. DOI:10.1111/1751-2980.12851</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Price E. Could the severity of COVID-19 be increased by low gastric acidity? Crit Care. 2020;24(1):456. DOI:10.1186/s13054-020-03182-0</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Hunt RH, East JE, Lanas A, et al. COVID-19 and Gastrointestinal Disease: Implications for the Gastroenterologist. Dig Dis. 2021;39(2):119-39. DOI:10.1159/000512152</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Manolis AS, Manolis TA, Manolis AA, et al. COVID-19 Infection: Viral Macro- and Micro-Vascular Coagulopathy and Thromboembolism/Prophylactic and Therapeutic Management. J Cardiovasc Pharmacol Ther. 2021;26(1):12-24. DOI:10.1177/1074248420958973</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Sultan S, Altayar O, Siddique SM, et al. AGA Institute Rapid Review of the Gastrointestinal and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19. Gastroenterology. 2020;159(1):320-34.e27. DOI:10.1053/j.gastro.2020.05.001</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Norsa L, Indriolo A, Sansotta N, et al. Uneventful Course in Patients With Inflammatory Bowel Disease During the Severe Acute Respiratory Syndrome Coronavirus 2 Outbreak in Northern Italy. Gastroenterology. 2020;159(1):371-2. DOI:10.1053/j.gastro.2020.03.062</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Cheung S, Quiwa JC, Pillai A, et al. Superior Mesenteric Artery Thrombosis and Acute Intestinal Ischemia as a Consequence of COVID-19 Infection. Am J Case Rep. 2020;21:e925753. DOI:10.12659/AJCR.925753</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Keshavarz P, Rafiee F, Kavandi H, et al. Ischemic gastrointestinal complications of COVID-19: a systematic review on imaging presentation. Clin Imaging. 2021;73:86-95. DOI:10.1016/j.clinimag.2020.11.054</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Singh B, Kaur P. COVID-19 and acute mesenteric ischemia: A review of literature. Hematol Transfus Cell Ther. 2021;43(1):112-6. DOI:10.1016/j.htct.2020.10.959</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Theoharides TC. COVID-19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin. Biofactors. 2020;46(3):306-8. DOI:10.1002/biof.1633</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Gu S, Chen Y, Wu Z, et al. Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza. Clin Infect Dis. 2020;71(10):2669-78. DOI:10.1093/cid/ciaa709</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Domínguez-Díaz C, García-Orozco A, Riera-Leal A, et al. Microbiota and Its Role on Viral Evasion: Is It With Us or Against Us? Front Cell Infect Microbiol. 2019;9:256. DOI:10.3389/fcimb.2019.00256</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Huang Y, Mao K, Chen X, et al. S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. Science. 2018;359(6371):114-9. DOI:10.1126/science.aam5809</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>McAleer JP, Kolls JK. Contributions of the intestinal microbiome in lung immunity. Eur J Immunol. 2018;48(1):39-49. DOI:10.1002/eji.201646721</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. Available at: https://apps.who.int/iris/bitstream/handle/10665/345824/WHO-2019-nCoV-Post-COVID-19-condition-Clinical-case-definition-2021.1-rus.pdf. Accessed: 26.02.2021.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>COVID-19 rapid guideline: managing the long-term effects of COVID-19 NICE guideline [NG188] Published: 18 December 2020. Last updated: 11 November 2021. Available at: https://www.nice.org.uk/guidance/NG188. Accessed: 26.02.2021.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Mahmoud MH, Alghamdi FA, Alghamdi GA, et al. Study of Post-COVID-19 Syndrome in Saudi Arabia. Cureus. 2021;13(9):e17787. DOI:10.7759/cureus.17787</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Petersen MS, Kristiansen MF, Hanusson KD, et al. Long COVID in the Faroe Islands: A Longitudinal Study Among Nonhospitalized Patients. Clin Infect Dis. 2021;73(11):e4058-63. DOI:10.1093/cid/ciaa1792</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis (Lond). 2021;53(10):737-54. DOI:10.1080/23744235.2021.1924397</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>DosSantos MF, Devalle S, Aran V, et al. Neuromechanisms of SARS-CoV-2: A Review. Front Neuroanat. 2020;14:37. DOI:10.3389/fnana.2020.00037</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Varatharaj A, Thomas N, Ellul MA, et al. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry. 2020;7(10):875-82. DOI:10.1016/S2215-0366(20)30287-X</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Ghoshal UC, Ghoshal U, Rahman MM, et al. Post-infection functional gastrointestinal disorders following coronavirus disease-19: A case-control study. J Gastroenterol Hepatol. 2021. DOI:10.1111/jgh.15717</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Schmulson M, Ghoshal UC, Barbara G. Managing the Inevitable Surge of Post-COVID-19 Functional Gastrointestinal Disorders. Am J Gastroenterol. 2021;116(1):4-7. DOI:10.14309/ajg.0000000000001062</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Ghoshal UC, Rahman MM. Post-infection irritable bowel syndrome in the tropical and subtropical regions: Vibrio cholerae is a new cause of this well-known condition. Indian J Gastroenterol. 2019;38(2):87-94. DOI:10.1007/s12664-019-00959-2</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397(10270):220-32. DOI:10.1016/S0140-6736(20)32656-8</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Weng J, Li Y, Li J, et al. Gastrointestinal sequelae 90 days after discharge for COVID-19. Lancet Gastroenterol Hepatol. 2021;6(5):344-6. DOI:10.1016/S2468-1253(21)00076-5</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Noviello D, Costantino A, Muscatello A, et al. Functional gastrointestinal and somatoform symptoms five months after SARS-CoV-2 infection: A controlled cohort study. Neurogastroenterol Motil. 2022;34(2):e14187. DOI:10.1111/nmo.14187</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Marshall JK, Thabane M, Borgaonkar MR, James C. Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen. Clin Gastroenterol Hepatol. 2007;5(4):457-60. DOI:10.1016/j.cgh.2006.11.025</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Zanini B, Ricci C, Bandera F, et al. Incidence of post-infectious irritable bowel syndrome and functional intestinal disorders following a water-borne viral gastroenteritis outbreak. Am J Gastroenterol. 2012;107(6):891-9. DOI:10.1038/ajg.2012.102</mixed-citation></ref></ref-list></back></article>
