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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">568394</article-id><article-id pub-id-type="doi">10.26442/00403660.2023.06.202234</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>History of medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>История медицины</subject></subj-group><subj-group subj-group-type="article-type"><subject>Miscellaneous</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Cardiorenal syndromes: historical aspects and current challenges</article-title><trans-title-group xml:lang="ru"><trans-title>Кардиоренальные синдромы: история и современность</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9558-363X</contrib-id><name-alternatives><name xml:lang="en"><surname>Nezhdanov</surname><given-names>Kirill S.</given-names></name><name xml:lang="ru"><surname>Нежданов</surname><given-names>Кирилл Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>аспирант каф. внутренних болезней ФГБОУ ВО «МГУ им. М.В. Ломоносова»</p></bio><email>nezhdK@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5599-0350</contrib-id><name-alternatives><name xml:lang="en"><surname>Milovanova</surname><given-names>Ludmila Y.</given-names></name><name xml:lang="ru"><surname>Милованова</surname><given-names>Людмила Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. внутренних, профессиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)</p></bio><email>nezhdK@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2291-6453</contrib-id><name-alternatives><name xml:lang="en"><surname>Strizhakov</surname><given-names>Leonid A.</given-names></name><name xml:lang="ru"><surname>Стрижаков</surname><given-names>Леонид Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. внутренних болезней ФГБОУ ВО «МГУ им. М.В. Ломоносова», проф. каф. внутренних, профессиональных болезней и ревматологии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)</p></bio><email>nezhdK@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7647-3942</contrib-id><name-alternatives><name xml:lang="en"><surname>Krasnova</surname><given-names>Tatiana N.</given-names></name><name xml:lang="ru"><surname>Краснова</surname><given-names>Татьяна Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, зав. каф. внутренних болезней ФГБОУ ВО «МГУ им. М.В. Ломоносова», доц. каф. внутренних болезней ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)</p></bio><email>nezhdK@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Lomonosov Moscow State University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-08-17" publication-format="electronic"><day>17</day><month>08</month><year>2023</year></pub-date><volume>95</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>521</fpage><lpage>525</lpage><history><date date-type="received" iso-8601-date="2023-08-14"><day>14</day><month>08</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-08-14"><day>14</day><month>08</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/568394">https://ter-arkhiv.ru/0040-3660/article/view/568394</self-uri><abstract xml:lang="en"><p>The article describes major milestones in acknowledgment of pathophysiological relationship between heart and kidneys since Ancient Egypt till our time and history of term “cardiorenal syndrome” (CRS). First references about kidney and heart functions could be dated to 13 BC when Hippocrates mentioned them. In the XIV century Gentile da Foligno proposed a hypothesis about functional interconnection between heart and kidneys. In the XVIII century Richard Bright described the link between myocardial hypertrophy and kidneys diseases. Frederic Justin Collet was the first one who used the term “cardiorenal” in his article in 1903. In Russia, I.I. Stolnikov conducted his experiments about myocardial hypertrophy and kidneys ischemia in 1880. Famous Russian internist, E.M. Tareev, devoted several paragraphs to cardiorenal interactions in his fundamental manuals “Anemia in Bright’s disease” (1929) and “Hypertension” (1948). The research on this topic was continued by Tareev’s followers: N.A. Mukhin, V.S. Moiseev, more recent successors – Zh.D. Kobalava, S.V. Moiseev, V.V. Fomin, S.V. Villevalde and others. Their contribution resulted in development of first Russian clinical guidelines on cardio and nephroprotection in CRS in 2014. In 2008 consensus of Acute Disease Quality Initiative summarized current experience on CRS. Today, research on controversial classification questions, biomarkers and other aspects of CRS continues.</p></abstract><trans-abstract xml:lang="ru"><p>В статье освещены основные этапы формирования понимания патофизиологических взаимоотношений между сердцем и почками от Древнего Египта до настоящего времени, история термина «кардиоренальный синдром» (КРС). Первые рассуждения о функции сердца и почек встречаются еще в XIII в. до н.э., на эту тему писал Гиппократ. В XIV в. Джентиле да Фолиньо предположил взаимосвязь работы сердца и почек. Ричард Брайт в XVIII в. описывает связь гипертрофии миокарда и повреждения почек. Фридрих Джастин Коллет в 1903 г. впервые употребляет термин «кардиоренальный». В нашей стране Я.Я. Стольников еще в 1880 г. проводил опыты по выявлению связи гипертрофии миокарда и ишемии почек. Е.М. Тареев уделяет наибольшее внимание проблеме взаимодействия почек и сердца в своих работах «Анемия брайтиков» (1929) и «Гипертоническая болезнь» (1948). Изучение данной проблемы активно продолжили ученики научной школы Е.М. Тареева: Н.А. Мухин, В.С. Моисеев и их последователи – Ж.Д. Кобалава, В.В. Фомин, С.В. Моисеев, С.В. Виллевальде и др., что привело к созданию первых российских рекомендаций по стратегии кардио-нефропротекции при КРС в 2014 г. Мировое сообщество впервые употребляет термин КРС в 2008 г. на конференции инициативной группы ADQI (Acute Dialysis Quality Initiative Group), в этом же году опубликованы первые клинические рекомендации по КРС. В настоящий момент проводятся исследования для уточнения ответов на спорные вопросы в отношении классификации, биомаркеров и других аспектов КРС.</p></trans-abstract><kwd-group xml:lang="en"><kwd>сardiorenal syndromes</kwd><kwd>historical aspects</kwd><kwd>acute kidney injury</kwd><kwd>chronic kidney injury</kwd><kwd>heart failure</kwd><kwd>myocardial hypertrophy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кардиоренальные синдромы</kwd><kwd>история изучения</kwd><kwd>острое почечное повреждение</kwd><kwd>хроническая болезнь почек</kwd><kwd>сердечная недостаточность</kwd><kwd>гипертрофия миокарда левого желудочка сердца</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Ronco C, House AA, Haapio M. Cardiorenal syndrome: Refining the definition of a complex symbiosis gone wrong. Intensive Care Med. 2008;34(5):957-62. 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