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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">34096</article-id><article-id pub-id-type="doi">10.26442/00403660.2020.04.000506</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Comparison of myocardial contrast stress-echocardiography and standard stress-echocardiography in detecting myocardial ischemia in patients with different severity of coronary artery stenoses</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности контрастной стресс-эхокардиографии в выявлении ишемии миокарда у больных с различным поражением коронарного русла</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1911-1256</contrib-id><name-alternatives><name xml:lang="en"><surname>Atabaeva</surname><given-names>L. S.</given-names></name><name xml:lang="ru"><surname>Атабаева</surname><given-names>Лина Салимовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>врач функциональной диагностики, аспирант отд. ультразвуковых методов исследования</p></bio><email>atabaeva_lina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3233-1862</contrib-id><name-alternatives><name xml:lang="en"><surname>Saidova</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Саидова</surname><given-names>Марина Абдулатиповна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д.м.н., проф., рук. отд. ультразвуковых методов исследования</p></bio><email>atabaeva_lina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shitov</surname><given-names>V. N.</given-names></name><name xml:lang="ru"><surname>Шитов</surname><given-names>Виктор Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>мл. науч. сотр. отд. ультразвуковых методов исследования</p></bio><email>atabaeva_lina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Staroverov</surname><given-names>I. I.</given-names></name><name xml:lang="ru"><surname>Староверов</surname><given-names>Игорь Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д.м.н., проф., рук. отд. неотложной кардиологии</p></bio><email>atabaeva_lina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Myasnikov Insitute of Clinical Cardiology, National Medical Research Center for Cardiology</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт клинической кардиологии им. А.Л. Мясникова ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-04-19" publication-format="electronic"><day>19</day><month>04</month><year>2020</year></pub-date><volume>92</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>45</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2020-05-18"><day>18</day><month>05</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/34096">https://ter-arkhiv.ru/0040-3660/article/view/34096</self-uri><abstract xml:lang="en"><p><bold>Aim. </bold>To compare diagnostic value between standard stress-echocardiography and myocardial contrast stress echocardiography in detection of myocardial ischemia in patients with different severity of coronary artery stenoses.</p> <p><bold>Materials and methods. </bold>Myocardial contrast stress-echocardiography and standard stress-echocardiography were performed in 38 patients with coronary artery stenoses over 50% by angiography. Of all lesions 39 were intermediate (50–75%) and 33 – over 75% stenoses. Fractional flow reserve (FFR) was measured in 12 coronary arteries. During myocardial contrast stress-echocardiography wall motion and myocardial perfusion was assessed.</p> <p><bold>Results. </bold>Adequate visualisation increased from 81.6% in unenhanced segments to 96.1% in contrast-enhanced segments. The sensitivity, specificity, and diagnostic accuracy of standard stress-echocardiography and myocardial contrast stress-echocardiography in intermediate (50–75%) coronary stenoses were 44%, 83%, 56% and 56%, 94% и 64% respectively compare to angiography. Taking into account the 12 arteries with evaluated FFR, these parameters increased to 52%, 93% и 65% in standard stress-echocardiography and to 68%, 100% and 75% in myocardial contrast stress-echocardiography. In coronary stenoses over 75% the sensitivity, specificity, and diagnostic accuracy of standard stress-echocardiography and myocardial contrast stress-echocardiography were 78%, 88%, 80% and 86%, 100%, 92% respectively</p> <p><bold>Conclusion. </bold>Use of contrast-enhanced stress-echorardiography significantly increased the diagnostic value of this method by improving endocardial border visualization and possibilities of myocardial perfusion assessment.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель. </bold>Сравнить диагностические возможности стандартной и миокардиальной контрастной стресс-эхокардиографии (МКСЭ) в выявлении ишемии миокарда у пациентов с различной степенью поражения коронарного русла.</p> <p><bold>Материалы и методы.</bold> Стандартная стресс-эхокардиография (стресс-ЭхоКГ) и МКСЭ проведены 38 пациентам в возрасте от 36 до 80 лет со стенозами коронарных артерий (КА) более 50% по данным коронароангиографии (КАГ). «Пограничные» (50–75%) стенозы обнаружены в 39 КА, а стенозы более 75% – в 33 КА. У 12 пациентов, в КА которых выявлены «пограничные» стенозы, проводили измерение фракционного резерва кровотока (ФРК). По данным МКСЭ, помимо оценки региональной сократимости, исследовалась также перфузия миокарда левого желудочка (ЛЖ).</p> <p><bold>Результаты. </bold>Количество сегментов ЛЖ с удовлетворительной визуализацией при введении контрастного препарата увеличилось с 81,6 до 96,1%. В отношении «пограничных» (50–75%) стенозов КА чувствительность, специфичность и точность стандартной стресс-ЭхоКГ при сравнении с КАГ составили 44, 83 и 56%, в то время как при МКСЭ эти показатели увеличивались до 56, 94 и 64% соответственно. С учетом ФРК, измеренного в 12 КА, чувствительность, специфичность и точность стандартной стресс-ЭхоКГ повышались до 52, 93 и 65%, а МКСЭ – до 68, 100 и 75%. Для стенозов более 75% чувствительность стандартной стресс-ЭхоКГ составила 78%, специфичность – 88%, точность – 80%, а при МКСЭ – 86, 100 и 92% соответственно.</p> <p><bold>Заключение. </bold>Использование ультразвуковых контрастных препаратов при стресс-ЭхоКГ значительно увеличивает информативность метода у больных с различной степенью поражения КА за счет улучшения визуализации границ эндокарда ЛЖ и дополнительной возможности оценки перфузии миокарда.</p></trans-abstract><kwd-group xml:lang="en"><kwd>myocardial contrast stress-echocardiography</kwd><kwd>ultrasound contrast agents</kwd><kwd>myocardial ischemia</kwd><kwd>myocardial perfusion</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>миокардиальная контрастная стресс-эхокардиография</kwd><kwd>ультразвуковые контрастные препараты</kwd><kwd>ишемия миокарда</kwd><kwd>перфузия миокарда</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Boytsov SА, Zayratiants ОV, et al. Comparison of coronary heart disease mortality in men and woman age 50 years and older in Russia and USA. Russ J Cardiol. 2017;6(146):100-7.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Popma JJ, Chan S. Cardiac Catheterization and Percutaneous Coronary Intervention. In: Cannon CP, O’Gara PT (eds). Critical Pathways in Cardiology. Philadephia (PA): Lippincott Williams &amp; Wilkins. 2001:142-7.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Zamorano JL, Achenbach S, et al. The Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34:2949-3003.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Porter TR, et al. Guidelines for the Cardiac Sonographer in the Performance of Contrast Echocardiography: A Focused Update from the American Society of Echocardiography. J Am Soc Echocardiogr. 2014;27(8):797-810.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Porter TR, Mulvagh ShL, et al. Clinical Applications of Ultrasonic Enhancing Agents in Echocardiography: 2018 American Society of Echocardiography Guidelines Update. J Am Soc Echocardiogr. 2018;31(3): 241-74.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Senior R, Moreo A, Gaibazzi N, et al. Comparison of sulfur hexafluoride microbubble (SonoVue)-enhanced myocardial echocardiography to gated single photon emission computerized tomography for the detection of significant coronary artery disease: a large European multicenter study. J Am Coll Cardiol. 2013;62:1353-61.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Picano E. Stress Echocardiography. Sixth Edition. CNR Pisa Ist. Fisiologia Clinica. Italy, 2015.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Verma B, Singh A. Comparison of Contrast Enhanced Low-Dose Dobutamine Stress Echocardiography with 99mTc-Sestamibi Single-Photon Emission Computed Tomography in Assessment of Myocardial Viability. Open Access Maced J Med Sci. 2019;7(8):1287-92.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Porter TR, Smith LM, Wu J, et al. Patient outcome following 2 different stress imaging approaches. J Am Coll Cardiol. 2013;61:2246-455.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Shah BN, Balaji G, Alhajiri A, et al. Incremental diagnostic and prognostic value of contemporary stress echocardiography in a chest pain unit: mortality and morbidity outcomes from a real-world setting. Circ Cardiovasc Imaging. 2013;6:202-9.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Thomas D, Xie F, Smith LM, et al. Prospective randomized comparison of conventional stress echocardiography and real time perfusion stress echocardiography in detecting significant coronary artery disease. J Am Soc Echocardiogr. 2012;25:1207-14.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Plana JC, Mikati IA, Dokainish H, et al. A randomized cross-over study for evaluation of the effect of image optimization with contrast on the diagnostic accuracy of dobutamine echocardiography in coronary artery disease: the OPTIMIZE trial. JACC Cardiovasc Imaging. 2008;1: 145-52.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Arnold JR, Karamitsos TD, Pegg TJ, et al. Adenosine stress myocardial contrast echocardiography for the detection of coronary artery disease: a comparison with coronary angiography and cardiac magnetic resonance. JACC Cardiovasc Imaging. 2010;3:934-43.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Porter TR, Adolphson M, High RR, et al. Rapid detection of coronary artery stenoses with real-time perfusion echocardiography during regadenoson stress. Circ Cardiovasc Imaging. 2011;4:628-35.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Gaibazzi N, Reverberi C, Lorenzoni V, et al. Prognostic value of high-dose dipyridamole stress myocardial contrast perfusion echocardiography. Circulation. 2012;126:1217-24.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Miszalski-Jamka T, Kuntz-Hehner S, Schmidt H, et al. Myocardial contrast echocardiography enhances long-term prognostic value of supine bicycle stress two dimensional echocardiography. J Am Soc Echocardiogr. 2009;22:1220-7.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Gaibazzi N, Porter T, Lorenzoni V, et al. Effect of Coronary Revascularization on the Prognostic Value of Stress Myocardial Contrast Wall Motion and Perfusion Imaging. J Am Heart Assoc. 2017;6(6). pii: e006202. doi: 10.1161/JAHA.117.006202</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Nihoyannopoulos P, Kisslo J. Echocardiography Second Edition. Springer International Publishing AG, part of Springer Nature 2018.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Toth G, Hamilos M, Pyxaras S, et al. Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenoses. Eur Heart J. 2014;35;2831-8.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Tonino PAL, Fearon WF, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME Study: Fractional Flow Reserve versus angiography in multivessel evaluation. J Am Coll Cardiol. 2010;55(25):2816-21.</mixed-citation></ref></ref-list></back></article>
