Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya34085710.26442/00403660.2023.09.202368Original articlesОригинальные статьиResearch ArticleEffect of dapagliflozin on the dynamics of magnetic resonance imaging in patients with heart failure and atrial fibrillationВлияние дапаглифлозина на динамику показателей магнитно-резонансной томографии у пациентов с сердечной недостаточностью и фибрилляцией предсердийhttps://orcid.org/0000-0002-3757-1160SaipudinovaKarina M.СайпудиноваКарина Магомедовна
Russian Federation

doctor-graduate student dept. myocardial diseases and heart failure

врач-аспирант отд. заболеваний миокарда и сердечной недостаточности

saiputdinova93@mail.ruhttps://orcid.org/0000-0003-4318-0315UskachTatiana M.УскачТатьяна Марковна
Russian Federation

Doctor of Medical Sciences, Ved. Researcher Dept. myocardial diseases and heart failure, professor of the Department of Cardiology

доктор медицинских наук, вед. научный сотрудник отд. заболеваний миокарда и сердечной недостаточности, профессор кафедры кардиологии

tuskach@mail.ruhttps://orcid.org/0000-0002-0370-5204ShariyaMerab А.ШарияМераб Арчильевич
Russian Federation

Doctor of Medical Sciences, Ved. Researcher at the Department of Tomography, Professor at the Department of Radiation Diagnostics and Radiation Therapy

доктор медицинских наук, вед. научный сотрудник отделения томографии, профессор кафедры лучевой диагностики и лучевой терапии

mershar@yandex.ruhttps://orcid.org/0000-0002-0402-3977UstyuzhaninDmitry V.УстюжанинДмитрий Владимирович
Russian Federation

Candidate of Medical Sciences, Senior Researcher, Tomography Department

кандидат медицинских наук, старший научный сотрудник отделения томографии

d-ust@yandex.ruhttps://orcid.org/0000-0003-0580-393XDobrovolskayaSvetlana V.ДобровольскаяСветлана Валерьевна
Russian Federation

junior researcher dept. ultrasound research methods

младший научный сотрудник отд. ультразвуковых методов исследования

S_dobrovolskaya@mail.ruhttps://orcid.org/0000-0001-9234-6129TereshchenkoSergey N.ТерещенкоСергей Николаевич
Russian Federation

Doctor of Medical Sciences, Professor, Head of Department. myocardial diseases and heart failure

доктор медицинских наук, профессор, руководитель отд. заболеваний миокарда и сердечной недостаточности

tereschenko@yandex.ruChazov National Medical Research Center of CardiologyФГБУ «Национальный медицинский исследовательский центр кардиологии имени акад. Е.И. Чазова» Минздрава РоссииRussian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииSechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)0311202395977678120042023Copyright ©; 2023, Consilium MedicumCopyright ©; 2023, ООО "Консилиум Медикум"2023Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/340857

Aim. To determine the effect of dapagliflozin therapy on myocardial remodeling and fibrosis according to magnetic resonance imaging (MRI) with contrast in patients with chronic heart failure (CHF) and atrial fibrillation (AF).

Materials and methods. In the group of 22 patients with a combination of CHF and AF we analyzed the dynamics of remodeling parameters and assessed myocardial fibrosis during 6-month therapy with dapagliflozin according to cardiac MRI with contrast.

Results. After 6 months of dapagliflozin therapy there was a statistically significant increase in LVEF (27 [23-32]-32 [26.5-36.5] p-0.04) and a tendency to decrease volume and linear dimensions of LV, LP. There was no progression of myocardial fibrosis according to the results of cardiac MRI with contrast in patients with HFrFV and AF.

Conclusions. Dapagliflozin therapy in patients with HFrEF and AF led to favorable myocardial remodeling changes.

Цель. Определить влияние терапии дапаглифлозином на показатели ремоделирования и фиброза миокарда по данным магнитно-резонансной томографии (МРТ) сердца с контрастированием у пациентов с хронической сердечной недостаточностью (ХСН) и фибрилляцией предсердий (ФП).

Материалы и методы: В группе из 22-х пациентов с сочетанием ХСН и ФП проанализирована динамика параметров ремоделирования и проведена оценка фиброза миокарда на фоне 6-месячной терапии дапаглифлозином по данным МРТ сердца с контрастированием

Результаты: Через 6 месяцев терапии дапаглифлозином наблюдается статистический значимый прирост ФВЛЖ (27 [23-32]- 32 [26,5-36,5] р-0,04) и тенденция к снижению объемных и линейных размеров ЛЖ, ЛП. В течение наблюдения не произошло прогрессирования фиброза миокарда по результатам МРТ сердца с контрастированием у пациентов с ХСНнФВ и ФП.

Заключение: Применение дапаглифлозина у пациентов ХСНнФВ и ФП сопровождалось положительной динамикой обратного ремоделирования миокарда.

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