Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya3375310.26442/00403660.2019.12.000455Editorial articleПередовая статьяReview ArticleDiseases of biliary tract in the context of association with oncological diseases of the digestive systemБолезни билиарного тракта в контексте ассоциации с онкологическими заболеваниями пищеварительной системыOsadchukM AОсадчукМ АSvistunovA AСвистуновА АMironovaE DМироноваЕ ДVasil’evaI NВасильеваИ НKireevaN VКирееваН ВSechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)151220199112VOL 91, NO12 (2019)ТОМ 91, №12 (2019)9810416042020Copyright ©; 2019, Consilium MedicumCopyright ©; 2019, ООО "Консилиум Медикум"2019Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/33753

Cancers of the gastrointestinal tract are widespread among the population and cause significant damage to the health care system. In order to improve the strategy of preventive measures and the detection of oncological diseases at the early stages, it is necessary to provide timely impact on possible risk factors contributing to the onset and progression of malignant neoplasms. This review demonstrates the association between the pathology of the biliary tract and oncological diseases of the digestive system, discusses the possible mechanisms of the influence of cholelithiasis and cholecystectomy on the development of malignant neoplasms of various parts of the gastrointestinal tract.

Болезни билиарного тракта в контексте ассоциации с онкологическими заболеваниями пищеварительной системы Онкологические заболевания желудочно - кишечного тракта (ЖКТ) наносят наиболее ощутимый ущерб системе здравоохранения. Для улучшения стратегии профилактических мероприятий и выявления онкологических заболеваний на ранних стадиях необходимо своевременно прогнозировать влияние возможных факторов риска, способствующих возникновению и прогрессированию злокачественных новообразований. В данном обзоре продемонстрирована ассоциация между патологией билиарного тракта и онкологическими заболеваниями пищеварительной системы, рассмотрены возможные механизмы влияния желчнокаменной болезни и холецистэктомии на развитие злокачественных новообразований различных отделов ЖКТ.

oncologycancergastrointestinal tractdigestive systemgallstone diseasebile acidsbiliary tractонкологияракжелудочно кишечный трактпищеварительная системажелчнокаменная болезньжелчные кислотыбилиарный трактSiegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30. doi: 10.3322/caac.21166Каприн А.Д., Старинский В.В., Петрова Г.В., ред. Злокачественные новообразования в России в 2017 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена Филиал ФГБУ «НМИЦ Радиологии» Минздрава России, 2018.Jemal A, Bray F, Center M.M, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90. doi: 10.3322/caac.20107Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359-386. doi: 10.1002/ijc.29210Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet. 2006;368(9531):230-9. doi: 10.1016/S0140-6736(06)69044-2Everhart J.E, Ruhl C.E. Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Gastroenterology. 2009;136(2):376-86. doi: 10.1053/j.gastro.2008.12.015Farthing M, Roberts.SE, Samuel D.G, et al. Survey of digestive health across Europe: Final report. Part 1: The burden of gastrointestinal diseases and the organisation and delivery of gastroenterology services across Europe. United European Gastroenterol J. 2014;2(6):539-43. doi: 10.1177/2050640614554154Rodriguez S, Gaunt T.R, Guo Y, et al. Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular genecentric 50K SNP array. Eur J Hum Genet. 2016;24(1):106-12. doi: 10.1038/ejhg.2015.63Fukuma H, Morshed S.A, Watanabe S, et al. Increased expression of cytokines in liver and serum in patients with extrahepatic diseases. J Gastroenterol. 1996;31(4):538-45.Chiba T, Marusawa H, Ushijima T. Inflammation - associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology. 2012;143(3):550-63. doi: 10.1053/j.gastro.2012.07.009Grivennikov S.I, Greten F.R, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883-99. doi: 10.1016/j.cell.2010.01.025Abbas T, Keaton M.A, Dutta A. Genomic instability in cancer. Cold Spring Harb Perspect Biol. 2013;5(3):a012914. doi: 10.1101/cshperspect.a012914Allavena P, Sica A, Solinas G, Porta C, Mantovani A. The inflammatory micro - environment in tumor progression: the role of tumor - associated macrophages. Crit Rev Oncol Hematol. 2008;66(1):1-9. doi: 10.1016/j.critrevonc.2007.07.004Zang J, Yuan Y, Zhang C, Gao J. Elective laparoscopic cholecystectomy without intraoperative cholangiography: role of preoperative magnetic resonance cholangiopancreatography - a retrospective cohort study. BMC Surg. 2016;16(1):45. doi: 10.1186/s12893-016-0159-9Holzheimer R.G, Mannick J.A, eds. Surgical Treatment: Evidence-Based and Problem-Oriented. Munich: Zuckschwerdt; 2001. Accessed July 03, 2019. http://www.ncbi.nlm.nih.gov/books/NBK6880/Mahid S.S, Jafri N.S, Brangers B.C, Minor K.S, Hornung C.A, Galandiuk S. Meta - analysis of cholecystectomy in symptomatic patients with positive hepatobiliary iminodiacetic acid scan results without gallstones. Arch Surg. 2009;144(2):180-7. doi: 10.1001/archsurg.2008.543Sonne D.P, Hare K.J, Martens P, et al. Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients. Am J Physiol Gastrointest Liver Physiol. 2013;304(4):G413-419. doi: 10.1152/ajpgi.00435.2012Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72:137-74. doi: 10.1146/ annurev.biochem.72.121801.161712Hofmann A.F. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med. 1999;159(22):2647-58.Chiang J.Y.L. Bile acids: regulation of synthesis. J Lipid Res. 2009;50(10):1955-66. doi: 10.1194/jlr.R900010-JLR200Russell D.W, Setchell K.D. Bile acid biosynthesis. Biochemistry. 1992;31(20):4737-49.Ridlon J.M, Kang D-J, Hylemon P.B. Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2006;47(2):241-59. doi: 10.1194/jlr.R500013-JLR200Chiang J.Y.L. Bile Acid Metabolism and Signaling. Compr Physiol. 2013;3(3):1191-212. doi: 10.1002/cphy.c120023Di Ciaula A, Garruti G, Lunardi Baccetto R, et al. Bile Acid Physiology. Ann Hepatol. 2017;16:S4-S14. doi: 10.5604/01.3001.0010.5493Staley C, Weingarden A.R, Khoruts A, Sadowsky M.J. Interaction of Gut Microbiota with Bile Acid Metabolism and its Influence on Disease States. Appl Microbiol Biotechnol. 2017;101(1):47-64. doi: 10.1007/s00253-016-8006-6Chen Y-K, Yeh J-H, Lin C-L, et al. Cancer risk in patients with cholelithiasis and after cholecystectomy: a nationwide cohort study. J Gastroenterol. 2014;49(5):923-31. doi: 10.1007/s00535-013-0846-6Bernstein C, Holubec H, Bhattacharyya A.K, et al. Carcinogenicity of deoxycholate, a secondary bile acid. Arch Toxicol. 2011;85(8):863-71. doi: 10.1007/s00204-011-0648-7Reddy B.S, Wynder E.L. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer. 1977;39(6):2533-9.Huo X, Juergens S, Zhang X, et al. Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett’s epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011;301(2):G278-286. doi: 10.1152/ajpgi.00092.2011Wang X, Sun L, Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c- Myc expression. Cancer Med. 2017;6(4):788-97. doi: 10.1002/cam4.999Nagathihalli N.S, Beesetty Y, Lee W, et al. Novel mechanistic in - sights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids. Cancer Res. 2014;74(7):2062-72. doi: 10.1158/0008-5472.CAN-13-2329Quante M, Bhagat G, Abrams J.A, et al. Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett - like metaplasia. Cancer Cell. 2012;21(1):36-51. doi: 10.1016/j.ccr.2011.12.004Fitzgerald R.C, Abdalla S, Onwuegbusi B.A, et al. Inflammatory gradient in Barrett’s oesophagus: implications for disease complications. Gut. 2002;51(3):316-22.Attili A.F, Angelico M, Cantafora A, Alvaro D, Capocaccia L. Bile acid - induced liver toxicity: relation to the hydrophobic - hydrophilic balance of bile acids. Med Hypotheses. 1986;19(1):57-69.Tucker O.N, Dannenberg A.J, Yang E.K, Fahey T.J. Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. Carcinogenesis. 2004;25(3):419-23. doi: 10.1093/carcin/bgh010Koga S, Kaibara N, Takeda R. Effect of bile acids on 1,2-dimethylhydrazine - induced colon cancer in rats. Cancer. 1982;50(3):543-7.Zuccato E, Venturi M, Di Leo G, et al. Role of bile acids and metabolic activity of colonic bacteria in increased risk of colon cancer after cholecystectomy. Dig Dis Sci. 1993;38(3):514-9.Perez M-J, Briz O. Bile - acid - induced cell injury and protection. World J Gastroenterol. 2009;15(14):1677-89. doi: 10.3748/wjg.15.1677Lagergren J, Mattsson F. Cholecystectomy as a risk factor for oesophageal adenocarcinoma. Br J Surg. 2011;98(8):1133-7. doi: 10.1002/bjs.7504Freedman J, Ye W, Näslund E, Lagergren J. Association between cholecystectomy and adenocarcinoma of the esophagus. Gastroenterology. 2001;121(3):548-53.Ge Z, Zhao C, Wang Y, Qian J. Cholecystectomy and the risk of esophageal and gastric cancer. Saudi Med J. 2012;33(10):1073-9.Огнерубов Н.А. Желчнокаменная болезнь после хирургического лечения рака желудка: оправдана ли профилактическая холецистэктомия? Вестник ТГУ. 2017;22(1):148-54. doi: 10.20310/1810-0198-2017-22-1-148-154Inoue K, Fuchigami A, Higashide S, et al. Gallbladder sludge and stone formation in relation to contractile function after gastrectomy. A prospective study. Ann Surg. 1992;215(1):19-26.Hauters P.P, de Neve de Roden A, Pourbaix A, Aupaix F, Coumans P, Therasse G. Cholelithiasis: a serious complication after total gastrectomy. Br J Surg. 1988;75:899-900.Kobayashi T, Hisanaga M, Kanehiro H, Yamada Y, Ko S, Nakajima Y. Analysis of risks factors for the development of gallstones after gastrectomy. Br J Surg.2005;92:1399-403. doi: 10.1002/bjs.5117Ichimiya H, Kono S, Ikeda M, Tokudome S, Nakayama F, Kuratsune M. Cancer mortality among patients undergoing cholecystectomy for benign biliary diseases. Jpn J Cancer Res. 1986;77(6):579-83.Freedman J, Lagergren J, Bergström R, Näslund E, Nyrén O. Cholecystectomy, peptic ulcer disease and the risk of adenocarcinoma of the oesophagus and gastric cardia. Br J Surg. 2000;87(8):1087-93. doi: 10.1046/j.1365-2168.2000.01459.xKalima T, Sjöberg J. Bile reflux after cholecystectomy. Scand J Gastroenterol Suppl. 1981;67:153-6.Kang S.H, Kim Y.H, Roh Y.H, et al. Gallstone, cholecystectomy and risk of gastric cancer. Ann Hepatobiliary Pancreat Surg. 2017;21(3):131-7. doi: 10.14701/ahbps.2017.21.3.131Nogueira L, Freedman N.D, Engels E.A, Warren J.L, Castro F, Koshiol J. Gallstones, cholecystectomy, and risk of digestive system cancers. Am J Epidemiol. 2014;179(6):731-9. doi: 10.1093/aje/kwt322Hardt P.D, Bretz L, Krauss A, et al. Pathological pancreatic exocrine function and duct morphology in patients with cholelithiasis. Dig Dis Sci. 2001;46(3):536-9.Gong Y, Li S, Tang Y, et al. Cholelithiasis and risk of pancreatic cancer: systematic review and meta - analysis of 21 observational studies. Cancer Causes Control. 2014;25(11):1543-51. doi: 10.1007/s10552-014-0458-3Hyvärinen H, Partanen S. Association of cholecystectomy with abdominal cancers. Hepatogastroenterology. 1987;34(6):280-4.Smith J.P, Solomon T.E, Bagheri S, Kramer S. Cholecystokinin stimulates growth of human pancreatic adenocarcinoma SW-1990. Dig Dis Sci. 1990;35(11):1377-84.Palmer W.C, Patel T. Are common factors involved in the pathogenesis of primary liver cancers? A meta - analysis of risk factors for intrahepatic cholangiocarcinoma. J Hepatol. 2012;57(1):69-76. doi: 10.1016/j. jhep.2012.02.022Ioannou G.N. Cholelithiasis, cholecystectomy, and liver disease. Am J Gastroenterol. 2010;105(6):1364-73. doi: 10.1038/ajg.2009.737Guo L, Mao J, Li Y, et al. Cholelithiasis, cholecystectomy and risk of hepatocellular carcinoma: a meta - analysis. J Cancer Res Ther. 2014;10(4):834-8. doi: 10.4103/0973-1482.135992Wang Y, Xie L-F, Lin J. Gallstones and cholecystectomy in relation to risk of liver cancer. Eur J Cancer Prev. 2019;28(2):61-7. doi: 10.1097/CEJ.0000000000000421Liu Y, He Y, Li T, et al. Risk of primary liver cancer associated with gallstones and cholecystectomy: a meta - analysis. PLoS ONE. 2014;9(10):e109733. doi: 10.1371/journal.pone.0109733Xiong J, Wang Y, Huang H, et al. Systematic review and meta - analysis: cholecystectomy and the risk of cholangiocarcinoma. Oncotarget. 2017;8(35):59648-57. doi: 10.18632/oncotarget.19570Medavaram S, Zhang Y. Emerging therapies in advanced hepatocellular carcinoma. Exp Hematol Oncol. 2018;7. doi: 10.1186/s40164-018-0109-6Siegel R.L, Miller K.D, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7-30. doi: 10.3322/caac.21442Dimitroulis D, Damaskos C, Valsami S, et al. From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world. World J Gastroenterol. 2017;23(29):5282-94. doi: 10.3748/wjg.v23.i29.5282El-Serag H.B. Hepatocellular carcinoma. N Engl J Med. 2011;365(12):1118-27. doi: 10.1056/NEJMra1001683Johansen C, Chow W.H, Jørgensen T, Mellemkjaer L, Engholm G, Olsen J.H. Risk of colorectal cancer and other cancers in patients with gall stones. Gut. 1996;39(3):439-43. doi: 10.1136/gut.39.3.439Tavani A, Rosato V, Di Palma F, et al. History of cholelithiasis and cancer risk in a network of case - control studies. Ann Oncol. 2012;23(8):2173-8. doi: 10.1093/annonc/mdr581Deschner E.E, Cohen B.I, Raicht R.F. Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation. Digestion. 1981;21(6):290-6. doi: 10.1159/000198579Cohen B.I, Raicht R.F, Deschner E.E, Takahashi M, Sarwal A.N, Fazzini E. Effect of cholic acid feeding on N-methyl-N-nitrosourea - induced colon tumors and cell kinetics in rats. J Natl Cancer Inst. 1980;64(3):573-8.Pomare E.W, Heaton K.W. The effect of cholecystectomy on bile salt metabolism. Gut. 1973;14(10):753-62.El Zoghbi M, Cummings L.C. New era of colorectal cancer screening. World J Gastrointest Endosc. 2016;8(5):252-8. doi: 10.4253/wjge.v8.i5.252Berkhout M, Roelofs H.M.J, Friederich P, et al. Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: a pilot study. Transl Res. 2007;150(3):147-9. doi:10.1016/j.trsl.2007.03.009Zhao M-F, Huang P, Ge C-L, Sun T, Ma Z-G, Ye F-F. Conjugated bile acids in gallbladder bile and serum as potential biomarkers for cholesterol polyps and adenomatous polyps. Int J Biol Markers. 2016;31(1):e73-79. doi: 10.5301/jbm.5000173Cheng K, Metry M, Felton J, Shang A.C, Drachenberg C.B, Xu S, Zhan M, Schumacher J, Guo G.L, Polli J.E, Raufman J.P. Diminished gallbladder filling, increased fecal bile acids, and promotion of colon epithelial cell proliferation and neoplasia in fibroblast growth factor 15-deficient mice. Oncotarget. 2018;9(39):25572-85.Flynn C, Montrose D.C, Swank D.L, Nakanishi M, Ilsley J.N, Rosenberg D.W. Deoxycholic acid promotes the growth of colonic aberrant crypt foci. Mol Carcinog. 2007;46(1):60-70. doi: 10.1002/mc.20253Raufman J.P, Dawson P.A, Rao A, Drachenberg C.B, Heath J, Shang A.C, Hu S, Zhan M, Polli J.E, Cheng K. Slc10a2-null mice uncover colon cancer - promoting actions of endogenous fecal bile acids. Carcinogenesis. 2015;36(10):1193-200. doi: 10.1093/carcin/bgv107Wang W, Wang J, Li J, et al. Cholecystectomy Damages Aging-Associated Intestinal Microbiota Construction. Front Microbiol. 2018;9. doi: 10.3389/fmicb.2018.01402Galitskiy M, Khomeriki S, Nikiforov P. Expression of proliferation and apoptosis markers in neoplasms of colon mucosa after cholecystectomy. Eksp Klin Gastroenterol. 2009;(5):28-32.Zhang Y, Liu H, Li L, et al. Cholecystectomy can increase the risk of colorectal cancer: A meta - analysis of 10 cohort studies. PLoS ONE. 2017;12(8):e0181852. doi: 10.1371/journal.pone.0181852Giovannucci E, Colditz G.A, Stampfer M.J. A meta - analysis of cholecystectomy and risk of colorectal cancer. Gastroenterology. 1993;105(1):130-41.Xu Y-K, Zhang F-L, Feng T, Li J, Wang Y-H. [Meta - analysis on the correlation of cholecystectomy or cholecystolithiasis to risk of colorectal cancer in Chinese population]. Ai Zheng. 2009;28(7):749-55.Chiong C, Cox M.R, Eslick G.D. Gallstone disease is associated with rectal cancer: a meta - analysis. Scand J Gastroenterol. 2012;47(5):553-64. doi: 10.3109/00365521.2012.660538Chiong C, Cox M.R, Eslick G.D. Gallstones are associated with colonic adenoma: a meta - analysis. World J Surg. 2012;36(9):2202-9. doi: 10.1007/s00268-012-1646-5